Results 21 to 30 of about 22,944 (196)

A Review of Analytical Methods for Codeine Determination

Molecules, 2021
Codeine is derived from morphine, an opioid analgesic, and has weaker analgesic and sedative effects than the parent molecule. This weak opioid is commonly used in combination with other drugs for over-the-counter cough relief medication.
Rimadani Pratiwi, Eka Noviana, Rizky Fauziati, Daniel Blascke Carrão, Firas Adinda Gandhi, Mutiara Aini Majid, Febrina Amelia Saputri   +6 more
doaj   +1 more source

Effect of codeine on CYP450 isoform activity of rats

Pharmaceutical Biology, 2017
Context: Codeine, also known as 3-methylmorphine, is an opiate used to treat pain, as a cough medicine and for diarrhoea. No study on the effects of codeine on the metabolic capacity of CYP enzyme is reported.
Shuanghu Wang, Yanwen Dong, Ke Su, Jing Zhang, Linyi Wang, Anyue Han, Congcong Wen, Xianqin Wang, Yan He   +8 more
doaj   +1 more source

THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS

Jurnal Kedokteran Diponegoro, 2020
Introduction : Paracetamol is an effective analgesic to relieve mild to moderate pain when it is used in therapeutic doses. Codeine is an opioid analgesic to relieve moderate to severe pain. Both are metabolized in the liver and have different mechanisms
Rona Ayu Hanifah, Farah Hendara Ningrum, Erwin Kresnoadi, Satrio Adi Wicaksono   +3 more
doaj   +1 more source

COMPARATIVE STUDY OF PAIN KILLER DRUGS EFFECTS AFTER THE DENTAL IMPLANT PLACEMENT IN THE ACTIVE ADULT POPULATION [PDF]

Romanian Journal of Stomatology, 2019
There is controversy in recent studies on the use of NSAIDs used to control pain and swelling after the insertion of dental implants that may interfere with the osteointegration process.
Ruxandra Nicolette Voinea Georgescu, Cristian Niky Cumpătă, Mihaela Răescu, Mircea Gheorghiţă, Andreea Gabriela Nicola, Dana Cosac   +5 more
doaj   +1 more source

Codeine-induced sperm DNA damage is mediated predominantly by oxidative stress rather than apoptosis

Redox Report, 2020
Background: Opioids have been implicated to induce infertility. Although codeine remains the most used opioid for recreational purpose, no study has documented its effect on sperm quality.
Ayodeji Folorunso Ajayi, Roland Eghoghosoa Akhigbe   +1 more
doaj   +1 more source

Relationship Between Severe Respiratory Depression and Codeine-Containing Antitussives in Children: A Nested Case-Control Study

Journal of Epidemiology, 2020
Background: Guidelines recommend against all codeine use in children for its common indications of analgesia and cough suppression because of uncertain benefits and potential risk of death.
Sachiko Ono, Yosuke Ono, Daisuke Koide, Hideo Yasunaga   +3 more
doaj   +1 more source

Orofacial antinociceptive activity of codeine-associated geraniol in mice: a controlled triple-blind study [PDF]

Brazilian Oral Research
This is a nonclinical, controlled, and triple-blind study to investigate the effects of codeine-associated geraniol on the modulation of orofacial nociception and its potential central nervous system depressing effect in an animal model.
Ana Paula Lopes NUNES, Humberto Hugo Nunes de ANDRADE, Danielle da Nóbrega ALVES, Gleycyelly Rodrigues ARAÚJO, Mirian Graciela da Silva Stiebbe SALVADORI, Reinaldo Nóbrega de ALMEIDA, Ricardo Dias de CASTRO   +6 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

A comparative analysis of pharmacists’ perspectives on codeine use and misuse – a three country survey

Substance Abuse Treatment, Prevention, and Policy, 2018
Background The misuse of codeine is of increasing concern in a number of countries, particularly as this relates to over -the-counter pain and cough relief medication, and is also supplied as a prescription medicine. The study aimed to obtain and analyse
Tara Carney, John Wells, Charles D. H. Parry, Padraig McGuinness, Richard Harris, Marie Claire Van Hout   +5 more
doaj   +1 more source

Functional phenotyping of the CYP2D6 probe drug codeine in the horse

BMC Veterinary Research, 2021
Background In humans, the drug metabolizing enzyme CYP2D6 is highly polymorphic resulting in substantial differences in the metabolism of drugs including anti-arrhythmics, neuroleptics, and opioids.
S. R. Gretler, C. J. Finno, P. H. Kass, H. K. Knych   +3 more
doaj   +1 more source