Results 21 to 30 of about 124,170 (327)
Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer Therapeutics
Molecular Therapy: Nucleic Acids, 2019 Cancer is one of the leading causes of death worldwide, and conventional cancer therapies such as surgery, chemotherapy, and radiotherapy do not address the underlying molecular pathologies, leading to inadequate treatment and tumor recurrence ...
Bao T. Le +5 more
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Cell Reports, 2021 Summary: Activation of the pro-degenerative protein SARM1 after diverse physical and disease-relevant injuries causes programmed axon degeneration. Original studies indicate that substantially decreased SARM1 levels are required for neuroprotection ...
Stacey Anne Gould +5 more
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Targeting TGFβ Signaling to Address Fibrosis Using Antisense Oligonucleotides
Biomedicines, 2018 Fibrosis results from the excessive accumulation of extracellular matrix in chronically injured tissue. The fibrotic process is governed by crosstalk between many signaling pathways.
James T. March +6 more
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Microbial Cell Factories, 2023 Research development in the precise control of gene expression in plant cells is an emerging necessity that would lead to the elucidation of gene function in these biological systems.
Hossein Alishah Aratboni +5 more
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Antibiotics, 2023 Antimicrobial drug resistance has emerged as a significant challenge in contemporary medicine due to the proliferation of numerous bacterial strains resistant to all existing antibiotics.
Nikolet Pavlova +2 more
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Generation of Choline for Acetylcholine Synthesis by Phospholipase D Isoforms [PDF]
, 2001 DEDICATION: This article is dedicated to the memory of Sue Kim Hanson, a graduate student in the department of Pathology and Laboratory Medicine at Boston University School of Medicine, who perished in the terrorist attacks of September 11, 2001 ...
Blusztajn, Jan Krzysztof +2 more
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Antisense oligonucleotides for the arterial hypertension mechanisms study and therapy
Вавиловский журнал генетики и селекции, 2018 Arterial hypertension is one of the most common chronic diseases in adults all over the world. This pathology can not only reduce patients’ life quality, but can also be accompanied by a number of complications.
L. O. Klimov +4 more
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Regulation of metabolism by miR-378 [PDF]
, 2014 The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
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Consequences of Making the Inactive Active Through Changes in Antisense Oligonucleotide Chemistries
Frontiers in Genetics, 2019 Antisense oligonucleotides are short, single-stranded nucleic acid analogues that can interfere with pre-messenger RNA (pre-mRNA) processing and induce excision of a targeted exon from the mature transcript.
Khine Zaw +13 more
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Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake [PDF]
, 2016 Indexación: Web of Science.Poly(amidoamine) dendrimers are the most recognized class of dendrimer. Amino-terminated (PAMAM-NH2) and hydroxyl-terminated (PAMAM-OH) dendrimers of generation 4 are widely used, since they are commercially available.
Araya-Durán, Ingrid +10 more
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