Results 21 to 30 of about 447,103 (266)

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

Acta Pharmaceutica Sinica B, 2018
The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-ERK signal cascade, functions to transmit upstream signals to its downstream effectors to regulate physiological process such as cell proliferation, differentiation ...
Feifei Liu, Xiaotong Yang, Meiyu Geng, Min Huang   +3 more
doaj   +1 more source

A Novel Fully Human Antitumor ImmunoRNase Targeting ErbB2-Positive Tumors [PDF]

, 2010
A second generation anti-ErbB2 ImmunoRNase, called Erb-hcAb-RNase, was obtained by the fusion of Erb-hcAb, a human compact anti-ErbB2 antibody, with human pancreatic ribonuclease (HP-RNase or RNase 1).
Borriello, Marianna
core   +1 more source

A novel STING agonist with systemic and durable anti‐tumour activity

Clinical and Translational Discovery, 2023
Background Stimulator of interferon genes (STING) has emerged as a crucial and promising target in tumor immunotherapy in recent years. Its agonists play a vital role in activating both innate and adaptive immune responses to combat cancer.
Xiyuan Wang, Ancheng Shen, Yan Zhang, Xiaoxu Chen, Jian Ding, Ao Zhang, Meiyu Geng, Chunyong Ding, Zuoquan Xie   +8 more
doaj   +1 more source

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

Nature Communications, 2019
Cancer subtypes may have distinct metabolic vulnerabilities that can be exploited for therapeutic interventions. Here, the authors show that in lung cancer, genetic activation of distinct oncogenic receptor tyrosine kinases results in unique metabolic ...
Nan Jin, Aiwei Bi, Xiaojing Lan, Jun Xu, Xiaomin Wang, Yingluo Liu, Ting Wang, Shuai Tang, Hanlin Zeng, Ziqi Chen, Minjia Tan, Jing Ai, Hua Xie, Tao Zhang, Dandan Liu, Ruimin Huang, Yue Song, Elaine Lai-Han Leung, Xiaojun Yao, Jian Ding, Meiyu Geng, Shu-Hai Lin, Min Huang   +22 more
doaj   +1 more source

In vitro antioxidant and protective effects of the extract of Broussonetia papyrifera leaves on imiquimod-induced skin lesions in psoriasis-like mice

Pakistan Journal of Pharmaceutical Sciences
Psoriasis is a chronic inflammatory immune-related skin disease. According to literature reports, the leaves of Broussonetia papyrifera exhibit antioxidant, immune-enhancing and antibacterial effects.
Jia An, Ma Xiao-ying, Huang Xiao-qiang, Liu Shun-he, Wang Xin, Xiang De-quan, Ltd., PR China   +7 more
doaj   +1 more source

Daphnegiravone D synergistically inhibits liver cancer in combination with oxaliplatin in vitro and in vivo

Acupuncture and Herbal Medicine
Objective:. Daphnegiravone D (DGD), a prenylated flavonoid from Daphne giraldii Nitsche, a plant whose roots and stem are used in Chinese medicine, exerts an inhibitory effect on liver cancer cells.
Yu-Jue Wang, Jiao-Yang Hou, Xin-Ye Wang, Hong-Fei Chen, Shuang Qiu, Qing-Bo Liu, Xiao-Xiao Huang, Guo-Dong Yao, Shao-Jiang Song   +8 more
doaj   +1 more source

Interactions between gold nanoparticles with different morphologies and human serum albumin

Frontiers in Chemistry, 2023
Introduction: Three different shapes of gold nanoparticles were synthesized in this experiment. At the same time, studies compared their effects with human serum albumin (HSA).Methods: Gold nanoparticles (AuNPs) with three different morphologies, such as,
Jiahui Dai, Chao Chen, Man Yin, Huixing Li, Wenbo Li, Zhaowei Zhang, Qian Wang, Zhongyu Du, Xiangyu Xu, Yunfei Wang   +9 more
doaj   +1 more source

Chemosensitivity of human MCF-7 breast cancer cells to diastereoisomeric diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and specific platinum accumulation [PDF]

, 1992
Cisplatin, raceme-diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinu m(II) sulfate (compound I), meso-diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]-platinum(II) sulfate (compound II), and meso-diaqua[1,2-bis(2,6-dichloro-4- hydroxyphenyl ...
Lux, Franz, Koch, Marion, Schönenberger, Helmut, Hollstein, Michael, Reile, Herta, Bernhardt, Günther   +5 more
core   +1 more source

Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure–Activity Relationships

Frontiers in Oncology, 2021
Steroidal alkaloids contain both steroidal and alkaloid properties in terms of chemical properties and pharmacological activities. Due to outstanding biological activities such as alkaloids and similar pharmacological effects to other steroids, steroidal
Ying Huang, Gen Li, Chong Hong, Xia Zheng, Haiyang Yu, Yan Zhang   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source