Results 91 to 100 of about 250,897 (215)

Antiviral Activity of Dendritic Heparan Sulfate Mimetics against Respiratory Syncytial Virus and Herpes Simplex Virus‑1. [PDF]

ACS Omega
Yue Y, Chang A, Spijkers-Shaw S, Devlin R, Li Y, Rendle PM, Nutsford A, Sullivan-Hill B, Wang C, Zubkova OV, Netzler NE, Taylor JA.   +11 more
europepmc   +1 more source

GS‐9620 alleviates psoriasis‐like inflammation by regulating autophagy in keratinocytes

Animal Models and Experimental Medicine, EarlyView.
Psoriasis is an immune‐mediated inflammatory disease of the skin characterized by excessive proliferation and abnormal differentiation of keratinocytes. GS‐9620 can increase the expression of ATG5, ATG7 and ATG16L1, thereby regulating the autophagy of keratinocytes and inhibiting the secretion of related inflammatory factors.
Yansi Lyu, Wei Zhou, Pei Zhang, Chen Lin, Xin Wen, Zigang Zhao, Guoqiang Zhang, Qian Zhang, Si Chen   +8 more
wiley   +1 more source

Antiviral activity and chemical characterization of Egyptian Ziziphus spina-christi against human respiratory viruses. [PDF]

Sci Rep
Elkhrsawy A, Kutkat O, Moatasim Y, Refaey MS, Al-Karmalawy AA, Elabd E, Keshta A, Shaltout K, El-Shesheny R.   +8 more
europepmc   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Host-Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules. [PDF]

Adv Sci (Weinh)
Byun WG, Son S, Lee J, Lee M, Ko M, Zhao S, Kim JH, Vaithegi K, Kwon JH, Lee JH, Jeon S, Yi D, Zou P, Kim S, Park SB.   +14 more
europepmc   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Broad-spectrum antiviral activity of the synthetic rocaglate zotatifin against Mayaro virus and other viruses. [PDF]

Front Cell Infect Microbiol
Valdés-Torres P, Campos D, Galán-Jurado PE, Zegarra D, Tuñon-Lorenzo I, González-Castillo F, Blanquer M, Mewa JC, Rivas C, González-Santamaría J.   +9 more
europepmc   +1 more source

A Universal Nucleoside‐to‐Nucleoside‐5′‐Triphosphate Enzyme Cascade Driven by Polyphosphate

Angewandte Chemie International Edition, EarlyView.
Nucleoside‐5′‐triphosphates (NTPs) are essential components for the generation of nucleic acids, yet their chemical synthesis is hindered by the low yield of nucleoside phosphorylation. Here, we present a universal, two‐enzyme nucleoside‐to‐NTP cascade that is driven by polyphosphate.
Jonathan P. Suess, Nicolas V. Cornelissen   +1 more
wiley   +1 more source

Antiviral Activity of Eugenol Against Chinese Rice-Field Eel Rhabdovirus in Monopterus albus. [PDF]

Animals (Basel)
Jiang J, Xue M, Liu W, Zhou Y, Li Y, Fan Y.   +5 more
europepmc   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source