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Rituximab in the treatment of progressive interstitial lung disease associated with the antisynthetase syndrome. [PDF]
Arthritis Res TherNarváez J +8 more
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Joint Bone Spine, 2003
Seven autoantibodies directed against synthetases have been identified to date, the best known being anti-Jo1. Synthetases play a vital role in protein synthesis by catalyzing the acetylation of transfer RNAs (tRNAs). The most common form of antisynthetase syndrome is characterized by anti-Jo1 production, interstitial lung disease (ILD), inflammatory ...
Mohamed Hamidou
exaly +3 more sources
Seven autoantibodies directed against synthetases have been identified to date, the best known being anti-Jo1. Synthetases play a vital role in protein synthesis by catalyzing the acetylation of transfer RNAs (tRNAs). The most common form of antisynthetase syndrome is characterized by anti-Jo1 production, interstitial lung disease (ILD), inflammatory ...
Mohamed Hamidou
exaly +3 more sources
Clinical manifestations and treatment of antisynthetase syndrome
Best Practice and Research in Clinical Rheumatology, 2020Antisynthetase syndrome (ASyS) is an autoimmune disease clinically manifested most often by interstitial lung disease, myositis, and arthritis. Raynaud's syndrome, fever, and rashes are also commonly seen. This syndrome is characterized by the highly specific presence of antibodies against various aminoacyl transfer RNA synthetases, including Jo-1 and ...
Joanna L, Marco, Bridget F, Collins
exaly +3 more sources
Anti-Ro52 antibodies, antisynthetase antibodies, and antisynthetase syndrome
Clinical Rheumatology, 2007 We present a case of antisynthetase syndrome manifesting with interstitial lung disease, mechanic's hands, nailfold abnormalities, and subclinical myositis, in the presence of antibodies to the aminoacyl tRNA synthetase PL-12 and also to Ro52. Antibodies to Ro52 have been recently associated with idiopathic inflammatory myositis, but there have only ...
Limaye, V. +4 more
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Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course [PDF]
Journal of Clinical Medicine, 2019 Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed ...
Lorenzo Cavagna +2 more
exaly +6 more sources
Efficacy of rituximab in refractory antisynthetase syndrome
Internal Medicine Journal, 2012 We report the successful use of repeated administration of rituximab in a patient with antisynthetase syndrome refractory to conventional immunosuppressive medications.
V Limaye, P Hissaria
exaly +2 more sources
Current Rheumatology Reports, 2011
Autoantibodies to eight of the aminoacyl-transfer RNA synthetases-the most well-recognized of which is anti-histidyl (Jo-1)-have all been implicated in the pathogenesis of antisynthetase syndrome (AS). AS is characterized by varying degrees of interstitial lung disease, myositis, arthropathy, fever, Raynaud's phenomenon, and mechanic's hands, and the ...
Elena, Katzap +2 more
openaire +2 more sources
Autoantibodies to eight of the aminoacyl-transfer RNA synthetases-the most well-recognized of which is anti-histidyl (Jo-1)-have all been implicated in the pathogenesis of antisynthetase syndrome (AS). AS is characterized by varying degrees of interstitial lung disease, myositis, arthropathy, fever, Raynaud's phenomenon, and mechanic's hands, and the ...
Elena, Katzap +2 more
openaire +2 more sources