Results 41 to 50 of about 2,242,574 (332)
Cells, 2020 Antisense DNA oligonucleotides, short interfering RNAs (siRNAs), and CRISPR/Cas9 genetic tools are the most useful therapeutic nucleic acids regulating gene expression based on the antisense specificity towards messenger RNA.
Dorota Gudanis +5 more
doaj +1 more source
Transcriptional interference by antisense RNA is required for circadian clock function
Nature, 2014 Eukaryotic circadian oscillators consist of negative feedback loops that generate endogenous rhythmicities. Natural antisense RNAs are found in a wide range of eukaryotic organisms.
Zhihong Xue +8 more
semanticscholar +1 more source
Antisense ribosomes: rRNA as a vehicle for antisense RNAs. [PDF]
Proceedings of the National Academy of Sciences, 1996 Although rRNA has a conserved core structure, its size varies by more than 2000 bases between eubacteria and vertebrates, mostly due to the size variation of discrete variable regions. Previous studies have shown that insertion of foreign sequences into some of these variable regions has little effect on rRNA function.
R, Sweeney, Q, Fan, M C, Yao
openaire +2 more sources
Strand-specific RNA-seq reveals ordered patterns of sense and antisense transcription in Bacillus anthracis. [PDF]
PLoS ONE, 2012 BACKGROUND: Although genome-wide transcriptional analysis has been used for many years to study bacterial gene expression, many aspects of the bacterial transcriptome remain undefined.
Karla D Passalacqua +6 more
doaj +1 more source
Acta Neuropathologica, 2013 An expanded GGGGCC repeat in a non-coding region of the C9orf72 gene is a common cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis.
S. Mizielinska +6 more
semanticscholar +1 more source
An efficient and rapid method to detect and verify natural antisense transcripts of animal genes
Journal of Integrative Agriculture, 2016 High-throughput sequencing has identified a large number of sense-antisense transcriptional pairs, which indicates that these genes were transcribed from both directions.
Li ZHANG +10 more
doaj +1 more source
Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. [PDF]
PLoS Genetics, 2008 Small RNAs targeted to gene promoters in human cells have been shown to modulate both transcriptional gene suppression and activation. However, the mechanism involved in transcriptional activation has remained poorly defined, and an endogenous RNA ...
Kevin V Morris +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
A Tandem Oligonucleotide Approach for SNP-Selective RNA Degradation Using Modified Antisense Oligonucleotides. [PDF]
PLoS ONE, 2015 Antisense oligonucleotides have been studied for many years as a tool for gene silencing. One of the most difficult cases of selective RNA silencing involves the alleles of single nucleotide polymorphisms, in which the allele sequence is differentiated ...
Dorota Magner +4 more
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source