Results 11 to 20 of about 27,730 (240)

Effect of codeine on CYP450 isoform activity of rats

Pharmaceutical Biology, 2017
Context: Codeine, also known as 3-methylmorphine, is an opiate used to treat pain, as a cough medicine and for diarrhoea. No study on the effects of codeine on the metabolic capacity of CYP enzyme is reported.
Shuanghu Wang, Yanwen Dong, Ke Su, Jing Zhang, Linyi Wang, Anyue Han, Congcong Wen, Xianqin Wang, Yan He   +8 more
doaj   +2 more sources

Comparison of the postoperative analgesic effects of paracetamol–codeine phosphate and naproxen sodium–codeine phosphate for lumbar disk surgery [PDF]

Kaohsiung Journal of Medical Sciences, 2015
The aim of this study was to compared the efficacy of paracetamol–codeine phosphate and naproxen sodium–codeine phosphate on postoperative pain and tramadol consumption during the first 24 hours after a lumbar disk surgery.
Reyhan Polat, Kevser Peker, Çiğdem Topçu Gülöksüz, Julide Ergil, Taylan Akkaya   +4 more
doaj   +2 more sources

Codeine and Metabolite Concentrations in the Breastfed Neonate. [PDF]

Paediatr Anaesth
Analgesic effect from codeine is from its metabolite, morphine. Morphine is formed by the O-demethylation of codeine and that enzyme is controlled by the cytochrome P450 2D6. More than 60 alleles in the CYP2D6 gene have been identified.
Anderson BJ, Hannam JA.
europepmc   +3 more sources

A Review of Analytical Methods for Codeine Determination

Molecules, 2021
Codeine is derived from morphine, an opioid analgesic, and has weaker analgesic and sedative effects than the parent molecule. This weak opioid is commonly used in combination with other drugs for over-the-counter cough relief medication.
Rimadani Pratiwi, Eka Noviana, Rizky Fauziati, Daniel Blascke Carrão, Firas Adinda Gandhi, Mutiara Aini Majid, Febrina Amelia Saputri   +6 more
doaj   +2 more sources

Apoptotic inducement of neuronal cells by codeine: possible role of disrupted redox state and caspase 3 signaling

Heliyon, 2021
Background: Codeine, a common drug of abuse, has been reported to induce organ damage; however, there are scanty available data on the effects of codeine on the brain. Objective: Thus, we tested the hypothesis that redox dysregulation and inflammation of
A.F. Ajayi, R.E. Akhigbe
doaj   +1 more source

A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk. [PDF]

PLoS ONE, 2013
Neonates are commonly exposed to maternal codeine through breast milk. Central Nervous System (CNS) depression has been reported in up to 24% of nurslings following codeine exposure.
Lauren E Kelly, Shahnaz A Chaudhry, Michael J Rieder, Geert 't Jong, Myla E Moretti, Andrea Lausman, Colin Ross, Howard Berger, Bruce Carleton, Michael R Hayden, Parvaz Madadi, Gideon Koren   +11 more
doaj   +1 more source

Spatial clustering of codeine use and its association with depression: a geospatial analysis of nationally representative South African data

Journal of Affective Disorders Reports, 2022
Background: There is an alarming trend in sub-Saharan Africa in the use of codeine-containing pharmaceuticals, but its risk of common comorbidities, such as mental health, remains unquantified at a national-level. We investigated the relationship between
Princess Nyoni, Diego F. Cuadros, Andrew Gibbs, Frank Tanser, Rob Slotow, Jonathan K Burns, Andrew Tomita   +6 more
doaj   +1 more source

Trends and characteristics of accidental and intentional codeine overdose deaths in Australia [PDF]

, 2015
Examines trends in codeine-related mortality rates in Australia, and the clinical and toxicological characteristics of codeine-related deaths. Abstract Objectives: To examine trends in codeine-related mortality rates in Australia, and the clinical and ...
Pilgrim, Jennifer, Hall, WD ; https://orcid.org/, Amanda Roxburgh, Saar, E, Nielsen, Suzanne, Hall, Wayne D., Degenhardt, L ; https://orcid.org/, Jennifer Pilgrim, Louisa Degenhardt, Eva Saar, Pilgrim, J, Lucinda Burns, Degenhardt, Louisa, Nielsen, S ; https://orcid.org/, Roxburgh, A ; https://orcid.org/, Suzanne Nielsen, Burns, L ; https://orcid.org/, Wayne D Hall, Roxburgh, Amanda, Burns, Lucinda, Saar, Eva   +20 more
core   +1 more source

Clinician Perspectives on Prescribing Restrictions and Opioid Pain Management in Australian Podiatric Practice: A Qualitative Study. [PDF]

J Foot Ankle Res
ABSTRACT Background Australian‐endorsed general podiatrists and podiatric surgeons (EGPs and EPSs, respectively) operate under a fixed prescribing formulary, the National Podiatry Scheduled Medicines List (NPSML), that restricts access to opioid analgesics including tramadol and tapentadol, despite emerging evidence questioning the efficacy of ...
Aquilina L, Kronenberg M, Kruger E, Tennant M, Park JS.   +4 more
europepmc   +2 more sources

A Single Site Population Study to Investigate CYP2D6 Phenotype of Patients with Persistent Non-Malignant Pain

Medicina, 2019
Background and Objectives: Codeine requires biotransformation by the CYP2D6 enzyme, encoded by the polymorphic CYP2D6 gene, to morphine for therapeutic efficacy. CYP2D6 phenotypes of poor, intermediate, and ultra-rapid metabolisers are at risk of codeine
Helen Radford, Karen H. Simpson, Suzanne Rogerson, Mark I. Johnson   +3 more
doaj   +1 more source