Results 221 to 230 of about 758,251 (341)

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

The Emerging Promise of Pentacyclic Triterpenoid Derivatives as Novel Antiviral Agents Against SARS-CoV-2 Variants. [PDF]

Molecules
Wan X, Cui X, Liang K, Huang J, Chen K, Chen W, Song G.   +6 more
europepmc   +1 more source

Development of Innovative Antiviral Formulations with Potent Virucidal Activity Against SARS-CoV-2 and Influenza Viruses

Juthaporn Ponphaiboon, Wantanwa Krongrawa, Sontaya Limmatvapirat, Sukannika Tubtimsri, Akanitt Jittmittraphap, Pornsawan Leaungwutiwong, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop, Chutima Limmatvapirat   +9 more
openalex   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Synthesis of Toddacoumaquinone, a Coumarin-Naphthoquinone Dimer, and Its Antiviral Activities.

, 1995
Tsutomu Ishikawa, Kazumi Kotake, Ishii Hisashi   +2 more
openalex   +2 more sources

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

Correction for Huang et al., “Involvement of Viral MicroRNA in the Regulation of Antiviral Apoptosis in Shrimp” [PDF]

, 2018
Tianzhi Huang, Yalei Cui, Xiaobo Zhang
openalex   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Evaluation of the Antiviral Activity of a Natural Product, Schisandrin B, Against Rhabdovirus Infection in Chinese Rice Field Eels. [PDF]

Int J Mol Sci
Liu Y, Xue M, Xu C, Zhou Y, Jiang N, Meng Y, Li Y, Huang Z, Liu W, Fan Y.   +9 more
europepmc   +1 more source

Evaluate the Sustainability of Viral Response to Antiviral Treatment by IL33 Assessment among Hepatitis C virus Saudi Patients

, 2016
Nuha Mahmoud Hamdi, Haya Salem Al-Jurayb, Haifa M. Al-Nafea, Roaa Adnan Safar, Khulood Mohamed Al Eisa, Nagwa Mohamed Amin Aref   +5 more
openalex   +1 more source