Advances in miRNA research: Unraveling the complexities of gene regulation
Animal Models and Experimental Medicine, EarlyView.Overview of miRNA‐mediated regulation in key biological processes. This illustration offers a comprehensive view of the diverse functions that microRNAs perform in governing various biological processes, highlighting their profound significance within the complex web of gene expression and cellular function.
Jiawei Zheng, Guoqing Zhang, Linzhu Ren
wiley +1 more source
Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides. [PDF]
, 1992 Adriana Ferreira +4 more
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Annals of Neurology, EarlyView.Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke +36 more
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Inhibition of gastric cancer cell proliferation by antisense oligonucleotides targeting the messenger RNA encoding proliferating cell nuclear antigen* [PDF]
, 1994 C Sakakura +7 more
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Advanced NanoBiomed Research, EarlyView.Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez +3 more
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Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution [PDF]
, 1991 P.C. de Smidt +3 more
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Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms [PDF]
, 1994 Olivier Zelphati +5 more
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c-myc antisense oligonucleotides inhibit the colony-forming capacity of Colo 320 colonic carcinoma cells. [PDF]
, 1992 James F. Collins +3 more
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mRNA fusion constructs serve in a general cell‐based assay to profile oligonucleotide activity [PDF]
, 2017 A cellular assay has been developed to allow measurement of the inhibitory activity of large numbers of oligonucleotides at the protein level. The assay is centred on an mRNA fusion transcript construct comprising of a full‐length reporter gene with a ...
Asselbergs, Fred +7 more
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Integrin Targeted Delivery of Gene Therapeutics
Theranostics, 2011 Integrins have become key targets for molecular imaging and for selective delivery of anti-cancer agents. Here we review recent work concerning the targeted delivery of antisense and siRNA oligonucleotides via integrins. A variety of approaches have been
Rudy L Juliano, Xin Ming, Osamu Nakagawa, Rongzuo Xu, Hoon Yoo
doaj