Results 31 to 40 of about 447,103 (266)

RNA-Seq-Based TCR Profiling Reveals Persistently Increased Intratumoral Clonality in Responders to Anti-PD-1 Therapy

Frontiers in Oncology, 2020
Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to immunotherapy.
Ekaterina A. Zhigalova, Anna I. Izosimova, Diana V. Yuzhakova, Lilia N. Volchkova, Irina A. Shagina, Irina A. Shagina, Maria A. Turchaninova, Maria A. Turchaninova, Maria A. Turchaninova, Ekaterina O. Serebrovskaya, Ekaterina O. Serebrovskaya, Ekaterina O. Serebrovskaya, Elena V. Zagaynova, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, George V. Sharonov, George V. Sharonov, George V. Sharonov   +19 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin [PDF]

, 2017
Kazuhisa Kameyama,1,* Keiichi Motoyama,1,* Nao Tanaka,1 Yuki Yamashita,1 Taishi Higashi,1 Hidetoshi Arima1,2,* 1Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, 2Program for Leading Graduate Schools “HIGO (Health ...
Kazuhisa Kameyama, Yamashita Y, Nao Tanaka, Hidetoshi Arima, Motoyama K, Yuki Yamashita, Tanaka N, Taishi Higashi, Higashi T, Arima H, Kameyama K, Keiichi Motoyama   +11 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter [PDF]

SMYD3 (SET and MYND domain-containing 3) is a histone lysine methyltransferase highly expressed in different types of cancer(s) and is a promising epigenetic target for developing novel antitumor therapeutics.
Cai, Jianghong, Lei, Wei, Ding, Qian, Zhan, Yangyang, Bao, Leilei, Zhu, Yi Zhun, Hu, Wei, Rose, Peter, Tang, Zhiyuan, Jin, Li, Song, Wu   +10 more
core   +1 more source

Cytochalasin H enhances sensitivity to gefitinib in non-small-cell lung cancer cells through inhibiting EGFR activation and PD-L1 expression

Scientific Reports
In our previous study, we have isolated cytochalasin H (CyH) from endophytic fungus derived from mangrove plant and found that CyH inhibited the proliferation of non-small cell lung cancer (NSCLC) cells.
Guihong Zhang, Jiao Liu, Sanzhong Li, Tianyu Wang, Li Chen, Huan Li, Qingkai Ding, Xiangyong Li, Shaoping Zhu, Xudong Tang   +9 more
doaj   +1 more source

Synergistic Anticancer Activity of Fucoidan from Lessonia trabeculata Combined with Chemotherapeutic Agents in 4T1 Breast Spheroids

Marine Drugs
Triple-negative breast cancer (TNBC) is known for being aggressive and potentially resistant to chemotherapy. This means that new ways to improve cancer treatments are a priority.
Rosa María Condori Macuri, Libertad Alzamora-Gonzales, Erasmo Honorio Colona-Vallejos, Raisa Teresa Cruz Riquelme, Laura Inés Pecho Chávez, Jherson Oscar Cisneros Gutierrez, Victor Alonso Montejo Anlas   +6 more
doaj   +1 more source

circFIG 4 drives the carcinogenesis and metastasis of esophagus cancer via the miR‐493‐5p/E2F3 axis

Thoracic Cancer, 2022
Background Esophageal cancer (EC) is a highly malignant tumor of the digestive tract. Circular RNAs (circRNAs) have been verified to play a regulatory role in the occurrence and progression of different cancers, including EC.
Zhen Huang, Chunyue Wang, Xin Zhao
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Antitumor activity and biodistribution of cisplatin nanocapsules in nude mice bearing human ovarian carcinoma xenografts [PDF]

, 2008
Cisplatin nanocapsules represent a novel lipid formulation of the anticancer drug cis-diamminedichloridoplatinum(II) (cisplatin), characterized by an unprecedented cisplatin-tolipid molar ratio, and exhibiting strongly increased in-vitro cytotoxicity ...
Biochemie van Membranen, Chemical Biology & Organic Chemistry, Hamelers, I.H., Membraan enzymologie, Erkelens, C.A.M., Erkelens, CA, Boven, E., Hamelers, I.H.L., van der Born, K., de Kroon, A.I.P.M., Peters, G.J., van der Born, K, Staffhorst, R.W.H.M., Staffhorst, R.W., Dep Scheikunde, de Kroon, A.I.   +15 more
core   +1 more source