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Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination [PDF]

Molecular Cell, 2020
Antisense oligonucleotides (ASOs) that trigger RNase-H-mediated cleavage are commonly used to knock down transcripts for experimental or therapeutic purposes. In particular, ASOs are frequently used to functionally interrogate long noncoding RNAs (lncRNAs) and discriminate lncRNA loci that produce functional RNAs from those whose activity is ...
Joshua T Mendell, Jong-Sun Lee
exaly   +3 more sources

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Natural antisense transcripts in fungi

Molecular Microbiology, 2012
SummaryFungi are models for investigating many eukaryotic molecular processes. The identification of natural antisense transcripts (NATs) in fungi led to the discovery of mechanisms for controlling gene expression through transcriptional interference, chromatin remodelling and dsRNA formation.
Michael E, Donaldson, Barry J, Saville
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Antisense transcripts in the human genome

Trends in Genetics, 2002
By a systematic search of vertebrate mRNA sequences, we have identified a surprisingly large number of human antisense transcripts. These data suggest that regulation of gene expression by antisense and double-stranded RNAs could be a common phenomenon in mammalian cells.
Ben, Lehner, Gary, Williams, R Duncan, Campbell, Christopher M, Sanderson   +3 more
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Transcriptional Regulation of Msx1 Natural Antisense Transcript

Cells Tissues Organs, 2011
Msx homeogenes play an important role in the epithelial-mesenchymal interactions leading development. Msx1 is relevant for dental and craniofacial morphogenesis, as suggested by phenotypes of Msx1 mutations in human and Msx1 KO mice. Our group showed that Msx1 gene expression can be regulated by a bidirectional transcription generating long noncoding ...
Sylvie, Babajko, Fleur, Méary, Stéphane, Petit, Isabelle, Fernandes, Ariane, Berdal   +4 more
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Strategies to identify natural antisense transcripts

Biochimie, 2017
Natural antisense transcripts, originally considered as transcriptional noises arising from so-called "junk DNA″, are recently recognized as important modulators for gene regulation. They are prevalent in nearly all realms of life and have been found to modulate gene expression positively or negatively. By affecting almost all stages of gene expression
Yulong, Sun, Dijie, Li, Ru, Zhang, Shang, Peng, Ge, Zhang, Tuanmin, Yang, Airong, Qian   +6 more
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Natural Antisense Transcripts in Bacteria

2012
This chapter focuses on special types of transcripts, those which originate from the complementary strand of an mRNA or functional RNA. As a consequence, these RNA molecules are, partially or to the extent of their full length, complementary to their target.
Georg, Jens, Hess, Wolfgang
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Destabilization ofrbcS sense transcripts by antisense RNA

Plant Molecular Biology, 1994
Steady-state rbcS mRNA levels are drastically reduced in transgenic tobacco plants that express rbcS antisense RNAs. We have found that these reductions are not due to an effect of the antisense RNA at the level of rbcS transcription; rather, the sense mRNAs are more actively degraded in the mutant than wild-type plants.
C Z, Jiang, D, Kliebenstein, N, Ke, S, Rodermel   +3 more
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Chromatin remodelling at promoters suppresses antisense transcription

Nature, 2007
Chromatin allows the eukaryotic cell to package its DNA efficiently. To understand how chromatin structure is controlled across the Saccharomyces cerevisiae genome, we have investigated the role of the ATP-dependent chromatin remodelling complex Isw2 in positioning nucleosomes.
Iestyn, Whitehouse, Oliver J, Rando, Jeff, Delrow, Toshio, Tsukiyama   +3 more
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HOX transcript antisense RNA (HOTAIR) in cancer

Cancer Letters, 2019
Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of cancer. The lncRNA HOX transcript antisense RNA (HOTAIR) is a prime example of an oncogenic trans-acting lncRNA. The expression of HOTAIR is elevated in a broad spectrum of cancers and is associated with metastasis and poor prognosis.
Xiaohan Qu, Simon Alsager, Ying Zhuo, Bin Shan   +3 more
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Pervasive antisense transcription is evolutionarily conserved in budding yeast.

Molecular Biology and Evolution, 2013
Evan Daugharthy, Junhyong Kim
exaly