Results 21 to 30 of about 27,730 (240)

Opium trade and use during the Late Bronze Age: Organic residue analysis of ceramic vessels from the burials of Tel Yehud, Israel

open access: yesArchaeometry, EarlyView., 2022
Abstract Organic residue analysis was conducted on various vessels from burials at Tel Yehud, Israel. The analyses led to new reliable evidence for the presence of opioid alkaloids and their decomposition products. This research revitalizes a decades‐old discussion on the presence and function of the opium trade across a cultural region of utmost ...
Vanessa Linares   +5 more
wiley   +1 more source

Morphine-codeine interactions in rodents [PDF]

open access: yes
Rats given morphine-codeine combinations exhibited significantly increased hotplate reaction times compared with rats given an analgesic dose of one agent alone.
Blank, Jerome W.
core   +6 more sources

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO/TNF-α and caspase 3 activities.

open access: yesPLoS ONE, 2020
BackgroundCodeine, a 3-methylmorphine, and other related opioids have been implicated in androgen suppression, although the associated mechanisms remain unclear.AimTherefore, the objective of the current study was to elucidate the in vivo molecular ...
Roland Akhigbe, Ayodeji Ajayi
doaj   +1 more source

Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children. [PDF]

open access: yesBr J Clin Pharmacol
Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Rieder M.
europepmc   +2 more sources

Spray-Dried Engineered Escherichia coli Whole-Cell Biocatalysts Enable Cell Recycling and In Vivo α-Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture. [PDF]

open access: yesBiotechnol Bioeng
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Jahanian A   +4 more
europepmc   +2 more sources

Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review

open access: yesPain and Therapy, 2020
Introduction The objective of this systematic review is to reflect on assumptions in relation to codeine use in combination with other analgesics. Methods MEDLINE was searched according to the predetermined keywords and criteria.
Ivan Ćelić   +5 more
doaj   +1 more source

Cocrystal of Codeine and Cyclopentobarbital

open access: yes, 2023
The two-component compound formed by codeine and cyclopentobarbital was produced using grinding techniques and through evaporation from alcoholic solutions.
Thomas Gelbrich   +2 more
core   +1 more source

COMPARATIVE STUDY OF PAIN KILLER DRUGS EFFECTS AFTER THE DENTAL IMPLANT PLACEMENT IN THE ACTIVE ADULT POPULATION [PDF]

open access: yesRomanian Journal of Stomatology, 2019
There is controversy in recent studies on the use of NSAIDs used to control pain and swelling after the insertion of dental implants that may interfere with the osteointegration process.
Ruxandra Nicolette Voinea Georgescu   +5 more
doaj   +1 more source

THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS

open access: yesJurnal Kedokteran Diponegoro, 2020
Introduction : Paracetamol is an effective analgesic to relieve mild to moderate pain when it is used in therapeutic doses. Codeine is an opioid analgesic to relieve moderate to severe pain. Both are metabolized in the liver and have different mechanisms
Rona Ayu Hanifah   +3 more
doaj   +1 more source

A study of medical professionals’ perspectives on medicines containing codeine in South Africa

open access: yesSouth African Journal of Psychiatry, 2018
Background: Misuse of codeine available on prescription and over-the-counter (OTC) has been highlighted as a potential problem in South Africa. Objective: To examine the perceptions of medical professionals regarding codeine use (prescribed and OTC ...
Michelle Foley   +5 more
doaj   +1 more source

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