Results 351 to 360 of about 266,614 (380)

Antisense Anticancer Oligonucleotide Therapeutics

Current Cancer Drug Targets, 2001
Recent progress made in molecular biology, biotechnology, and genetics, especially in identifying, cloning, sequencing and characterization of normal and pathogenic genes, has led to the development of genetic therapy. Major efforts in the field can be summarized in two general approaches: gene therapy and antisense therapy. The second is to deliver to
Gautam Prasad, Hui Wang, Ruiwen Zhang, John K. Buolamwini   +3 more
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Specificity of antisense oligonucleotides

Perspectives in Drug Discovery and Design, 1996
Antisense oligodeoxynucleotides that are sufficiently long to specify unique species of mRNA may direct ribonuclease H (RNase H) to cleave nontargeted mRNAs at sites of partial complementarity, both in cell-free systems and in living cells. Specificity of antisense action against selected gene expression may be achieved by increasing the stringency of ...
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Conjugated Antisense Oligonucleotides

Nucleosides and Nucleotides, 1997
Abstract We have employed chemical modification strategies to improve cellular ahsorption of oligonucleotides. These include the conjugation of various pendant moieties to the oligonucleotide to affect its overall physical properties such as hydrophobicity, charge, and amphipathicity as well as pendants that may mediate absorption by binding to certain
Isabelle Barber-Peoc'h, Thomas P. Condon, P. Dan Cook, Stanley T. Crooke, Laura K. Andrade, Kathleen L. Tivel, C. Frank Bennett, Muthiah Manoharan, Mark J. Graham, Shefali Shah, Gopal B. Inamati, Venkatraman Mohan   +11 more
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Antisense oligonucleotide strategies in physiology

Molecular and Cellular Endocrinology, 1994
Antisense oligonucleotides can inhibit gene expression in living cells by binding to complementary sequences of DNA, RNA or mRNA. The mechanisms include inhibition of RNA synthesis, RNA splicing, mRNA export, binding of initiation factors, assembly of ribosome subunits and of sliding of the ribosome along the mRNA coding sequence.
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Antisense Oligonucleotides as Research Tools

2003
The use of antisense oligonucleotides as both research tools and therapeutic molecules has emerged as a powerful alternative to small molecule inhibitors. Antisense oligonucleotides are short pieces of chemically modified DNA designed to hybridize to specific mRNA sequences present in the target gene.
Nicholas M. Dean, Scott Cooper, Jennifer K. Taylor   +2 more
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An oral antisense oligonucleotide for PCSK9 inhibition

Science Translational Medicine, 2021
Peter Gennemark, Katrin Walter, N. Clemmensen, D. Rekić, C. Nilsson, Jane Knöchel, M. Hölttä, Linda Wernevik, B. Rosengren, D. Kakol-Palm, Yanfeng Wang, R. Yu, R. Geary, Stan J. Riney, B. Monia, Rikard Isaksson, R. Jansson-Löfmark, Cristina S. J. Rocha, D. Lindén, E. Hurt-Camejo, R. Crooke, L. Tillman, T. Rydén-Bergsten, B. Carlsson, U. Andersson, M. Elebring, A. Tivesten, N. Davies   +27 more
semanticscholar   +1 more source

Identification of GalNAc-Conjugated Antisense Oligonucleotide Metabolites Using an Untargeted and Generic Approach Based on High Resolution Mass Spectrometry.

Analytical Chemistry, 2017
Antisense oligonucleotides linked by phosphorothioates are an important class of therapeutics under investigation in various pharmaceutical companies. Antisense oligonucleotides may be coupled to high-affinity ligands (triantennary N-acetyl galactosamine
C. Husser, A. Brink, M. Zell, M. Müller, Erich Koller, S. Schadt   +5 more
semanticscholar   +1 more source

The concept and application of antisense oligonucleotides

Diseases of the Colon & Rectum, 2001
Since the identification of the double-stranded DNA helix by Watson and Crick in 1953, the knowledge of nucleotide structure and function has been an important potential tool in the study and therapy of disease. There is recent clinical evidence that antisense oligonucleotides may be important therapeutic compounds in the clinical therapy of a range of
Stanley T. Crooke, Bruce R. Yacyshyn
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Antisense Oligonucleotides: The State of the Art

Current Medicinal Chemistry, 2005
The use of antisense oligonucleotides as therapeutic agents has generated considerable enthusiasm in the research and medical community. Antisense oligonucleotides as therapeutic agents were proposed as far back as in the 1970s when the antisense strategy was initially developed.
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Antisense and/or Immunostimulatory Oligonucleotide Therapeutics

Current Cancer Drug Targets, 2001
Antisense technology, which is based on a simple and rational principle of Watson-Crick complementary base pairing of a short oligonucleotide with the targeted mRNA to downregulate the disease-causing gene product, has progressed tremendously in the last two decades.
Sudhir Agrawal, E R Kandimalla
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