New Antitumor Organotitanium Complexes with a Pendant Biologically Active Diazo Group [PDF]
, 2022 The ligand of antitumor organotitanium or other metallodug complexes plays a pivotal role in determining the mechanism of their cytotoxic action. Although the specific contribution of several ligands is generally well established, our understanding of ...
Gregory, Arzoumanidis
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Antitumor Effects of Selenium [PDF]
International Journal of Molecular Sciences, 2021 Functions of selenium are diverse as antioxidant, anti-inflammation, increased immunity, reduced cancer incidence, blocking tumor invasion and metastasis, and further clinical application as treatment with radiation and chemotherapy. These functions of selenium are mostly related to oxidation and reduction mechanisms of selenium metabolites.
Seung Jo Kim +3 more
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Anticellular and Antitumor Activity of Duocarmycins, Novel Antitumor Antibiotics [PDF]
Japanese Journal of Cancer Research, 1992 The anticellular and antitumor activities of novel antitumor antibiotics, duocarmycins (DUMs), were examined against human and murine tumor cells. DUMs consist of live compounds, A, B1, B2, C1, and C2, which possess a pharmacophore similar to that of CC‐1065, a previously isolated antibiotic.
Gomi, Katsushige +9 more
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Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticles [PDF]
, 2015 The use of doxorubicin (DOX), one of the most effective antitumor molecules in the treatment of metastatic breast cancer, is limited by its low tumor selectivity and its severe side effects.
Entrena Fernández, José Manuel +14 more
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Antitumor factors of draining lymph node cells of the mouse sensitized with ehrlich ascites tumor cells. I. Antitumor effect of subcellular factor [PDF]
, 1969 The regional lymph node cells of the mice sensitized with Ehrlich ascites tumor cells is known to possess a substance that shows antitumor activity on target cells (JTC-II cells). For the purpose to clarify the localization of this substance the regional
Nakashima, Youichi
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Tanespimycin as Antitumor Therapy
Clinical Lymphoma Myeloma and Leukemia, 2011 The 90 kDa heat shock protein (HSP90), which facilitates proper folding and stability of numerous signaling molecules involved in growth control, cell survival, and development, has been implicated in malignant processes. Like its parent compound geldanamycin, tanespimycin binds to HSP90 and causes antineoplastic effects in vitro and in vivo.All ...
Dimopoulos, Meletios-Athanassios +3 more
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A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR [PDF]
, 2012 The imidazotetrazine ring is an acid-stable precursor and prodrug of highly-reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The
Hartley, J.A. +23 more
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Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents [PDF]
, 2010 Etilni ester 2-amino-5-acetil-4-metil-tiofen-3-karboksilne kiseline (1) i 5-acetil-2-amino-4-metiltiofen-3-karbohidrazid (2) sintetizirani su i upotrebljeni kao reaktanti u sintezi novih spojeva 1-(5-amino-4-(3,5-dimetil-1H-pirazol-1-karbonil)-3 ...
Farid Badria +8 more
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Red-light-activatable "AND gated" antitumor immunosuppressant [PDF]
, 2023 Immunosuppressants are emerging as promising candidates for cancer therapy with lower cytotoxicity compared to traditional chemotherapy drugs; yet, the intrinsic side effects such as immunosuppression remain a critical concern.
Simin, Xia +3 more
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Disporum nanchuanense (Colchicaceae), a new species from Chongqing, China [PDF]
PhytoKeys, 2019 Disporum nanchuanense (Colchicaceae), a new species from Jinfo Mountain National Nature Reserve, Nanchuan District, Chongqing, China, is described and illustrated. It is similar to D. longistylum and D.
Xinxin Zhu, Shuai Liao, Sirong Yi
doaj +3 more sources