Results 181 to 190 of about 59,908 (306)

Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins. [PDF]

open access: yes, 2019
Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality.
Cobb, Ronald R   +12 more
core  

The enemy at the gate: Botulism

open access: yesTurkish Journal of Emergency Medicine
Botulism, caused by Clostridium botulinum, continues to pose a significant threat to public health. This review explores the historical context and contemporary relevance of botulism, emphasizing its potential lethality and evolving medical applications.
Ömer Taşkın   +1 more
doaj   +1 more source

Druggability of bacterial toxins-antitoxins [PDF]

open access: yes, 2015
53 p.-8 fig.-3 tab.Type II (proteic) toxin-antitoxin (TA) operons are widely spread in bacteria and archaea. They are organized as operons in which, usually, the antitoxin gene precedes the cognate toxin gene.
Balsa, Dolors   +2 more
core  

Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology.

open access: yesMolecules and Cells, 2018
Alexander Harms   +3 more
semanticscholar   +1 more source

Novel Single-Cell Method for Studying Toxin-Antitoxin Systems [PDF]

open access: yes, 2016
细菌的抗药性危害日益严重,毒素-抗毒素(TA)系统在细菌内的异质性表达是多药耐受性存留细胞形成的重要原因。阐明致病菌中毒素-抗毒素系统的作用机理和生理功能对研发防控致病菌的新策略和疾病诊断治疗等具有重要意义。目前,对TA系统的研究主要集中在基因水平或转录水平,而传统基于蛋白质水平的检测方法,如WesternBlot等都是对大量细菌裂解液中的毒素抗毒素蛋白进行检测,是大量细菌内毒素抗毒素蛋白表现的集权平均。对单细菌水平的毒素-抗毒素蛋白进行快速逐一分析可揭示因集权平均而被掩盖的个体差异 ...
宋毅怡
core  

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