AUG-Dependent Translation of Antisense Repeat Transcripts Contributes to Dipeptide Repeat Protein Production in C9ORF72 Expansion Carriers [PDF]
CellsA hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Sandra Almeida +2 more
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High levels of antisense transcription from numerous genes in the obligate intracellular bacterium Orientia tsutsugamushi [PDF]
Journal of BacteriologyOrientia tsutsugamushi (Ot) is a cytoplasmic, gram-negative, obligate intracellular bacterium that causes the human disease scrub typhus. It has a highly repetitive genome, whereby approximately 50% is composed of multiple copies of a proliferated ...
Chitrasak Kullapanich +3 more
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RNAi screen indicates widespread biological function for human natural antisense transcripts. [PDF]
PLoS ONE, 2010 Natural antisense transcripts represent a class of regulatory RNA molecules, which are characterized by their complementary sequence to another RNA transcript.
Mohammad Ali Faghihi +8 more
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Technology in Cancer Research & Treatment, 2020 Background: PTPRG antisense RNA 1 has been well-documented to exert an oncogenic role in diverse neoplasms. However, the precise role of PTPRG antisense RNA 1 in regulating radiosensitivity of nonsmall cell lung cancer cells remains largely elusive ...
Qiang Ma MB +7 more
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Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD
Molecules, 2020 The hexanucleotide expansion GGGGCC located in C9orf72 gene represents the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD).
Tim Božič +4 more
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Antisense RNA based down-regulation of RNaseE in
Microbial Cell Factories, 2006 Background Messenger RNA decay is an important mechanism for controlling gene expression in all organisms. The rate of the mRNA degradation directly affects the steady state concentration of mRNAs and therefore influences the protein synthesis.
Neubauer Peter, Kemmer Christian
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Increasing the Editing Efficiency of the MS2-ADAR System for Site-Directed RNA Editing
Applied Sciences, 2023 Site-directed RNA editing (SDRE) technologies have great potential in gene therapy. Our group has developed a strategy to redirect exogenous adenosine deaminases acting on RNA (ADARs) to specific sites by making editable structures using antisense RNA ...
Jiarui Li +4 more
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Identification and characterization of a cis-encoded antisense RNA associated with the replication process of Salmonella enterica serovar Typhi. [PDF]
PLoS ONE, 2013 Antisense RNAs that originate from the complementary strand of protein coding genes are involved in the regulation of gene expression in all domains of life.
Isaac Dadzie +7 more
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HIV-1-encoded antisense RNA suppresses viral replication for a prolonged period
Retrovirology, 2012 Background Recent evidence proposes a novel concept that mammalian natural antisense RNAs play important roles in cellular homeostasis by regulating the expression of several genes.
Kobayashi-Ishihara Mie +9 more
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Use of Internal Controls to Increase Quantitative Capabilities of the Ribonuclease Protection Assay
BioTechniques, 1997 Through the use of two internal controls, we have developed an improved method of quantitating ribonuclease protection assay (RPA) results. A truncated sense RNA fragment and an antisense RNA fragment for the gene of interest were transcribed from PCR ...
Mary Jo J. Davis +2 more
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