Results 21 to 30 of about 959,158 (292)

An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]

, 2013
Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Darren M. Gowers (485354), Jack O Phillips, Anastasia J Callaghan, Vincent, H., Andrew R. Pickford (485355), Adam J Roberts, Louise E. Butt (485353), Stone, Carlanne, Charlotte E. Mardle (485352), Henderson, Charlotte, Adam J. Roberts (485350), Pickford, Andy, Carlanne M Stone, Roberts, Adam J., Butt, Louise, Charlotte A Henderson, Louise E Butt, Anastasia J. Callaghan (485356), Helen A Vincent, Charlotte E Mardle, Callaghan, Anastasia, Carlanne M. Stone (485351), Phillips, Jack, Jack O. Phillips (485348), Charlotte A. Henderson (485349), Gowers, Darren, Mardle, C., Andrew R Pickford, Helen A. Vincent (485347), Darren M Gowers   +29 more
core   +2 more sources

Identification and Characterization of a Cis Antisense RNA of the rpoH Gene of Salmonella enterica Serovar Typhi

Frontiers in Microbiology, 2018
Antisense RNAs from complementary strands of protein coding genes regulate the expression of genes involved in many cellular processes. Using deep sequencing analysis of the Salmonella enterica serovar Typhi (S.
Changyan Xiong, Changyan Xiong, Xuejiao Li, Xuejiao Li, Juanli Liu, Xin Zhao, Shungao Xu, Xinxiang Huang   +7 more
doaj   +1 more source

RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications. [PDF]

PLoS ONE, 2015
The inhibitory potency of an antisense oligonucleotide depends critically on its design and the accessibility of its target site. Here, we used an RNA interference-guided approach to select antisense oligonucleotide target sites in the coding region of ...
Margit Mutso, Andrei Nikonov, Arno Pihlak, Eva Žusinaite, Liane Viru, Anastasia Selyutina, Tõnu Reintamm, Merike Kelve, Mart Saarma, Mati Karelson, Andres Merits   +10 more
doaj   +1 more source

RNA silencing and HIV: A hypothesis for the etiology of the severe combined immunodeficiency induced by the virus

Retrovirology, 2008
A novel intrinsic HIV-1 antisense gene was previously described with RNA initiating from the region of an HIV-1 antisense initiator promoter element (HIVaINR). The antisense RNA is exactly complementary to HIV-1 sense RNA and capable of forming ~400 base-
Ludwig Linda B
doaj   +1 more source

RNA modifications can affect RNase H1-mediated PS-ASO activity

Molecular Therapy: Nucleic Acids, 2022
Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1.
Katelyn A. Doxtader Lacy, Xue-hai Liang, Lingdi Zhang, Stanley T. Crooke   +3 more
doaj   +1 more source

Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues [PDF]

, 2009
Background: More than 20% of human transcripts have naturally occurring antisense products (or natural antisense transcripts – NATs), some of which may play a key role in a range of human diseases.
Oliver, G.R., Kendrick, H., Jat, P., Oliver, Gavin, Neville, A.M., Gavin R Oliver, Howard Kendrick, Tanney, Austin, Tanney, A., Grigoriadis, A., Grigoriadis, Anita, Smalley, M.J., Austin Tanney, Anita Grigoriadis, Kendrick, Howard, Jat, Parmjit, Matt J Smalley, A Munro Neville, Neville, A. Munro, Parmjit Jat, Smalley, Matthew John   +20 more
core   +1 more source

Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population

Tumor Biology, 2017
There is an increasing body of evidence which highlights the critical functions of long non-coding RNAs in the carcinogenicity mechanism of a variety of cancers.
Shekoufeh Hassanzarei, Mohammad Hashemi, Hedieh Sattarifard, Seyed Mehdi Hashemi, Gholamreza Bahari, Saeid Ghavami   +5 more
doaj   +1 more source

Production of Bulk Amounts of Universal RNA for DNA Microarrays

BioTechniques, 2002
In DNA microarray technology, repeatability and reliability are very important to compare multiple RNA samples from different experiments. The application of common or universal RNA as a standard control equalizes the differences in hybridization ...
L.G. Puskás, Á. Zvara, L. Hackler, T. Micsik, P. van Hummelen   +4 more
doaj   +1 more source

Formation of an RNA Quadruplex-Duplex Hybrid in Living Cells between mRNA of the Epidermal Growth Factor Receptor (EGFR) and a G-Rich Antisense Oligoribonucleotide

Cells, 2020
Antisense DNA oligonucleotides, short interfering RNAs (siRNAs), and CRISPR/Cas9 genetic tools are the most useful therapeutic nucleic acids regulating gene expression based on the antisense specificity towards messenger RNA.
Dorota Gudanis, Damian Kaniowski, Katarzyna Kulik, Daniel Baranowski, Zofia Gdaniec, Barbara Nawrot   +5 more
doaj   +1 more source

Strand-specific RNA-seq reveals ordered patterns of sense and antisense transcription in Bacillus anthracis. [PDF]

PLoS ONE, 2012
BACKGROUND: Although genome-wide transcriptional analysis has been used for many years to study bacterial gene expression, many aspects of the bacterial transcriptome remain undefined.
Karla D Passalacqua, Anjana Varadarajan, Charlotte Weist, Brian D Ondov, Benjamin Byrd, Timothy D Read, Nicholas H Bergman   +6 more
doaj   +1 more source