Results 21 to 30 of about 491,510 (368)

Ganoderma lucidum polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy

Frontiers in Pharmacology, 2023
Pathological cardiac hypertrophy is an important risk factor for cardiovascular disease. However, drug therapies that can reverse the maladaptive process and restore heart function are limited. Ganoderma lucidum polysaccharides (GLPs) are one of the main
Changlin Zhen, Changlin Zhen, Xunxun Wu, Jing Zhang, Jing Zhang, Dan Liu, Dan Liu, Guoli Li, Guoli Li, Yongbo Yan, Xiuzhen He, Xiuzhen He, Jiawei Miao, Jiawei Miao, Hongxia Song, Hongxia Song, Yifan Yan, Yifan Yan, Yonghui Zhang, Yonghui Zhang   +19 more
doaj   +1 more source

Antitumor activity of a new antitumor antibiotic, sporamycin.

Gan, 1977
Sporamycin is an antitumor antibiotic isolated from the culture filtrate of Streptosporangium strain No. PO-357. Hydrolysate of the antibiotic showed at least 12 kinds of amino acid, and the molecular weight was calculated approximately as 8,500 approximately 9,000.
Komiyama, K, Takeshima, H, Umezawa, I
openaire   +2 more sources

Interactions of DNA with a new Platinum(IV) Azide Dipyridine complex activated by UVA and visible light : relationship to toxicity in tumor cells [PDF]

, 2012
The Pt IV diazido complex trans,trans,trans-[Pt(N 3) 2(OH) 2(pyridine) 2] (1) is unreactive in the dark but is cytotoxic when photoactivated by UVA and visible light.
Sadler, P. J., Jitka Pracharova, Pracharova, Jitka, Kasparkova, Jana, Jana Stepankova, Farrer, Nicola J., Brabec, V. (Viktor), Lenka Zerzankova, Nicola J. Farrer, Peter J. Sadler, Jana Kasparkova, Zerzankova, Lenka, Novakova, Olga, Stepankova, Jana, Viktor Brabec, Olga Novakova   +15 more
core   +1 more source

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

Acta Pharmaceutica Sinica B, 2018
The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-ERK signal cascade, functions to transmit upstream signals to its downstream effectors to regulate physiological process such as cell proliferation, differentiation ...
Feifei Liu, Xiaotong Yang, Meiyu Geng, Min Huang   +3 more
doaj   +1 more source

A novel STING agonist with systemic and durable anti‐tumour activity

Clinical and Translational Discovery, 2023
Background Stimulator of interferon genes (STING) has emerged as a crucial and promising target in tumor immunotherapy in recent years. Its agonists play a vital role in activating both innate and adaptive immune responses to combat cancer.
Xiyuan Wang, Ancheng Shen, Yan Zhang, Xiaoxu Chen, Jian Ding, Ao Zhang, Meiyu Geng, Chunyong Ding, Zuoquan Xie   +8 more
doaj   +1 more source

Gilvocarcins,new antitumor antibiotics 3. Antitumor activity.

The Journal of Antibiotics, 1981
Gilvocarcin V, isolated rom a Streptomyces culture showed activity against experimental tumors such as sarcoma 180, Ehrlich carcinoma, Meth 1 fibrosarcoma, MH134 hepatoma and lymphocytic leukemia P388. In particular, 40% of treated mice survived for 60 days, after intraperitoneal administration of gilvocarcin V to mice bearing Ehrlich ascites ...
M, Morimoto, S, Okubo, F, Tomita, H, Marumo   +3 more
openaire   +3 more sources

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

Nature Communications, 2019
Cancer subtypes may have distinct metabolic vulnerabilities that can be exploited for therapeutic interventions. Here, the authors show that in lung cancer, genetic activation of distinct oncogenic receptor tyrosine kinases results in unique metabolic ...
Nan Jin, Aiwei Bi, Xiaojing Lan, Jun Xu, Xiaomin Wang, Yingluo Liu, Ting Wang, Shuai Tang, Hanlin Zeng, Ziqi Chen, Minjia Tan, Jing Ai, Hua Xie, Tao Zhang, Dandan Liu, Ruimin Huang, Yue Song, Elaine Lai-Han Leung, Xiaojun Yao, Jian Ding, Meiyu Geng, Shu-Hai Lin, Min Huang   +22 more
doaj   +1 more source

Interactions between gold nanoparticles with different morphologies and human serum albumin

Frontiers in Chemistry, 2023
Introduction: Three different shapes of gold nanoparticles were synthesized in this experiment. At the same time, studies compared their effects with human serum albumin (HSA).Methods: Gold nanoparticles (AuNPs) with three different morphologies, such as,
Jiahui Dai, Chao Chen, Man Yin, Huixing Li, Wenbo Li, Zhaowei Zhang, Qian Wang, Zhongyu Du, Xiangyu Xu, Yunfei Wang   +9 more
doaj   +1 more source

In vitro antioxidant and protective effects of the extract of Broussonetia papyrifera leaves on imiquimod-induced skin lesions in psoriasis-like mice

Pakistan Journal of Pharmaceutical Sciences
Psoriasis is a chronic inflammatory immune-related skin disease. According to literature reports, the leaves of Broussonetia papyrifera exhibit antioxidant, immune-enhancing and antibacterial effects.
Jia An, Ma Xiao-ying, Huang Xiao-qiang, Liu Shun-he, Wang Xin, Xiang De-quan, Ltd., PR China   +7 more
doaj   +1 more source

Antitumor activity of a new antitumor antibiotic, stubomycin.

The Journal of Antibiotics, 1982
The antitumor activity of a new antibiotic, stubomycin, against various murine tumors was studied. Stubomycin showed antitumor activity against Sarcoma 180, IMC-carcinoma and Meth-A tumor. In particular, all of the mice inoculated i.p. with IMC-carcinoma were cured when they were given nine successive injections of stubomycin.
K, Komiyama, K, Edanami, H, Yamamoto, I, Umezawa   +3 more
openaire   +3 more sources