Results 41 to 50 of about 22,944 (196)

Population‐Stratified Distributions of Post‐Mortem Blood Drug Concentrations: An Epidemiological Framework for Contextual Interpretation

Drug Testing and Analysis, EarlyView.
Post‐mortem blood drug concentrations exhibit substantial overlap between deaths in which a drug was implicated and those in which it was not. Analysis of over 58,000 NPSUM cases demonstrates that demographic stratification does not resolve this uncertainty, reinforcing the need for contextual, evidence‐based interpretation rather than concentration ...
Thikra Algahtani, Kirsten L. Rock, Kathleen Rice‐Davies, Rebecca Lo, Benedict Morley, Stephen Morley, Caroline S. Copeland   +6 more
wiley   +1 more source

Comparison of the postoperative analgesic effects of paracetamol–codeine phosphate and naproxen sodium–codeine phosphate for lumbar disk surgery

Kaohsiung Journal of Medical Sciences, 2015
The aim of this study was to compared the efficacy of paracetamol–codeine phosphate and naproxen sodium–codeine phosphate on postoperative pain and tramadol consumption during the first 24 hours after a lumbar disk surgery.
Reyhan Polat, Kevser Peker, Çiğdem Topçu Gülöksüz, Julide Ergil, Taylan Akkaya   +4 more
doaj   +1 more source

Intra‐Individual Variability of Blood and Urinary Steroid Markers and the Response to Codeine Intake in Healthy Men and Women

Drug Testing and Analysis, EarlyView.
Short‐term codeine administration (1–3 days) caused individual alterations in Athlete Biological Passport steroid markers, including elevated urinary T/E ratios and decreased serum testosterone concentrations below individual thresholds, despite no significant changes at the group level.
Alexander Andersson, Basam Yousif, Anton Pohanka, Annica Börjesson, Mikael Lehtihet, Lena Ekström   +5 more
wiley   +1 more source

Dissolution monitoring of diclofenac sodium and codeine phosphate tablets using fibre optic chemical sensor assisted by dual-wavelength isosbestic point spectrophotometry

Pakistan Journal of Pharmaceutical Sciences, 2021
The purpose of this investigation was to establish a mathematical model for determining the dissolution of diclofenac sodium and codeine phosphate simultaneously.
Lu Zhang, Chunhui Lu, Xinxia Li, Jianguang Li   +3 more
doaj   +1 more source

Analgesic use, safety and pharmacokinetics of acetaminophen in equids: A structured scoping review

Equine Veterinary Journal, EarlyView.
Abstract Background Despite its frequent use in equine clinical practice, scientific data on the use of acetaminophen in horses remain limited. Objective To map and critically appraise the available evidence on the analgesic use, safety and pharmacokinetics of acetaminophen in horses. Study Design Structured scoping review.
Francisco Medina‐Bautista, Juan Manuel Serrano‐Rodríguez, María del Mar Granados   +2 more
wiley   +1 more source

Transdiagnostic and symptom‐domain associations between mental illnesses and future self‐connectedness versus future self‐valence

JCPP Advances, EarlyView.
Abstract Background Future time perspective dimensions have been linked to various mental illnesses. Given the tendency for mental illnesses to co‐occur, it is necessary to disentangle associations between future‐oriented constructs and shared versus symptom‐domain‐specific psychopathology.
Yi Yang, Ingrid Obsuth, Jean‐Louis van Gelder, Denis Ribeaud, Manuel Eisner, Xinxin Zhu, Aja Louise Murray   +6 more
wiley   +1 more source

Pharmacists’ experience with patients suspected to be addicted to over-the-counter codeine and their attitudes towards potential remediation strategies: a cross-sectional study

BMC Psychiatry
Background Croatia is one of the European Union (EU) countries where low-dose codeine products (LDCP) can be purchased over the counter (OTC) directly from community pharmacists without a prescription. The misuse and dependence potential of OTC LDCP have
Željana Margan Koletić, Blaženka Pavličić, Željko Ključević, Ana Soldo, Livia Puljak   +4 more
doaj   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

A Scalable Large Language Model‐Aided Approach for Mining Plant‐Compound Pairs From Scientific Literature

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding plant chemicals is vital for medicine and agriculture, but global data remain fragmented and biased. We developed an AI‐powered tool to automatically extract plant‐compound information from scientific literature at scale and low cost. Our analysis revealed significant knowledge gaps, particularly in the Southern Hemisphere. By efficiently
Adam Richard‐Bollans, Francesco Civita
wiley   +1 more source

Physiologically based pharmacokinetic modeling to predict the pharmacokinetics of codeine in different CYP2D6 phenotypes

Frontiers in Pharmacology
ObjectivesCodeine, a prodrug used as an opioid agonist, is metabolized to the active product morphine by CYP2D6. This study aimed to establish physiologically based pharmacokinetic (PBPK) models of codeine and morphine and explore the influence of CYP2D6
Yujie Yang, Xiqian Zhang, Yirong Wang, Heng Xi, Min Xu, Liang Zheng   +5 more
doaj   +1 more source