Results 161 to 170 of about 447,103 (266)

Severe Immune-Related Adverse Events Associated with Durable Antitumor Responses Following Immune Checkpoint Inhibitor Therapy: Two Case Reports. [PDF]

Cancer Manag Res
Chen Q, Lin X, Chen L, Yao J, Yan Y, Zhang X, Yang D, Lin X, Chen S, Chen X, Yu N.   +10 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Expert consensus on prevention and management of nausea and vomiting associated with CLDN18.2-targeted therapeutic drugs (2026 edition)

Zhongguo aizheng zazhi
Claudin 18.2 (CLDN18.2) has emerged as an important therapeutic target in gastrointestinal malignancies, particularly gastric cancer, adenocarcinoma of gastroesophageal junction, and pancreatic cancer.
Antitumor Drug Safety Management Professional Committee of Shanghai Anti-Cancer Association
doaj  

The dual immune landscape of homologous recombination-deficient tumors: mechanisms and therapeutic implications. [PDF]

Cancer Metastasis Rev
Yang Y, Yin Y, Rong S, Qian Y, Li D, Zhang Y, Wang X.   +6 more
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli

, 2017
Sarra Setrerrahmane,1 Jian Yu,1 Jingchao Hao,1,2 Heng Zheng,3 Hanmei Xu1,3 1The Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical University, Nanjing, Jiangsu, 2College of Pharmacy & the Provincial Key ...
Setrerrahmane S, Zheng H, Hao J, Yu J, Xu H   +4 more
core  

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies. [PDF]

Adv Sci (Weinh)
Xiang G, Zhou Z, Jiang X, Du Z, Zhan Y, Liu X.   +5 more
europepmc   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Editorial: Extreme environmental microbial products: Structures, functions, biosynthesis

Frontiers in Microbiology, 2023
Junfeng Wang, Xianwen Yang, Li Liao, Martina Cappelletti, Mirko Basen   +4 more
doaj   +1 more source

Decoding the tumor microenvironment of triple-negative breast cancer: from immune evasion to precision immunotherapy. [PDF]

Front Immunol
Cao H, Tao M, Qin X, Guo H.
europepmc   +1 more source