Results 331 to 340 of about 275,477 (365)

Antisense oligonucleotides in cutaneous therapy

Pharmacology & Therapeutics, 2001
Antisense oligonucleotides have been the subject of intense interest as research tools to elucidate the functions of gene products and as therapeutic agents. Initially, their mode of action was poorly understood and the biological effects of oligonucleotides were often misinterpreted.
Paul J. White, Christopher J. Wraight
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Antisense Oligonucleotides: Promise and Reality

Annual Review of Pharmacology and Toxicology, 2001
Antisense oligonucleotides have been used for more than a decade to downregulate gene expression. Phosphodiester oligonucleotides are nuclease sensitive, and the more nuclease-resistant phosphorothioate oligonucleotides are now in common use in the laboratory and have entered clinical trials.
Cy A. Stein, Irina V. Lebedeva
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Antisense Anticancer Oligonucleotide Therapeutics

Current Cancer Drug Targets, 2001
Recent progress made in molecular biology, biotechnology, and genetics, especially in identifying, cloning, sequencing and characterization of normal and pathogenic genes, has led to the development of genetic therapy. Major efforts in the field can be summarized in two general approaches: gene therapy and antisense therapy. The second is to deliver to
Gautam Prasad, Hui Wang, Ruiwen Zhang, John K. Buolamwini   +3 more
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Antisense Oligonucleotide Therapy in Urology

Journal of Urology, 2002
Antisense oligonucleotides are short modified DNA or RNA molecules designed to bind selectively messenger RNA and inhibit synthesis of the encoded protein. In the last 20 years antisense technology has emerged as an exciting and promising strategy, especially for treating cancer.
Ingo Kausch, A. Böhle
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Progress in Antisense Oligonucleotide Therapeutics

Annual Review of Pharmacology and Toxicology, 1996
The past several years have seen substantial progress in the development of antisense oligonucleotides as pharmacological tools and as therapeutic agents. With properly designed and executed experiments, it has been possible to demonstrate selective inhibition of gene expression, owing to an antisense mechanisms of action both in cell culture-based ...
Stanley T. Crooke, C F Bennett
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Mini-antisense Oligonucleotides

Nucleosides and Nucleotides, 1997
Abstract A new strategy of selective DNA target modification was proposed. The using of reactive derivatives of short oligonucleotides in the presence of flanking effector pair allows one to modify DNA target only when the perfect complementary complex of DNA target and oligonucleotide tandem is formed.
Dmitrii V. Pyshnyi, Valentina F. Zarytova, Lokhov Sg, Inna A. Pyshnaya, E. M. Ivanova   +4 more
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Antisense Oligonucleotides as Research Tools

2003
The use of antisense oligonucleotides as both research tools and therapeutic molecules has emerged as a powerful alternative to small molecule inhibitors. Antisense oligonucleotides are short pieces of chemically modified DNA designed to hybridize to specific mRNA sequences present in the target gene.
Nicholas M. Dean, Scott Cooper, Jennifer K. Taylor   +2 more
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Comparative Renal Toxicopathology of Antisense Oligonucleotides.

Nucleic Acid Therapeutics, 2016
This review summarizes the current understanding of nephrotoxicity related to the administration of therapeutic oligonucleotides, particularly those with 2'-methoxy-ethyl (2'-MOE) modifications.
J. Engelhardt
semanticscholar   +1 more source

Specificity of antisense oligonucleotides

Perspectives in Drug Discovery and Design, 1996
Antisense oligodeoxynucleotides that are sufficiently long to specify unique species of mRNA may direct ribonuclease H (RNase H) to cleave nontargeted mRNAs at sites of partial complementarity, both in cell-free systems and in living cells. Specificity of antisense action against selected gene expression may be achieved by increasing the stringency of ...
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The concept and application of antisense oligonucleotides

Diseases of the Colon & Rectum, 2001
Since the identification of the double-stranded DNA helix by Watson and Crick in 1953, the knowledge of nucleotide structure and function has been an important potential tool in the study and therapy of disease. There is recent clinical evidence that antisense oligonucleotides may be important therapeutic compounds in the clinical therapy of a range of
Stanley T. Crooke, Bruce R. Yacyshyn
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