Results 1 to 10 of about 22,944 (196)

Codeine and Testosterone Concentration Patterns During Co-Administration of Codeine and Testosterone Undecanoate in Male Wistar Rats. [PDF]

Pharmaceuticals (Basel)
Background: Three widely separated sampling days cannot establish conventional pharmacokinetic parameters. We therefore examined exploratory whole-blood codeine and plasma total-testosterone concentration patterns during co-administration of codeine and ...
Ünalmış M, Karakükçü Ç, Yerer MB, Saraçoğlu HD.   +3 more
europepmc   +2 more sources

Testicular Toxicity Following Chronic Codeine Administration Is via Oxidative DNA Damage and Up-Regulation of NO/TNF-α and Caspase 3 Activities

PLoS ONE, 2020
BackgroundCodeine, a 3-methylmorphine, and other related opioids have been implicated in androgen suppression, although the associated mechanisms remain unclear.AimTherefore, the objective of the current study was to elucidate the in vivo molecular ...
Ayodeji Ajayi, Roland Akhigbe
exaly   +2 more sources

Domestic Abuse of Codeine: A Case Study of Non-Medical Use Leading to Fatal Outcome. [PDF]

Toxics
Codeine, an opioid analgesic present in many over-the-counter (OTC) formulations, is frequently misused through non-medical extraction techniques such as cold water extraction (CWE).
Mrochem K, Pieprzyca E, Skalniak G, Obrzut J, Cieśla J, Chełmecka E, Tomsia M, Skowronek R.   +7 more
europepmc   +2 more sources

L-Arginine abrogates maternal and pre-pubertal codeine exposure-induced impaired spermatogenesis and sperm quality by modulating the levels of mRNA encoding spermatogenic genes

Frontiers in Endocrinology, 2023
IntroductionAlthough, codeine has been demonstrated to lower sperm quality; the effects of maternal and prepubertal codeine exposure on male offspring is yet to be reported.
Roland Eghoghosoa Akhigbe, Roland Eghoghosoa Akhigbe, Oladele A. Afolabi, Ayodeji Folorusho Ajayi   +3 more
doaj   +1 more source

The Severity of Dependence Scale (SDS) for Codeine: Preliminary Investigation of the Psychometric Properties of the SDS in an Online Sample of Codeine Users From the UK

Frontiers in Psychiatry, 2021
Objective: Investigate the psychometric properties of the Severity of Dependence Scale (SDS) for codeine and its association with aberrant codeine related behaviors.Design: A voluntary and uncompensated cross-sectional online survey.Setting: Online ...
Paolo Deluca, Michelle Foley, Jacklyn Dunne, Andreas Kimergård   +3 more
doaj   +1 more source

L-Arginine reverses maternal and pre-pubertal codeine exposure-induced sexual dysfunction via upregulation of androgen receptor gene and NO/cGMP signaling.

PLoS ONE, 2022
BackgroundAlthough codeine has been reported to enhance sexual activity by improving penile reflexes, it has been shown to impair fertility indices. Also, codeine impairs ovarian steroidogenesis and folliculogenesis.
Roland Eghoghosoa Akhigbe, Oladele A Afolabi, Ayodeji F Ajayi   +2 more
doaj   +1 more source

Should Codeine Still be Considered a WHO Essential Medicine?

Journal of Pharmacy & Pharmaceutical Sciences, 2021
Codeine continues to be widely used as an analgesic, antidiarrhoeal and antitussive agent. Its analgesic effect depends on its biotransformation to morphine, a strong opioid.
Boni Singu, Roger K Verbeeck
doaj   +1 more source

In vivo exposure to codeine induces reproductive toxicity: role of HER2 and p53/Bcl-2 signaling pathway

Heliyon, 2020
Several studies have implicated codeine use in the aetiopathogenesis of male infertility. The purpose of this study was to investigate the role of HER2, Ki67, oestrogen and p53/Bcl-2 signaling pathways and the possible outcome of codeine cessation on ...
A.F. Ajayi, R.E. Akhigbe
doaj   +1 more source

Study the Histopathological Effect Associated with Oral Overdose of Opioid Derivatives - on Liver and Kidney Tissue in Male Rats [PDF]

Basrah Journal of Veterinary Research, 2023
The current study aimed to ascertain the impact of acute codeine dose (0.50 and 1 ml/ 250g), on the histolopathological profile of the liver and kidney in male rats.
Yasmeen Mohammed
doaj   +1 more source

Impact of Removing Nonprescription Codeine in Australia: Protocol for a Prospective Cohort Study

JMIR Research Protocols, 2020
BackgroundOn February 1, 2018, Australia rescheduled codeine to a prescription-only medication. Many concerns were associated with this change, including increased financial costs, reduced service accessibility, the potential for poorer pain management ...
McCoy, Jacqui, Nielsen, Suzanne, Bruno, Raimondo   +2 more
doaj   +1 more source