Results 41 to 50 of about 112,335 (304)

Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties

Evidence-Based Complementary and Alternative Medicine, 2018
Echinoderms are a renewable resource with an economic value due to their increasing demand as food and/or source of bioactive molecules exerting antitumor, antiviral, anticoagulant, antioxidant, and antimicrobial activities.
L. Stabili, M. Acquaviva, R. A. Cavallo, C. Gerardi, M. Narracci, P. Pagliara   +5 more
semanticscholar   +1 more source

On the discovery of a potential survivin inhibitor combining computational tools and cytotoxicity studies

Heliyon, 2019
Survivin protein is a metalloprotein member of the inhibitors of apoptosis proteins family, involved in the regulation of programmed cell death. Due to the recent development of antitumor therapies having survivin as molecular target, several strategies ...
Patricia A. Quispe, Martin J. Lavecchia, Ignacio E. León   +2 more
doaj   +1 more source

Protective effect of aqueous extract of Pleurotus eous against Dalton's lymphoma ascites tumor in mice

Journal of Agriculture and Food Research, 2023
The antitumor efficacy of Pleurotus eous aqueous extract (PEAE) was investigated both in vitro and in vivo. The MTT test was used to determine in vitro cytotoxicity against the Dalton's Lymphoma Ascites (DLA) cell line.
Vadivukkarasi Sasikumar, Sudha Govindan, Gayathri Rajendran, Archana Rajendran, Prasanna Ramani, Mirian Pateiro, José M. Lorenzo   +6 more
doaj   +1 more source

Small molecule induced reactivation of mutant p53 in cancer cells [PDF]

, 2013
The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams, Alan R. Fersht, Andreas C. Joerger, Boeckler, Brown, Bullock, Bullock, Chipuk, Chuckowree, Cook, Dearth, Di Como, Emsley, Endo, Foster, Gannon, Green, Hengartner, Irina S. Chuckowree, Jahangir Amin, Joerger, Joerger, Joerger, Joerger, John Spencer, Johnson, Kaar, Kabsch, Kojima, Kojima, Lambert, Lane, Legros, Leslie, Liu, Newhouse, Oda, Petitjean, Rainer Wilcken, Rippin, Speidel, Spencer, Spencer, Spencer, Spencer, Spencer, Taylor, Van Maerken, Vassilev, Villunger, Vousden, Walerych, Wang, Wattel, Wilcken, Wilcken, Wolter, Xiangrui Liu, Yu   +58 more
core   +2 more sources

Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo

PLoS ONE, 2023
Metastatic colorectal cancer (mCRC) is the second leading cause of cancer deaths in the United States. More than 50% of patients with mCRC harbor mutations of the oncogenic driver RAS (KRAS or NRAS).
Fan Fan, Susmita Ghosh, Reid Powell, Jason Roszik, Yongsun Park, Mary Sobieski, Alexey Sorokin, Clifford Stephan, Scott Kopetz, Lee M. Ellis, Rajat Bhattacharya   +10 more
doaj   +3 more sources

Uso de teste de químio-sensibilidade para escolha da quimioterapia adjuvante no câncer gástrico avançado

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Introduzir e familiarizar em nosso meio o uso do teste de químio-sensibilidade MTT avaliando a ação de agentes quimioterápicos sobre células tumorais de 30 doentes com câncer gástrico avançado.
Wilson Shinjiro Matsuzaki, Francisco César Martins Rodrigues, Carlos Alberto Malheiros, Fares Rahal   +3 more
doaj   +1 more source

Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling

eLife, 2022
The transcription factor TEAD, together with its coactivator YAP/TAZ, is a key transcriptional modulator of the Hippo pathway. Activation of TEAD transcription by YAP has been implicated in a number of malignancies, and this complex represents a ...
Mengyang Fan, Wenchao Lu, Jianwei Che, Nicholas P Kwiatkowski, Yang Gao, Hyuk-Soo Seo, Scott B Ficarro, Prafulla C Gokhale, Yao Liu, Ezekiel A Geffken, Jimit Lakhani, Kijun Song, Miljan Kuljanin, Wenzhi Ji, Jie Jiang, Zhixiang He, Jason Tse, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Joseph D Mancias, Jarrod A Marto, Sirano Dhe-Paganon, Tinghu Zhang, Nathanael S Gray   +25 more
doaj   +1 more source

High-throughput approaches to discover novel immunomodulatory agents for cancer [PDF]

, 2013
The clinical success of immunomodulatory thalidomide derivatives has renewed the general interest in immunomodulatory anticancer compounds and prompted us to develop a high-throughput system to quantify immune effector-cell activity.
McMillin, Douglas William, Mitsiades, Constantine S   +1 more
core   +1 more source

Assessing individual head and neck squamous cell carcinoma patient response to therapy through integration of functional and genomic data

Scientific Reports
Even though head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide, there are only two PD-1 targeted immunotherapies (pembrolizumab and nivolumab) and one tumor intrinsic EGFR targeted therapy (cetuximab) that are FDA ...
Daniel Bottomly, Chase Mathieson, Myles Vigoda, Sophia Jeng, Nathaniel Evans, Ashley Anderson, Aurora Blucher, Aletha Lesch, Christina Zheng, Ted Laderas, James Jacobs, Molly Kulesz-Martin, Shannon McWeeney   +12 more
doaj   +1 more source

Novel cyanine dye as competitive ligand for probing the drug–nucleic acid interactions

Біофізичний вісник, 2020
Background: During the past decades, increasing attention has been given to elucidating the molecular details of interactions between the pharmacological agents and nucleic acids since the drug–DNA complexation may lead to impairment of DNA replication ...
O. Zhytniakivska, U. Tarabara, A. Kurutos, A. Zabrudska, K. Vus, V. Trusova, G. Gorbenko, T. Deligeorgiev   +7 more
doaj   +1 more source