Results 1 to 10 of about 2,242,574 (332)
HIV-1-encoded antisense RNA suppresses viral replication for a prolonged period
Retrovirology, 2012 Background Recent evidence proposes a novel concept that mammalian natural antisense RNAs play important roles in cellular homeostasis by regulating the expression of several genes.
Kobayashi-Ishihara Mie +9 more
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Antisense RNA: the new favorite in genetic research
Journal of Zhejiang University: Science B, 2018 Antisense RNA molecule represents a unique type of DNA transcript that comprises 19–23 nucleotides and is complementary to mRNA. Antisense RNAs play the crucial role in regulating gene expression at multiple levels, such as at replication, transcription,
Jianzhong Xu +2 more
exaly +2 more sources
RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs
Cells, 2020 The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in 1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was United States Food and Drug Administration (FDA) approved. This promises to
Sarah Bajan, Gyorgy Hutvagner
exaly +2 more sources
Definitions, 2020 IGF2 Antisense RNA (~2 kb) is encoded by the human IGF2-AS gene. This non-coding RNA is involved in Wilms tumor and may play a role in renal development.
openaire +2 more sources
Making sense of Dlx1 antisense RNA
Developmental Biology, 2013 Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer.
Kraus, Petra +5 more
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From Antisense RNA to RNA Modification: Therapeutic Potential of RNA-Based Technologies
Biomedicines, 2021 Therapeutic oligonucleotides interact with a target RNA via Watson-Crick complementarity, affecting RNA-processing reactions such as mRNA degradation, pre-mRNA splicing, or mRNA translation.
H. Adachi +3 more
semanticscholar +1 more source
RNAi screen indicates widespread biological function for human natural antisense transcripts. [PDF]
PLoS ONE, 2010 Natural antisense transcripts represent a class of regulatory RNA molecules, which are characterized by their complementary sequence to another RNA transcript.
Mohammad Ali Faghihi +8 more
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Functionalization of an Antisense Small RNA [PDF]
Journal of Molecular Biology, 2016 In order to explore the possibility of adding new functions to preexisting genes, we considered a framework of riboregulation. We created a new riboregulator consisting of the reverse complement of a known riboregulator. Using computational design, we engineered a cis-repressing 5' untranslated region that can be activated by this new riboregulator. As
Rodrigo, Guillermo +4 more
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Technology in Cancer Research & Treatment, 2020 Background: PTPRG antisense RNA 1 has been well-documented to exert an oncogenic role in diverse neoplasms. However, the precise role of PTPRG antisense RNA 1 in regulating radiosensitivity of nonsmall cell lung cancer cells remains largely elusive ...
Qiang Ma MB +7 more
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Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD
Molecules, 2020 The hexanucleotide expansion GGGGCC located in C9orf72 gene represents the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD).
Tim Božič +4 more
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