Results 11 to 20 of about 2,242,574 (332)
Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics [PDF]
, 2008 Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene.
Alirio J. Melendez +3 more
core +8 more sources
Recent insights into the functions and mechanisms of antisense RNA: emerging applications in cancer therapy and precision medicine [PDF]
Frontiers in Chemistry, 2023 The antisense RNA molecule is a unique DNA transcript consisting of 19–23 nucleotides, characterized by its complementary nature to mRNA. These antisense RNAs play a crucial role in regulating gene expression at various stages, including replication ...
Shahab Ur Rehman +8 more
doaj +2 more sources
Antisense RNA Therapeutics: A Brief Overview [PDF]
Methods Mol Biol, 2022 AbstractNucleic acid therapeutics is a growing field aiming to treat human conditions that has gained special attention due to the successful development of mRNA vaccines against SARS-CoV-2. Another type of nucleic acid therapeutics is antisense oligonucleotides, versatile tools that can be used in multiple ways to target pre-mRNA and mRNA.
Virginia Arechavala-Gomeza +1 more
openaire +4 more sources
, 2001 This communication describes improvement strategies used on a previously described two-unit antisense RNA cassette system. This cassette system encodes RNA with noncontiguous regions of complementarity to a bacterial target RNA, lad mRNA, One of the ...
Wagner, EGH, Engdahl, HM,, Lindell, M
core +9 more sources
Nature Structural & Molecular Biology, 2021 Drug discovery campaigns against COVID-19 are beginning to target the SARS-CoV-2 RNA genome. The highly conserved frameshift stimulation element (FSE), required for balanced expression of viral proteins, is a particularly attractive SARS-CoV-2 RNA target.
Kaiming Zhang +18 more
semanticscholar +1 more source
Antisense RNA based down-regulation of RNaseE in
Microbial Cell Factories, 2006 Background Messenger RNA decay is an important mechanism for controlling gene expression in all organisms. The rate of the mRNA degradation directly affects the steady state concentration of mRNAs and therefore influences the protein synthesis.
Neubauer Peter, Kemmer Christian
doaj +1 more source
Increasing the Editing Efficiency of the MS2-ADAR System for Site-Directed RNA Editing
Applied Sciences, 2023 Site-directed RNA editing (SDRE) technologies have great potential in gene therapy. Our group has developed a strategy to redirect exogenous adenosine deaminases acting on RNA (ADARs) to specific sites by making editable structures using antisense RNA ...
Jiarui Li +4 more
doaj +1 more source
Identification and characterization of a cis-encoded antisense RNA associated with the replication process of Salmonella enterica serovar Typhi. [PDF]
PLoS ONE, 2013 Antisense RNAs that originate from the complementary strand of protein coding genes are involved in the regulation of gene expression in all domains of life.
Isaac Dadzie +7 more
doaj +1 more source
Nature Communications, 2018 Long non-coding RNAs (lncRNAs) have emerged as important regulators of gene expression and plant development. Here, we identified 6,510 lncRNAs in Arabidopsis under normal or stress conditions.
Xinyue Zhao +5 more
semanticscholar +1 more source
Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]
, 2010 For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
core +3 more sources