New Antitumor Organotitanium Complexes with a Pendant Biologically Active Diazo Group [PDF]
, 2022 The ligand of antitumor organotitanium or other metallodug complexes plays a pivotal role in determining the mechanism of their cytotoxic action. Although the specific contribution of several ligands is generally well established, our understanding of ...
Gregory, Arzoumanidis
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Antitumor factors of draining lymph node cells of the mouse sensitized with ehrlich ascites tumor cells. I. Antitumor effect of subcellular factor [PDF]
, 1969 The regional lymph node cells of the mice sensitized with Ehrlich ascites tumor cells is known to possess a substance that shows antitumor activity on target cells (JTC-II cells). For the purpose to clarify the localization of this substance the regional
Nakashima, Youichi
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Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticles [PDF]
, 2015 The use of doxorubicin (DOX), one of the most effective antitumor molecules in the treatment of metastatic breast cancer, is limited by its low tumor selectivity and its severe side effects.
Entrena Fernández, José Manuel +14 more
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Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents [PDF]
, 2010 Etilni ester 2-amino-5-acetil-4-metil-tiofen-3-karboksilne kiseline (1) i 5-acetil-2-amino-4-metiltiofen-3-karbohidrazid (2) sintetizirani su i upotrebljeni kao reaktanti u sintezi novih spojeva 1-(5-amino-4-(3,5-dimetil-1H-pirazol-1-karbonil)-3 ...
Farid Badria +8 more
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A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR [PDF]
, 2012 The imidazotetrazine ring is an acid-stable precursor and prodrug of highly-reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The
Hartley, J.A. +23 more
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Red-light-activatable "AND gated" antitumor immunosuppressant [PDF]
, 2023 Immunosuppressants are emerging as promising candidates for cancer therapy with lower cytotoxicity compared to traditional chemotherapy drugs; yet, the intrinsic side effects such as immunosuppression remain a critical concern.
Simin, Xia +3 more
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Disporum nanchuanense (Colchicaceae), a new species from Chongqing, China [PDF]
PhytoKeys, 2019 Disporum nanchuanense (Colchicaceae), a new species from Jinfo Mountain National Nature Reserve, Nanchuan District, Chongqing, China, is described and illustrated. It is similar to D. longistylum and D.
Xinxin Zhu, Shuai Liao, Sirong Yi
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Frontiers in Pharmacology, 2023 Pathological cardiac hypertrophy is an important risk factor for cardiovascular disease. However, drug therapies that can reverse the maladaptive process and restore heart function are limited. Ganoderma lucidum polysaccharides (GLPs) are one of the main
Changlin Zhen +19 more
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Antitumor activity of a novel TLR9 agonist and cooperativity with targeted agents [PDF]
, 2008 Novel modified Toll-like receptor 9 (TLR9) agonists, termed immune modulatory oligonucleotides (IMOs), exhibit antitumor activity and are currently investigated in cancer patients. Intriguingly, their mechanisms of action on tumor growth and angiogenesis
Garofalo, Sonia
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Interactions of DNA with a new Platinum(IV) Azide Dipyridine complex activated by UVA and visible light : relationship to toxicity in tumor cells [PDF]
, 2012 The Pt IV diazido complex trans,trans,trans-[Pt(N 3) 2(OH) 2(pyridine) 2] (1) is unreactive in the dark but is cytotoxic when photoactivated by UVA and visible light.
Sadler, P. J. +15 more
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