Results 191 to 200 of about 758,251 (341)

Decision letter: The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

, 2018
Bryan R. Cullen
openalex   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

In Silico Identification of Antiviral Peptides as Potential Leads Against Sudan Ebolavirus VP-40. [PDF]

Biomed Res Int
Omara B, Kiyimba K, Fofana FG, Diabaté O, Odur W, Jjingo D, Iramiot JS, Draleru P, Achia J, Shafiq M, Ul-Haq Z, Okella H, Odongo S.   +12 more
europepmc   +1 more source

Designing Novel Antiviral Peptides Targeting Dengue NS3 Protease Via Long Short-Term Memory Model, Molecular Docking and Molecular Dynamics Simulations

yuan
openalex   +1 more source

Faculty Opinions recommendation of Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection.

, 2019
Kim Lewis
openalex   +2 more sources

The small-molecule antiviral compound Molnupiravir: an exploration of its tautomers.

, 2021
Henry S. Rzepa
openalex   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Host Cell Virus Interactions: Molecular Mechanisms, Immune Modulation, Viral Pathogenesis, and Emerging Therapeutic Targets. [PDF]

Viruses
Alanazi A, Ibrahim MN, El Azab EF, Elithy MA.   +3 more
europepmc   +1 more source

A175 CAN HCV CORE ANTIGEN REPLACE HCV RNA TESTING IN THE ERA OF DIRECT-ACTING ANTIVIRALS? [PDF]

, 2018
Saeed H. Al Marzooqi, Marjolein van Tilborg, Raoel Maan, Johannes Vermehren, Benjamin Maasoumy, Tony Mazzulli, Andrés Duarte‐Rojo, Matthew Kowgier, Harry L.A. Janssen, Robert J. de Knegt, Jean–Michel Pawlotsky, Gavin Cloherty, Christoph Sarrazin, Heiner Wedemeyer, Jordan J. Feld   +14 more
openalex   +1 more source