Results 311 to 320 of about 124,170 (327)
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Antisense oligonucleotide strategies in physiology
Molecular and Cellular Endocrinology, 1994Antisense oligonucleotides can inhibit gene expression in living cells by binding to complementary sequences of DNA, RNA or mRNA. The mechanisms include inhibition of RNA synthesis, RNA splicing, mRNA export, binding of initiation factors, assembly of ribosome subunits and of sliding of the ribosome along the mRNA coding sequence.
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The concept and application of antisense oligonucleotides
Diseases of the Colon & Rectum, 2001Since the identification of the double-stranded DNA helix by Watson and Crick in 1953, the knowledge of nucleotide structure and function has been an important potential tool in the study and therapy of disease. There is recent clinical evidence that antisense oligonucleotides may be important therapeutic compounds in the clinical therapy of a range of
Stanley T. Crooke, Bruce R. Yacyshyn
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Antisense Oligonucleotides as Research Tools
2003The use of antisense oligonucleotides as both research tools and therapeutic molecules has emerged as a powerful alternative to small molecule inhibitors. Antisense oligonucleotides are short pieces of chemically modified DNA designed to hybridize to specific mRNA sequences present in the target gene.
Nicholas M. Dean +2 more
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Antisense Oligonucleotides: The State of the Art
Current Medicinal Chemistry, 2005The use of antisense oligonucleotides as therapeutic agents has generated considerable enthusiasm in the research and medical community. Antisense oligonucleotides as therapeutic agents were proposed as far back as in the 1970s when the antisense strategy was initially developed.
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Innovations in the Use of Antisense Oligonucleotides
Annals of the New York Academy of Sciences, 1990The use of antisense oligonucleotides for controlling genetic expression has recently received widespread attention, especially as a new class of potential chemotherapeutic agents. This coupled with the urgency of developing new effective therapies for acquired immunodeficiency syndrome (AIDS) has led to various antisense studies dealing with human ...
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Antisense oligonucleotide pharmacokinetics and metabolism
Expert Opinion on Drug Metabolism & Toxicology, 2009The use of oligonucleotides as therapeutic agents has elicited a great deal of interest. Basic understanding and evaluation of the pharmacokinetic properties of oligonucleotides is foundational to their appropriate design and application.To review the primary pharmacokinetic properties that drive successful use and delivery of oligonucleotides.The ...
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antisense oligonucleotides (AS-ODNs)
2009Class of new therapeutics planned for the treatment of viral infections, autoimmune disease, endocrine disease and cancers; AS-ODNs are small synthetic molecules of single-stranded DNA that suppress gene expression by binding to RNA templates in a sequence-specific manner, thus suppressing gene expression, mRNA translation and therefore the production ...
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Antisense Oligonucleotides as Antiviral Agentsa
Annals of the New York Academy of Sciences, 1992Alan D. B. Malcolm, Judy M. Coulson
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An Antisense Oligonucleotide Primer
Antisense and Nucleic Acid Drug Development, 1999openaire +3 more sources
Antisense oligonucleotide therapeutics
Expert Opinion on Investigational Drugs, 1999openaire +3 more sources