Results 31 to 40 of about 2,242,574 (332)

Identification and Characterization of a Cis Antisense RNA of the rpoH Gene of Salmonella enterica Serovar Typhi

Frontiers in Microbiology, 2018
Antisense RNAs from complementary strands of protein coding genes regulate the expression of genes involved in many cellular processes. Using deep sequencing analysis of the Salmonella enterica serovar Typhi (S.
Changyan Xiong, Changyan Xiong, Xuejiao Li, Xuejiao Li, Juanli Liu, Xin Zhao, Shungao Xu, Xinxiang Huang   +7 more
doaj   +1 more source

RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications. [PDF]

PLoS ONE, 2015
The inhibitory potency of an antisense oligonucleotide depends critically on its design and the accessibility of its target site. Here, we used an RNA interference-guided approach to select antisense oligonucleotide target sites in the coding region of ...
Margit Mutso, Andrei Nikonov, Arno Pihlak, Eva Žusinaite, Liane Viru, Anastasia Selyutina, Tõnu Reintamm, Merike Kelve, Mart Saarma, Mati Karelson, Andres Merits   +10 more
doaj   +1 more source

Mitochondrial delivery of antisense RNA by MITO-Porter results in mitochondrial RNA knockdown, and has a functional impact on mitochondria.

Biomaterials, 2015
Mitochondrial genome-targeting nucleic acids are promising therapeutic candidates for treating mitochondrial diseases. To date, a number of systems for delivering genetic information to the cytosol and the nucleus have been reported, and several ...
R. Furukawa, Yuma Yamada, E. Kawamura, H. Harashima   +3 more
semanticscholar   +1 more source

RNA silencing and HIV: A hypothesis for the etiology of the severe combined immunodeficiency induced by the virus

Retrovirology, 2008
A novel intrinsic HIV-1 antisense gene was previously described with RNA initiating from the region of an HIV-1 antisense initiator promoter element (HIVaINR). The antisense RNA is exactly complementary to HIV-1 sense RNA and capable of forming ~400 base-
Ludwig Linda B
doaj   +1 more source

RNA modifications can affect RNase H1-mediated PS-ASO activity

Molecular Therapy: Nucleic Acids, 2022
Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1.
Katelyn A. Doxtader Lacy, Xue-hai Liang, Lingdi Zhang, Stanley T. Crooke   +3 more
doaj   +1 more source

Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

Acta Neuropathologica, 2015
GGGGCC repeat expansions of C9ORF72 represent the most common genetic variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We and others have proposed that RNA transcribed from the repeat sequence is toxic via sequestration of RNA ...
J. Cooper-Knock, A. Higginbottom, Matthew J. Stopford, J. R. Highley, P. Ince, S. B. Wharton, S. Pickering-Brown, J. Kirby, G. Hautbergue, Pamela J. Shaw   +9 more
semanticscholar   +1 more source

Heat shock factor HSFB2a involved in gametophyte development of Arabidopsis thaliana and its expression is controlled by a heat-inducible long non-coding antisense RNA

Plant Molecular Biology, 2014
Heat stress transcription factors (HSFs) are central regulators of the heat stress response. Plant HSFs of subgroup B lack a conserved sequence motif present in the transcriptional activation domain of class A-HSFs.
M. Wunderlich, Rita Gross-Hardt, F. Schöffl   +2 more
semanticscholar   +1 more source

Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues [PDF]

, 2009
Background: More than 20% of human transcripts have naturally occurring antisense products (or natural antisense transcripts – NATs), some of which may play a key role in a range of human diseases.
Oliver, G.R., Kendrick, H., Jat, P., Oliver, Gavin, Neville, A.M., Gavin R Oliver, Howard Kendrick, Tanney, Austin, Tanney, A., Grigoriadis, A., Grigoriadis, Anita, Smalley, M.J., Austin Tanney, Anita Grigoriadis, Kendrick, Howard, Jat, Parmjit, Matt J Smalley, A Munro Neville, Neville, A. Munro, Parmjit Jat, Smalley, Matthew John   +20 more
core   +1 more source

Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population

Tumor Biology, 2017
There is an increasing body of evidence which highlights the critical functions of long non-coding RNAs in the carcinogenicity mechanism of a variety of cancers.
Shekoufeh Hassanzarei, Mohammad Hashemi, Hedieh Sattarifard, Seyed Mehdi Hashemi, Gholamreza Bahari, Saeid Ghavami   +5 more
doaj   +1 more source

Production of Bulk Amounts of Universal RNA for DNA Microarrays

BioTechniques, 2002
In DNA microarray technology, repeatability and reliability are very important to compare multiple RNA samples from different experiments. The application of common or universal RNA as a standard control equalizes the differences in hybridization ...
L.G. Puskás, Á. Zvara, L. Hackler, T. Micsik, P. van Hummelen   +4 more
doaj   +1 more source