RNA silencing and HIV: A hypothesis for the etiology of the severe combined immunodeficiency induced by the virus [PDF]
Retrovirology, 2008 A novel intrinsic HIV-1 antisense gene was previously described with RNA initiating from the region of an HIV-1 antisense initiator promoter element (HIVaINR). The antisense RNA is exactly complementary to HIV-1 sense RNA and capable of forming ~400 base-
Ludwig Linda B
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Functionalization of an Antisense Small RNA [PDF]
Journal of Molecular Biology, 2016 In order to explore the possibility of adding new functions to preexisting genes, we considered a framework of riboregulation. We created a new riboregulator consisting of the reverse complement of a known riboregulator. Using computational design, we engineered a cis-repressing 5' untranslated region that can be activated by this new riboregulator. As
Rodrigo, Guillermo +4 more
openaire +8 more sources
RNAi screen indicates widespread biological function for human natural antisense transcripts. [PDF]
PLoS ONE, 2010 Natural antisense transcripts represent a class of regulatory RNA molecules, which are characterized by their complementary sequence to another RNA transcript.
Mohammad Ali Faghihi +8 more
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Technology in Cancer Research & Treatment, 2020 Background: PTPRG antisense RNA 1 has been well-documented to exert an oncogenic role in diverse neoplasms. However, the precise role of PTPRG antisense RNA 1 in regulating radiosensitivity of nonsmall cell lung cancer cells remains largely elusive ...
Qiang Ma MB +7 more
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Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD
Molecules, 2020 The hexanucleotide expansion GGGGCC located in C9orf72 gene represents the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD).
Tim Božič +4 more
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A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. [PDF]
, 2016 Gonadotropin-releasing hormone (GnRH), a neuropeptide released from a small population of neurons in the hypothalamus, is the central mediator of the hypothalamic-pituitary-gonadal axis, and is required for normal reproductive development and function ...
Brusman, Liza E +4 more
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Increasing the Editing Efficiency of the MS2-ADAR System for Site-Directed RNA Editing
Applied Sciences, 2023 Site-directed RNA editing (SDRE) technologies have great potential in gene therapy. Our group has developed a strategy to redirect exogenous adenosine deaminases acting on RNA (ADARs) to specific sites by making editable structures using antisense RNA ...
Jiarui Li +4 more
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Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA. [PDF]
, 1985 The bacteriophage SP6 promoter and RNA polymerase were used to synthesize sense and antisense RNAs coding for the enzymes thymidine kinase (TK) and chloramphenicol acetyl transferase (CAT).
HARLAND, Richard M., Weintraub, H
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Antisense RNA based down-regulation of RNaseE in
Microbial Cell Factories, 2006 Background Messenger RNA decay is an important mechanism for controlling gene expression in all organisms. The rate of the mRNA degradation directly affects the steady state concentration of mRNAs and therefore influences the protein synthesis.
Neubauer Peter, Kemmer Christian
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Identification and characterization of a cis-encoded antisense RNA associated with the replication process of Salmonella enterica serovar Typhi. [PDF]
PLoS ONE, 2013 Antisense RNAs that originate from the complementary strand of protein coding genes are involved in the regulation of gene expression in all domains of life.
Isaac Dadzie +7 more
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