Results 191 to 200 of about 928,338 (389)

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

Effective treatment of advanced Oropouche virus, Rift Valley fever virus, and Dabie bandavirus infections with 4'-fluorouridine

mBio
Oropouche virus (OROV), Rift Valley fever virus (RVFV), and Dabie bandavirus (DBV) are significant re-emerging and emerging human pathogens with major public health implications.
Jonna B. Westover, Kie Hoon Jung, Inioska Rojas, Kevin W. Bailey, Julio Landinez-Aponte, Gregory R. Blumeling, Shuli Mao, Alexander A. Kolykhalov, Michael G. Natchus, George R. Painter, Brian B. Gowen   +10 more
doaj   +1 more source

Future antiviral polymers by plasma processing

Progress in polymer science, 2021
Chuanlong Ma, A. Nikiforov, N. De Geyter, X. Dai, R. Morent, K. Ostrikov   +5 more
semanticscholar   +1 more source

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

Advanced Science, EarlyView.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh, Albert Kallon Koroma, Rajeev Kumar Pandey, Yongfang Wang, Jinnan Cheng, Philipp Haas, Mahyar Aghapour, Linda Krug, Adelheid Hainzl, Meinhard Wlaschek, Pallab Maity, Karin Scharffetter‐Kochanek   +11 more
wiley   +1 more source

Assessing antiretroviral drug (ARV) bioavailability in HIV tissue reservoirs using in vitro and in vivo pharmacokinetic (PK) studies with human primary lymphoid endothelial cells and mice

Journal of Virus Eradication, 2017
S. Dyavar, A. Podany, N. Gautam, Y. Alnouti, C. Fletcher, L. Winchester, T. Mykris, J. Weinhold, K. Campbell   +8 more
doaj   +1 more source

AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM [PDF]

, 1966
Michael W. Rytel, Richard E. Shope, Edwin D. Kilbourne   +2 more
openalex   +1 more source

Antiviral activities of flavonoids

Biomedicine and Pharmacotherapy, 2021
S. Badshah, S. Faisal, A. Muhammad, B. G. Poulson, A. Emwas, Mariusz Jaremko   +5 more
semanticscholar   +1 more source

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

Advanced Science, EarlyView.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen, Qing Zhang, Jiajia Li, Xia Zhou, Daxing Gao, Lu Li, Dabing Huang, Jizhou Wang, Zhutian Zeng   +8 more
wiley   +1 more source

Recent Advances in Designing Adeno-Associated Virus-Based Vaccines Against Viral Infections

Pharmaceutics
Over 80% of the world’s deadliest pandemics are caused by viral infections, and vaccination remains the most effective way to prevent these infections from spreading. Since the discovery of the first vaccine over two centuries ago, several vaccine design
Njabulo Mnyandu, Ridhwaanah Jacobs, Patrick Arbuthnot, Mohube Betty Maepa   +3 more
doaj   +1 more source

Honeysuckle‐Derived Nanovesicles Regulate Gut Microbiota for the Treatment of Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study explores honeysuckle‐derived nanovesicles (HNVs) for treating inflammatory bowel disease. Orally administered HNVs alleviates colitis in mice by repairing the gut barrier, reducing inflammation, and restoring a healthy gut microbiota.
Yuanyuan Wang, Yuanhao Zhou, Qingyuan Wu, Yishu Li, Yilin Huang, Kexin Yu, Ping Li, Zhenye Lv, Haotian Liu, Hai Zou, Huiyu Liu, Xiaozhou Mou   +11 more
wiley   +1 more source