Results 11 to 20 of about 959,158 (292)
Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics [PDF]
, 2008 Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene.
Alirio J. Melendez +3 more
core +8 more sources
, 2001 This communication describes improvement strategies used on a previously described two-unit antisense RNA cassette system. This cassette system encodes RNA with noncontiguous regions of complementarity to a bacterial target RNA, lad mRNA, One of the ...
Wagner, EGH, Engdahl, HM,, Lindell, M
core +9 more sources
Functionalization of an Antisense Small RNA [PDF]
Journal of Molecular Biology, 2016 In order to explore the possibility of adding new functions to preexisting genes, we considered a framework of riboregulation. We created a new riboregulator consisting of the reverse complement of a known riboregulator. Using computational design, we engineered a cis-repressing 5' untranslated region that can be activated by this new riboregulator. As
Rodrigo, Guillermo +4 more
openaire +7 more sources
Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]
, 2010 For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
core +3 more sources
Antisense RNA Design, Delivery, and Analysis [PDF]
, 2022 This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention.
core +2 more sources
Retrovirology, 2006 Background While viruses have long been shown to capitalize on their limited genomic size by utilizing both strands of DNA or complementary DNA/RNA intermediates to code for viral proteins, it has been assumed that human retroviruses have all their major
Hsiao Chiu-Bin +6 more
doaj +1 more source
The application of antisense technology for crop improvement: A review
Cogent Food & Agriculture, 2021 The global population is increasing alarmingly, which calls for efficient methods of food production. Since domestication, people have been working on improving food crops for production and productivity.
Tadesse Tilahun +3 more
doaj +1 more source
Cell Transplantation, 2012 Tissue factor (TF) expression on islets has been shown to trigger instant blood-mediated inflammatory reaction (IBMIR), leading to rapid islet loss in portal vein islet transplantation.
Xiaoqian Ma +8 more
doaj +1 more source
Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA
Nature Communications, 2023 The expanded hexanucleotide GGGGCC repeat mutation in the C9orf72 gene is the main genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia.
Mirjana Malnar Črnigoj +10 more
doaj +1 more source
Meeting review : ESF workshop on "Impact of nucleic acid chemistry on gene function analysis: antisense, aptamers, ribozymes and RNAi" [PDF]
, 2008 The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function ...
Prydz, Hans +3 more
core +1 more source