ABSTRACT CYP3A5 genotype is a known predictor of tacrolimus dose requirements. This single‐center retrospective study evaluated the impact of CYP3A5 genotype‐guided dosing, implemented at our institution in 10/2023, on early tacrolimus exposure. Patients were included if they were adult kidney transplant recipients between 7/2014 and 10/2024; patients ...
Amy L. Pasternak +6 more
wiley +1 more source
A Review of Induction with Rabbit Antithymocyte Globulin in Pediatric Heart Transplant Recipients
Pediatric heart transplantation (pHTx) represents only a small proportion of cardiac transplants. Due to these low numbers, clinical data relating to induction therapy in this special population are far less extensive than for adults.
Boeken, Udo +34 more
core +1 more source
BACKGROUND Induction immunosuppression reduces early rejection after solid organ transplantation but may increase long-term malignancy risk, including keratinocyte carcinoma.
Mary Rojas +4 more
core +1 more source
An Epstein-Barr Virus-Associated Leukemic Lymphoma in a Patient Treated with Rabbit Antithymocyte Globulin and Cyclosporine for Hepatitis-Associated Aplastic Anemia [PDF]
Lymphoproliferative disorders (LPDs) are generally caused by uncontrolled B-cell proliferation induced by the Epstein-Barr virus (EBV) in the setting of impaired EBV-specific T-cell immunity, particularly when there is pharmacological immunosuppression ...
22745 +16 more
core +1 more source
Antithymocyte immunoglobulins remain to be one of the most effective immunosuppressants used in transplantology and in the treatment of autoimmune diseases. The unique features of the mechanisms of individual antithymocyte globulin preparations should be
A D Kulagin +3 more
doaj
Unrelated donor hematopoietic stem cell transplantation for patients with hematologic malignancies using a nonmyeloablative conditioning regimen of fludarabine, low-dose total body irradiation, and rabbit antithymocyte globulin [PDF]
Hematopoietic stem cell chimerism can be established after low-dose conditioning regimens, although the risk of donor cell rejection increases for unrelated donor transplantations. We added pretransplantation rabbit antithymocyte globulin (6 mg/kg) to an
Brecher, Barbara Adler +8 more
core +1 more source
Cyclophosphamide and antithymocyte globulin to condition patients with aplastic anemia for allogeneic marrow transplantations: The experience in four centers [PDF]
This report summarizes the experience with a conditioning regimen of cyclophosphamide and antithymocyte globulin in patients with severe aplastic anemia given HLA-matched related marrow grafts at 4 transplantation centers.
Sanders, Jean +11 more
core +1 more source
Acute graft-versus-host disease in thalassaemic marrow transplantation with low-dose antithymocyte globulin [PDF]
465-469Our unit performed transplantations on 21 classes II and III thalassaemic patients [class II patients had either hepatomegaly or portal fibrosis and class III patients had both]. We used busulfan [15 mg/kg] and cyclophosphamide [200 mg/kg].
Khojasteh, H.N.
core +1 more source
Severe aplastic anemia (SAA) is a serious bone marrow disease that needs a comprehensive and service-intense treatment with either bone marrow transplantation (BMT) or immunosuppressive therapy (IST); both are difficult to optimally offer in resources ...
Ankit B Patel +5 more
doaj +1 more source
CHALLENGES IN TREATMENT OF RENAL GRAFT ACUTE ANTIBODY-MEDIATED REJECTION
Diagnostic criteria and treatment protocols for acute antibody-mediated rejection (AMR) of kidney allograft remain controversial. We report the case of early severe AMR after primary kidney transplantation. The graft removal was considered in the absence
A. I. Sushkov, A. V. Sharshatkin
doaj +1 more source

