Results 21 to 30 of about 120,043 (332)

Antisense oligonucleotides for the arterial hypertension mechanisms study and therapy

Вавиловский журнал генетики и селекции, 2018
Arterial hypertension is one of the most common chronic diseases in adults all over the world. This pathology can not only reduce patients’ life quality, but can also be accompanied by a number of complications.
L. O. Klimov, A. A. Seryapina, V. F. Zarytova, A. S. Levina, A. L. Markel   +4 more
doaj   +1 more source

Design of a nanobiosystem with remote photothermal gene silencing in Chlamydomonas reinhardtii to increase lipid accumulation and production

Microbial Cell Factories, 2023
Research development in the precise control of gene expression in plant cells is an emerging necessity that would lead to the elucidation of gene function in these biological systems.
Hossein Alishah Aratboni, Nahid Rafiei, Ashanti Concepción Uscanga-Palomeque, Itza Eloisa Luna Cruz, Roberto Parra-Saldivar, Jose Ruben Morones-Ramirez   +5 more
doaj   +1 more source

Targeting FMN, TPP, SAM-I, and glmS Riboswitches with Chimeric Antisense Oligonucleotides for Completely Rational Antibacterial Drug Development

Antibiotics, 2023
Antimicrobial drug resistance has emerged as a significant challenge in contemporary medicine due to the proliferation of numerous bacterial strains resistant to all existing antibiotics.
Nikolet Pavlova, Martina Traykovska, Robert Penchovsky   +2 more
doaj   +1 more source

Targeting TGFβ Signaling to Address Fibrosis Using Antisense Oligonucleotides

Biomedicines, 2018
Fibrosis results from the excessive accumulation of extracellular matrix in chronically injured tissue. The fibrotic process is governed by crosstalk between many signaling pathways.
James T. March, Golnoush Golshirazi, Viktorija Cernisova, Heidi Carr, Yee Leong, Ngoc Lu-Nguyen, Linda J. Popplewell   +6 more
doaj   +1 more source

Effect of native gastric mucus on in vivo hybridization therapies directed at Helicobacter pylori [PDF]

, 2015
Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H.
Azevedo, Nuno F, Braeckmans, Kevin, Dakwar, George, De Smedt, Stefaan, Figueiredo, Céu, Fontenete, Silvia, Forier, Katrien, Guimarães, Nuno, Leite, Marina, Remaut, Katrien, Santos, Rita, Stremersch, Stephan, Wengel, Jesper, Xiong, Ranhua   +13 more
core   +10 more sources

Consequences of Making the Inactive Active Through Changes in Antisense Oligonucleotide Chemistries

Frontiers in Genetics, 2019
Antisense oligonucleotides are short, single-stranded nucleic acid analogues that can interfere with pre-messenger RNA (pre-mRNA) processing and induce excision of a targeted exon from the mature transcript.
Khine Zaw, Khine Zaw, Kane Greer, Kane Greer, May Thandar Aung-Htut, May Thandar Aung-Htut, Chalermchai Mitrpant, Chalermchai Mitrpant, Rakesh N. Veedu, Rakesh N. Veedu, Sue Fletcher, Sue Fletcher, Steve D. Wilton, Steve D. Wilton   +13 more
doaj   +1 more source

Generation of Choline for Acetylcholine Synthesis by Phospholipase D Isoforms [PDF]

, 2001
DEDICATION: This article is dedicated to the memory of Sue Kim Hanson, a graduate student in the department of Pathology and Laboratory Medicine at Boston University School of Medicine, who perished in the terrorist attacks of September 11, 2001 ...
Blusztajn, Jan Krzysztof, Frohman, Michael A, Zhao, Di   +2 more
core   +3 more sources

Taking control of gene expression with light-activated oligonucleotides

BioTechniques, 2007
The recent development of caged oligonucleotides that are efficiently activated by ultraviolet (UV) light creates opportunities for regulating gene expression with very high spatial and temporal resolution.
Ivan J. Dmochowski, XinJing Tang
doaj   +1 more source

Synthesis and anti-HIV activity of thiocholesteryl-coupled phosphodiester antisense oligonucleotides incorporated into immunoliposomes [PDF]

, 1994
Encapsulation of oligonucleotides in antibody-targeted liposomes (immunoliposomes) which bind to target cells permits intracellular delivery of the oligonucleotides.
Akhtar, Akhtar, Barré-Sinoussi, Boutorine, Boutorine, Boutorine, Boutorine, de Smidt, Feener, Gamper, Goodchild, Hope, Kabanov, Kim, Kinchington, Krieg, Lemke, Leonetti, Leserman, Leserman, Letsinger, Loke, Machy, Machy, Machy, Matsukura, Matthay, Oberhauser, Rebaï, Rey, Saison-Behmoaras, Senior, Shaw, Shea, Stein, Stewart, Suzuki, Svinarchuk, Thierry, Uhlmann, Yakubov, Zamecnik, Zelphati   +42 more
core   +1 more source

Locked nucleic acid: tighter is different [PDF]

, 2013
This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity ...
Watts, Jonathan
core   +1 more source