Results 21 to 30 of about 47,580 (219)

Laxatives do not improve symptoms of opioid-induced constipation: results of a patient survey [PDF]

open access: yes, 2017
Introduction: Laxatives are commonly used to treat opioid-induced constipation, the commonest and most bothersome complication of opioids. However, laxatives have a non-specific action and do not target underlying mechanisms of opioid-induced ...
Emmanuel, Anton   +2 more
core   +1 more source

Pharmacogenetics of analgesic drugs [PDF]

open access: yes, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R   +4 more
core   +1 more source

Post-mortem toxicology: A pilot study to evaluate the use of a Bayesian network to assess the likelihood of fatality [PDF]

open access: yes, 2015
The challenge of interpreting post-mortem drug concentrations is well documented and relies on appropriate sample collection, knowledge of case circumstances as well as reference to published tables of data, whilst taking into account the known issues of
Bolton, Jennifer   +3 more
core   +1 more source

Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review

open access: yesPain and Therapy, 2020
Introduction The objective of this systematic review is to reflect on assumptions in relation to codeine use in combination with other analgesics. Methods MEDLINE was searched according to the predetermined keywords and criteria.
Ivan Ćelić   +5 more
doaj   +1 more source

Characteristics of drug and dietary supplement inquiries by college athletes. [PDF]

open access: yes, 2010
BackgroundIn the United States, the National Center for Drug Free Sport manages the drug-testing programs for athletes of the National Collegiate Athletic Association (NCAA).
Ambrose, Peter J   +3 more
core   +1 more source

Effect of codeine on CYP450 isoform activity of rats

open access: yesPharmaceutical Biology, 2017
Context: Codeine, also known as 3-methylmorphine, is an opiate used to treat pain, as a cough medicine and for diarrhoea. No study on the effects of codeine on the metabolic capacity of CYP enzyme is reported.
Shuanghu Wang   +8 more
doaj   +1 more source

Content of alkaloids in ornamental Papaver somniferum L. cultivars growing in Estonia; pp. 34–39 [PDF]

open access: yesProceedings of the Estonian Academy of Sciences, 2017
The alkaloid content in industrial opium poppies (Papaver somniferum L.) has been studied by numerous authors, but not in ornamental cultivars.The aim of the study was to investigate the content of morphine, codeine, and papaverine in P.
Andres Meos, Liis Saks, Ain Raal
doaj   +1 more source

Unexpected Variation of the Codeine/Morphine Ratio Following Fatal Heroin Overdose [PDF]

open access: yes, 2014
Postmortem samples from 14 cases of suspected heroin overdose were subjected to a preliminary systematic toxicological analysis in order to highlight the presence of unknown exogenous compounds (e.g., drugs of abuse, alcohol) that may have played a ...
Cippitelli M, Gambaro V, Guerrini K
core   +1 more source

THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS

open access: yesJurnal Kedokteran Diponegoro, 2020
Introduction : Paracetamol is an effective analgesic to relieve mild to moderate pain when it is used in therapeutic doses. Codeine is an opioid analgesic to relieve moderate to severe pain. Both are metabolized in the liver and have different mechanisms
Rona Ayu Hanifah   +3 more
doaj   +1 more source

Postmortem tissue distribution of morphine and its metabolites in a series of heroin related deaths [PDF]

open access: yes, 2018
The abuse of heroin (diamorphine) and heroin deaths are growing around the world. The interpretation of the toxicological results from suspected heroin deaths is notoriously difficult especially in cases where there may be limited samples.
Beer, Lewis J.   +6 more
core   +5 more sources

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