Results 121 to 130 of about 275,477 (365)

Antisense Oligonucleotides for the Study and Treatment of ALS

Neurotherapeutics, 2022
Benjamin D. Boros, Kathleen M. Schoch, Collin J Kreple, Timothy A. Miller   +3 more
semanticscholar   +1 more source

Sequences for differential diagnostic of Ehrlichia ruminantium and use thereof [PDF]

, 2006
The invention provides genes that are unique either to Ehrlichia ruminantium strain Gardel or to Ehrlichia ruminantium strain Welgevonden, or allelic couples which are present in both strains but whose sequences differ between the two strains, as genetic
Demaille, Jacques, Ferraz, Conchita, Frutos, Roger, Martinez, Dominique   +3 more
core  

Dependence of aptamer activity on opposed terminal extensions : improvement of light-regulation efficiency [PDF]

, 2009
Aptamers that can be regulated with light allow precise control of protein activity in space and time and hence of biological function in general. In a previous study, we showed that the activity of the thrombin-binding aptamer HD1 can be turned off by ...
Buff, Maximilian, Heckel, Alexander, Mayer, Günter, Müller, Jens, Pötzsch, Bernd, Schäfer, Florian, Wulffen, Bernhard   +6 more
core   +2 more sources

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

Molecular Therapy, 2016
The common chemical and biological properties of antisense oligonucleotides provide the opportunity to identify and characterize chemical class effects across species.
S. Crooke, B. Baker, T. Kwoh, W. Cheng, Dan J Schulz, S. Xia, Nelson Salgado, H. Bui, Christopher E. Hart, S. Burel, H. Younis, R. Geary, S. Henry, S. Bhanot   +13 more
semanticscholar   +1 more source

Targeting STAT3 in Cancer with Nucleotide Therapeutics. [PDF]

, 2019
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for ...
Grandis, Jennifer R, Johnson, Daniel E, Lau, Yue-Ting K, Ramaiyer, Malini   +3 more
core   +2 more sources

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides

Nucleic Acids Research, 2015
Thousands of long non-coding RNAs (lncRNAs) have been identified in mammalian cells. Some have important functions and their dysregulation can contribute to a variety of disease states.
Kim A. Lennox, M. Behlke
semanticscholar   +1 more source

Mcl-1 Antisense Therapy Chemosensitizes Human Melanoma in a SCID Mouse Xenotransplantation Model [PDF]

, 2003
It is well established that high expression of the antiapoptotic Bcl-2 family proteins Bcl-2 and Bcl-xL can significantly contribute to chemoresistance in a number of human malignancies. Much less is known about the role the more recently described Bcl-2
Akgul, Akgul, Bae, Bannerman, Boehm, Brett P. Monia, Brown, Burkhard Jansen, Chao, Christiane Thallinger, Cohen, Conus, Edgar Selzer, Heere-Ress, Helmut Maierhofer, Hockenbery, Hubert Pehamberger, Jansen, Jansen, Jansen, Johnson, Kaufmann, Klaus Wolff, Korsmeyer, Kozopas, Lehmann, Leuenroth, Lowe, Lowe, Makin, Markus F. Wolschek, Monia, Moriishi, Moulding, Moulding, Murphy, Myers, Nicholson, Olie, Patrick Günsberg, Pedersen, Peter Polterauer, Reed, Reed, Reynolds, Reynolds, Rogers, Schubert, Selzer, Serrone, Solary, Strasser, Tang, Thompson, Vaux, Volker Wacheck, Wacheck, Wang, Waters, Webb, Yang, Zhou   +61 more
core   +1 more source

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou   +7 more
wiley   +1 more source