Results 131 to 140 of about 275,477 (365)
International Journal of Nanomedicine, 2016 Despite being a conceptually appealing alternative to conventional antibiotics, a major challenge toward the successful implementation of antisense treatments for bacterial infections is the development of efficient oligonucleotide delivery systems ...
J. Hegarty +5 more
semanticscholar +1 more source
Repair of Aberrant Splicing in Growth Hormone Receptor by Antisense Oligonucleotides Targeting the Splice Sites of a Pseudoexon [PDF]
, 2010 Context: The GH receptor (GHR) pseudoexon 6 Psi defect is a frequent cause of GH insensitivity (GHI) resulting from a non-functioning GH receptor (GHR). It results in a broad range of phenotypes and may also be present in patients diagnosed as idiopathic
Clark, AJL +4 more
core +1 more source
Advanced Science, EarlyView.This study identifies STAU2 as an oncogenic RNA‐binding protein (RBP) with elevated expression in pancreatic ductal adenocarcinoma (PDAC), where its high levels are significantly correlated with metastatic progression. It elucidates that STAU2 directly binds and regulates PALLD, while mediating the functional role of IQGAP1, thereby driving metastasis ...
Jiayu Ding +16 more
wiley +1 more source
Gene Therapy Applications in Gastroenterology and Hepatology
Canadian Journal of Gastroenterology, 2000 Advantages and disadvantages of viral vectors and nonviral vectors for gene delivery to digestive organs are reviewed. Advances in systems for the introduction of new gene expression are described, including self-deleting retroviral transfer vectors ...
Catherine H Wu, Lanlan Shen, George Y Wu
doaj +1 more source
Challenges to oligonucleotides-based therapeutics for Duchenne muscular dystrophy
Skeletal Muscle, 2011 Antisense oligonucleotides are short nucleic acids designed to bind to specific messenger RNAs in order to modulate splicing patterns or inhibit protein translation.
Goyenvalle Aurélie, Davies Kay E
doaj +1 more source
Correction of a Cystic Fibrosis Splicing Mutation by Antisense Oligonucleotides
Human Mutation, 2016 Cystic fibrosis (CF), the most common life‐threatening genetic disease in Caucasians, is caused by ∼2,000 different mutations in the CF transmembrane conductance regulator (CFTR) gene.
Susana Igreja +4 more
semanticscholar +1 more source
Aptamers in oncology: a diagnostic perspective [PDF]
, 2008 Nucleic acid sequences can produce a wide variety of three-dimensional conformations. Some of these structural forms are able to interact with proteins and small molecules with high affinity and specificity.
Khan, Huma, Missailidis, Sotiris
core
Aggregate, EarlyView.A self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA), termed TACs, enables localized accumulation and sustained release of ceftriaxone while co‐delivering antisense oligonucleotides that silence mecA, reduce PBP2a expression, and restore β‐lactam susceptibility in MRSA.
Yicheng Zhao +10 more
wiley +1 more source
Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes [PDF]
, 1994 Xenopus oocytes were used to examine the coupling of the serotonin 1c (5HT1c) and thyrotropin-releasing hormone (TRH) receptors to both endogenous and heterologously expressed G protein alpha subunits.
Aragay, Anna M. +4 more
core
Antisense Oligonucleotides, microRNAs, and Antibodies [PDF]
, 2014 The specificity of Watson-Crick base pairing and the development of several chemical modifications to oligonucleotides have enabled the development of novel drug classes for the treatment of different human diseases. This review focuses on promising results of recent preclinical or clinical studies on targeting HDL metabolism and function by antisense ...
Alberto Dávalos, Angeliki Chroni
openaire +3 more sources