Results 361 to 370 of about 266,614 (380)
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Innovations in the Use of Antisense Oligonucleotides
Annals of the New York Academy of Sciences, 1990The use of antisense oligonucleotides for controlling genetic expression has recently received widespread attention, especially as a new class of potential chemotherapeutic agents. This coupled with the urgency of developing new effective therapies for acquired immunodeficiency syndrome (AIDS) has led to various antisense studies dealing with human ...
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Antisense oligonucleotide pharmacokinetics and metabolism
Expert Opinion on Drug Metabolism & Toxicology, 2009The use of oligonucleotides as therapeutic agents has elicited a great deal of interest. Basic understanding and evaluation of the pharmacokinetic properties of oligonucleotides is foundational to their appropriate design and application.To review the primary pharmacokinetic properties that drive successful use and delivery of oligonucleotides.The ...
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Knocking Down Long Noncoding RNAs Using Antisense Oligonucleotide Gapmers.
Methods in molecular biology, 2020R. Maruyama, T. Yokota
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antisense oligonucleotides (AS-ODNs)
2009Class of new therapeutics planned for the treatment of viral infections, autoimmune disease, endocrine disease and cancers; AS-ODNs are small synthetic molecules of single-stranded DNA that suppress gene expression by binding to RNA templates in a sequence-specific manner, thus suppressing gene expression, mRNA translation and therefore the production ...
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Antisense Oligonucleotides as Antiviral Agentsa
Annals of the New York Academy of Sciences, 1992Alan D. B. Malcolm, Judy M. Coulson
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An Antisense Oligonucleotide Primer
Antisense and Nucleic Acid Drug Development, 1999openaire +3 more sources
Antisense oligonucleotide therapeutics
Expert Opinion on Investigational Drugs, 1999openaire +3 more sources