Results 131 to 140 of about 127,002 (321)
Reply to “Extending the Interpretation of Biomarker Dynamics in SOD1‐ALS Proteomics”
Annals of Neurology, EarlyView.
Christina Steffke +2 more
wiley +1 more source
Mini‐Hairpin DNA: Extraordinarily Stable Structure and Its Applications
Chemistry – A European Journal, EarlyView.Mini‐hairpin DNA fragments containing GCGAAGC and GCGAAAGC form exceptionally stable hairpin‐like structures, with only two G−C pairs and one sheared G−A pair, remaining undenatured in 7 M urea and resisting nuclease digestion. These mini‐hairpin sequences frequently appear in replication and transcription origins, influence DNA sequencing fidelity ...
Michiko Kimoto, Ichiro Hirao
wiley +1 more source
Integrin Targeted Delivery of Gene Therapeutics
Theranostics, 2011 Integrins have become key targets for molecular imaging and for selective delivery of anti-cancer agents. Here we review recent work concerning the targeted delivery of antisense and siRNA oligonucleotides via integrins. A variety of approaches have been
Rudy L Juliano, Xin Ming, Osamu Nakagawa, Rongzuo Xu, Hoon Yoo
doaj
Epilepsy Phenotypic Spectrum of NUS1‐Related Disorder: A Case Series
Annals of the Child Neurology Society, EarlyView.ABSTRACT Background Epilepsy with myoclonic and atonic seizures (EMAtS), also known as Doose syndrome, accounts for 1%–2% of childhood epilepsies, and various genes have been implicated in causing this epilepsy syndrome. NUS1 encodes for Nogo‐B receptor (NgBR), which stabilizes the dehydrodolichyl‐diphosphate synthase complex in the endoplasmic ...
Saumel Ahmadi +6 more
wiley +1 more source
Antisense oligonucleotides targeted against protein kinase c α inhibit proliferation of cultured avian myoblasts [PDF]
, 2000 Daniela Andrea Capiati +3 more
openalex +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.The FDA published guidance on assessing pharmacokinetics (PK) in participants with impaired renal function in 2024. The IQ CPLG Organ Impairment Working Group summarized the industry’s perspective on this guidance by highlighting a few key updates in the 2024 guidance, including: (1) the recommendation of using estimated glomerular filtration rate ...
Yan Jin +13 more
wiley +1 more source
Antisense oligonucleotide eluforsen improves CFTR function in F508del cystic fibrosis [PDF]
, 2018 Isabelle Sermet‐Gaudelus +14 more
openalex +1 more source
Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes
Epilepsia Open, EarlyView.Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola +3 more
wiley +1 more source
Sensitivity of splice sites to antisense oligonucleotides in vivo [PDF]
, 1999 Halina Sierakowska +3 more
openalex +1 more source
Androgen Receptor Antisense Oligonucleotide AZD5312 [PDF]
, 2020 National Cancer Institute
openalex +1 more source