Results 1 to 10 of about 491,510 (368)

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Molecular Cancer, 2020
Background Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond to first-generation EGFR inhibitors; however, the efficacy of these drugs is limited by acquired resistance driven by the EGFR T790M mutation.
Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun, Yi Chen, Meiyu Geng, Ke Ding, Jian Ding, Hua Xie   +20 more
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ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK

Frontiers in Pharmacology, 2022
Hyperactivation of Bruton’s tyrosine kinase (BTK) or interleukin-2-inducible T cell kinase (ITK) has been attributed to the pathogenesis of B-cell lymphoma or T-cell leukemia, respectively, which suggests that Bruton’s tyrosine kinase and interleukin-2 ...
Peiran Song, Peiran Song, Gang Bai, Shingpan Chan, Tao Zhang, Linjiang Tong, Yi Su, Yanyan Shen, Yi Chen, Yingqiang Liu, Mengzhen Lai, Mengzhen Lai, Yi Ning, Haotian Tang, Yan Fang, Yi Chen, Ke Ding, Jian Ding, Jian Ding, Hua Xie, Hua Xie, Hua Xie   +21 more
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A Review: Pharmacological Effect of Natural Compounds in Diospyros kaki Leaves from the Perspective of Oxidative Stress

Molecules, 2023
Oxidative stress is caused by an imbalance between reactive oxygen species and antioxidant levels. Current research suggests that oxidative stress is one of the key factors in the development of many chronic diseases, and it has been a concern for many ...
Chong Hong, Xu Wang, Jianjian Xu, Jianxing Guo, Houlin Peng, Yan Zhang   +5 more
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CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3

Cell Death and Disease, 2023
CMTR1, also called IFN-stimulated gene 95 kDa protein (ISG95), is elevated by viral infection in a variety of cells. However, the functions of CMTR1 in colorectal cancer (CRC), especially its roles in tumorigenesis and immune regulation, remain unclear ...
A-bin You, Hu Yang, Chun-ping Lai, Wen Lei, Lu Yang, Jia-lin Lin, Shun-cui Liu, Nan Ding, Feng Ye   +8 more
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Genomic profiling of WRKY transcription factors and functional analysis of CcWRKY7, CcWRKY29, and CcWRKY32 related to protoberberine alkaloids biosynthesis in Coptis chinensis Franch

Frontiers in Genetics, 2023
Coptis chinensis Franch. (Huanglian in Chinese) is an important economic crop with medicinal value. Its rhizome has been used as a traditional herbal medicine for thousands of years in Asia.
Xiaoqiang Huang, An Jia, Tao Huang, Li Wang, Guohua Yang, Wanli Zhao, Wanli Zhao   +6 more
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Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models

Frontiers in Oncology, 2018
Patient-derived xenograft (PDX) models have recently emerged as a highly desirable platform in oncology and are expected to substantially broaden the way in vivo studies are designed and executed and to reshape drug discovery programs.
Marissa Mattar, Craig R. McCarthy, Amanda R. Kulick, Besnik Qeriqi, Sean Guzman, Elisa de Stanchina   +5 more
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Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway

Acta Biochimica et Biophysica Sinica, 2022
Primary hepatic carcinoma is a common malignant tumor. The classic molecular targeted drug sorafenib is costly and is only effective for some patients.
Zhang Yonghui, Zhang Haoyang, Mu Jinage, Han Meiyue, Cao Zhihao, Dong Feng, Wang Tingting, Pan Lian, Luo Wujing, Li Jiaxin, Liu Huan, Jin Lishan, Ding Wenxuan, Wei Yong, Deng Xuesong, Liu Dan, He Xiuzhen, Pang Yi, Mu Xiao, Wu Zhongjun, Chen Dilong   +20 more
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Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis

Biology Direct, 2021
Background Recently, overwhelming evidence supports that long noncoding RNAs (lncRNAs) play crucial roles in the occurrence and progression of tumors. However, the role and mechanism of lncRNA TFAP2A-AS1 in human gastric cancer (GC) remains unclear. Thus,
Xin Zhao, Linlin Chen, Jingxun Wu, Jun You, Qingqi Hong, Feng Ye   +5 more
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Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma

Acta Pharmaceutica Sinica B, 2023
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults and is poorly controlled. Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression, and co-targeting of CSF1R and ...
Yingqiang Liu, Zhengsheng Zhan, Zhuang Kang, Mengyuan Li, Yongcong Lv, Shenglan Li, Linjiang Tong, Fang Feng, Yan Li, Mengge Zhang, Yaping Xue, Yi Chen, Tao Zhang, Peiran Song, Yi Su, Yanyan Shen, Yiming Sun, Xinying Yang, Yi Chen, Shanyan Yao, Hanyu Yang, Caixia Wang, Meiyu Geng, Wenbin Li, Wenhu Duan, Hua Xie, Jian Ding   +26 more
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SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer

Signal Transduction and Targeted Therapy, 2023
Genomic MET amplification and exon 14 skipping are currently clinically recognized biomarkers for stratifying subsets of non-small cell lung cancer (NSCLC) patients according to the predicted response to c-Met inhibitors (c-Metis), yet the overall ...
Ji Zhou, Xu-Chao Zhang, Shan Xue, Mengdi Dai, Yueliang Wang, Xia Peng, Jianjiao Chen, Xinyi Wang, Yanyan Shen, Hui Qin, Bi Chen, Yu Zheng, Xiwen Gao, Zuoquan Xie, Jian Ding, Handong Jiang, Yi-Long Wu, Meiyu Geng, Jing Ai   +18 more
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