Results 161 to 170 of about 758,251 (341)

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Remdesivir as a possible therapeutic option for the COVID-19 [PDF]

, 2020
Al-Homoud, Ali H., Al-Tawfiq, Jaffar A., Memish, Ziad A.   +2 more
core   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

2 Generation of new model systems for HIV infection to explore epigenetic effects of HIV integration site choice

Journal of Virus Eradication, 2017
J.K. Bialek, T. Walther, J. Hauber, U.C. Lange   +3 more
doaj   +1 more source

Evaluation of Antiviral Drug Synergy in an Infectious HCV System

, 2015
Billy Lin, Shanshan He, Hyung Joon Yim, T. Jake Liang, Zongyi Hu   +4 more
openalex   +1 more source

Changes in hepatitis C burden and treatment trends in Europe during the era of direct-acting antivirals: a modelling study [PDF]

, 2019
Qiushi Chen, Turgay Ayer, Emily D. Bethea, Fasiha Kanwal, Xiaojie Wang, Mark S. Roberts, Yueran Zhuo, Stefano Fagiuoli, Jörg Petersen, Jagpreet Chhatwal   +9 more
openalex   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

The GTPase Domain of MX2 Interacts with the HIV-1 Capsid, Enabling Its Short Isoform to Moderate Antiviral Restriction [PDF]

, 2019
Gilberto Betancor, Matthew D. J. Dicks, Jose M. Jiménez-Guardeño, Nehad Mohammed Ali, Luis Apolonia, Michael H. Malim   +5 more
openalex   +1 more source

Analysis of the Differential Expression and Antiviral Activity of Porcine Interferon-α In Vitro [PDF]

, 2023
Jianyu Fang, Qingxian Zhang, Yanyan Xi, Limin Lang, Keling Wang, Shaoyu Li   +5 more
openalex   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source