Results 381 to 390 of about 263,255 (408)

Antisense Oligonucleotides as Research Tools

2003
The use of antisense oligonucleotides as both research tools and therapeutic molecules has emerged as a powerful alternative to small molecule inhibitors. Antisense oligonucleotides are short pieces of chemically modified DNA designed to hybridize to specific mRNA sequences present in the target gene.
Nicholas M. Dean, Scott Cooper, Jennifer K. Taylor   +2 more
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Antisense oligonucleotide strategies in physiology

Molecular and Cellular Endocrinology, 1994
Antisense oligonucleotides can inhibit gene expression in living cells by binding to complementary sequences of DNA, RNA or mRNA. The mechanisms include inhibition of RNA synthesis, RNA splicing, mRNA export, binding of initiation factors, assembly of ribosome subunits and of sliding of the ribosome along the mRNA coding sequence.
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An oral antisense oligonucleotide for PCSK9 inhibition

Science Translational Medicine, 2021
Peter Gennemark, Katrin Walter, N. Clemmensen, D. Rekić, C. Nilsson, Jane Knöchel, M. Hölttä, Linda Wernevik, B. Rosengren, D. Kakol-Palm, Yanfeng Wang, R. Yu, R. Geary, Stan J. Riney, B. Monia, Rikard Isaksson, R. Jansson-Löfmark, Cristina S. J. Rocha, D. Lindén, E. Hurt-Camejo, R. Crooke, L. Tillman, T. Rydén-Bergsten, B. Carlsson, U. Andersson, M. Elebring, A. Tivesten, N. Davies   +27 more
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Antisense Oligonucleotides: The State of the Art

Current Medicinal Chemistry, 2005
The use of antisense oligonucleotides as therapeutic agents has generated considerable enthusiasm in the research and medical community. Antisense oligonucleotides as therapeutic agents were proposed as far back as in the 1970s when the antisense strategy was initially developed.
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Antisense and/or Immunostimulatory Oligonucleotide Therapeutics

Current Cancer Drug Targets, 2001
Antisense technology, which is based on a simple and rational principle of Watson-Crick complementary base pairing of a short oligonucleotide with the targeted mRNA to downregulate the disease-causing gene product, has progressed tremendously in the last two decades.
Sudhir Agrawal, E R Kandimalla
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Conjugated Antisense Oligonucleotides

Nucleosides and Nucleotides, 1997
Abstract We have employed chemical modification strategies to improve cellular ahsorption of oligonucleotides. These include the conjugation of various pendant moieties to the oligonucleotide to affect its overall physical properties such as hydrophobicity, charge, and amphipathicity as well as pendants that may mediate absorption by binding to certain
Isabelle Barber-Peoc'h, Thomas P. Condon, P. Dan Cook, Stanley T. Crooke, Laura K. Andrade, Kathleen L. Tivel, C. Frank Bennett, Muthiah Manoharan, Mark J. Graham, Shefali Shah, Gopal B. Inamati, Venkatraman Mohan   +11 more
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The concept and application of antisense oligonucleotides

Diseases of the Colon & Rectum, 2001
Since the identification of the double-stranded DNA helix by Watson and Crick in 1953, the knowledge of nucleotide structure and function has been an important potential tool in the study and therapy of disease. There is recent clinical evidence that antisense oligonucleotides may be important therapeutic compounds in the clinical therapy of a range of
Stanley T. Crooke, Bruce R. Yacyshyn
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Innovations in the Use of Antisense Oligonucleotides

Annals of the New York Academy of Sciences, 1990
The use of antisense oligonucleotides for controlling genetic expression has recently received widespread attention, especially as a new class of potential chemotherapeutic agents. This coupled with the urgency of developing new effective therapies for acquired immunodeficiency syndrome (AIDS) has led to various antisense studies dealing with human ...
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Antisense oligonucleotide pharmacokinetics and metabolism

Expert Opinion on Drug Metabolism & Toxicology, 2009
The use of oligonucleotides as therapeutic agents has elicited a great deal of interest. Basic understanding and evaluation of the pharmacokinetic properties of oligonucleotides is foundational to their appropriate design and application.To review the primary pharmacokinetic properties that drive successful use and delivery of oligonucleotides.The ...
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antisense oligonucleotides (AS-ODNs)

2009
Class of new therapeutics planned for the treatment of viral infections, autoimmune disease, endocrine disease and cancers; AS-ODNs are small synthetic molecules of single-stranded DNA that suppress gene expression by binding to RNA templates in a sequence-specific manner, thus suppressing gene expression, mRNA translation and therefore the production ...
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