Results 1 to 10 of about 47,580 (219)

L-Arginine abrogates maternal and pre-pubertal codeine exposure-induced impaired spermatogenesis and sperm quality by modulating the levels of mRNA encoding spermatogenic genes

Frontiers in Endocrinology, 2023
IntroductionAlthough, codeine has been demonstrated to lower sperm quality; the effects of maternal and prepubertal codeine exposure on male offspring is yet to be reported.
Roland Eghoghosoa Akhigbe, Roland Eghoghosoa Akhigbe, Oladele A. Afolabi, Ayodeji Folorusho Ajayi   +3 more
doaj   +1 more source

L-Arginine reverses maternal and pre-pubertal codeine exposure-induced sexual dysfunction via upregulation of androgen receptor gene and NO/cGMP signaling.

PLoS ONE, 2022
BackgroundAlthough codeine has been reported to enhance sexual activity by improving penile reflexes, it has been shown to impair fertility indices. Also, codeine impairs ovarian steroidogenesis and folliculogenesis.
Roland Eghoghosoa Akhigbe, Oladele A Afolabi, Ayodeji F Ajayi   +2 more
doaj   +1 more source

Should Codeine Still be Considered a WHO Essential Medicine?

Journal of Pharmacy & Pharmaceutical Sciences, 2021
Codeine continues to be widely used as an analgesic, antidiarrhoeal and antitussive agent. Its analgesic effect depends on its biotransformation to morphine, a strong opioid.
Boni Singu, Roger K Verbeeck
doaj   +1 more source

The Severity of Dependence Scale (SDS) for Codeine: Preliminary Investigation of the Psychometric Properties of the SDS in an Online Sample of Codeine Users From the UK

Frontiers in Psychiatry, 2021
Objective: Investigate the psychometric properties of the Severity of Dependence Scale (SDS) for codeine and its association with aberrant codeine related behaviors.Design: A voluntary and uncompensated cross-sectional online survey.Setting: Online ...
Paolo Deluca, Michelle Foley, Jacklyn Dunne, Andreas Kimergård   +3 more
doaj   +1 more source

Impact of Removing Nonprescription Codeine in Australia: Protocol for a Prospective Cohort Study

JMIR Research Protocols, 2020
BackgroundOn February 1, 2018, Australia rescheduled codeine to a prescription-only medication. Many concerns were associated with this change, including increased financial costs, reduced service accessibility, the potential for poorer pain management ...
McCoy, Jacqui, Nielsen, Suzanne, Bruno, Raimondo   +2 more
doaj   +1 more source

Study the Histopathological Effect Associated with Oral Overdose of Opioid Derivatives - on Liver and Kidney Tissue in Male Rats [PDF]

Basrah Journal of Veterinary Research, 2023
The current study aimed to ascertain the impact of acute codeine dose (0.50 and 1 ml/ 250g), on the histolopathological profile of the liver and kidney in male rats.
Yasmeen Mohammed
doaj   +1 more source

In vivo exposure to codeine induces reproductive toxicity: role of HER2 and p53/Bcl-2 signaling pathway

Heliyon, 2020
Several studies have implicated codeine use in the aetiopathogenesis of male infertility. The purpose of this study was to investigate the role of HER2, Ki67, oestrogen and p53/Bcl-2 signaling pathways and the possible outcome of codeine cessation on ...
A.F. Ajayi, R.E. Akhigbe
doaj   +1 more source

Effects of the FDA Codeine Safety Investigation on Racial and Geographic Disparities in Opioid Prescribing after Pediatric Tonsillectomy and/or Adenoidectomy

Global Pediatric Health, 2021
Objective. Our objective was to examine the impact of the U.S. FDA’s 2013 black box warning against codeine on codeine and other opioid prescription filling after pediatric tonsillectomy and/or adenoidectomy (T/A) overall and by child race and provider ...
Amy Lawrence, Jennifer N. Cooper, Katherine J. Deans, Peter C. Minneci, Sharon K. Wrona, Deena J. Chisolm   +5 more
doaj   +1 more source

Apoptotic inducement of neuronal cells by codeine: possible role of disrupted redox state and caspase 3 signaling

Heliyon, 2021
Background: Codeine, a common drug of abuse, has been reported to induce organ damage; however, there are scanty available data on the effects of codeine on the brain. Objective: Thus, we tested the hypothesis that redox dysregulation and inflammation of
A.F. Ajayi, R.E. Akhigbe
doaj   +1 more source

The importance of 6-MAM levels and morphine/codeine ratio in diagnosis of death among drug addicts [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Introduction/Objective. Heroin is metabolized to 6-monoacetylmorphine (6-MAM) and morphine. The objective of this study is to examine 6-MAM, morphine, and codeine relationships in order to distinguish deaths related to heroin consumption from deaths ...
Jakšić Vladimir, Mirić Dijana, Ilić Aleksandra, Matejić Suzana, Stević Snežana, Vitošević Zdravko   +5 more
doaj   +1 more source