Results 141 to 150 of about 1,499,897 (194)
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Journal of Medicinal Chemistry, 2008
We have previously reported antitussive effects of naltrindole (NTI), a typical delta opioid receptor antagonist, in a rat model. The ED50 values of NTI by intraperitoneal and peroral injections were 104 microg/kg and 1840 microg/kg, respectively, comparable to those of codeine.
Hideaki Fujii +2 more
exaly +3 more sources
We have previously reported antitussive effects of naltrindole (NTI), a typical delta opioid receptor antagonist, in a rat model. The ED50 values of NTI by intraperitoneal and peroral injections were 104 microg/kg and 1840 microg/kg, respectively, comparable to those of codeine.
Hideaki Fujii +2 more
exaly +3 more sources
Antitussive agents and their sites of action
Trends in Pharmacological Sciences, 1980Yoshitoshi Kase
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Evaluation of a New Antitussive Agent
New England Journal of Medicine, 1953DEXTRO-3-methoxy-N-methylmorphinan§ hydrobromide (dextromethorphan hydrobromide) is an experimental drug that has shown cough-inhibiting properties in animals, but the degree of this effect in human beings was not known. Therefore, a study was undertaken to determine the antitussive effect of this substance clinically. The merits of another compound of
L J, CASS, W S, FREDERIK
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Objecfive evaluation of antitussive agents
Clinical Pharmacology & Therapeutics, 1965Subjective evaluation of antitussives is unreliable. In the search for an ideal procedure for evaluation, several methods have been developed which use bronchial irritants for artificial cough production in selected subjects. The currently popular citric acid and the acetylcholine methods with healthy volunteers were re‐evaluated and in our hands were ...
H, SEVELIUS, P D, LESTER, J P, COLMORE
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Evaluation of Antitussive Agents in Man
Pulmonary Pharmacology, 1996Methodology to evaluate the efficacy of antitussive drugs rely largely on subjective methods and cough counts. There are few studies in cough due to natural disease especially using objective techniques. This paper presents data from a series of randomized, double blind, placebo controlled clinical trials in cough due to both chronic bronchopulmonary ...
L, Parvez +4 more
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The Use of Noscapine (Narcotine) as an Antitussive Agent
Diseases of the Chest, 1957and similar compounds is based on a phenanthrene nucleus, whereas Noscapine is an isoquinoline derivative (related to papaverine). It is readily absorbed after oral or parenteral administration, disappears rapidly from the blood stream, and only traces appear in the urine. Its fate is unknown.
M S, SEGAL +2 more
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Efficacy and tolerability of glaucine as an antitussive agent
Current Medical Research and Opinion, 1984One hundred and thirty out-patients, affected by acute and chronic cough caused by upper respiratory tract inflammation, took part in two clinical studies aimed at evaluating the efficacy and tolerability of glaucine , a new antitussive agent. The first study involved 90 patients in a double-blind comparative trial of glaucine and codeine: both ...
H, Gastpar, D, Criscuolo, H A, Dieterich
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