Results 221 to 230 of about 10,450,245 (405)

Teriflunomide and Epstein–Barr virus in a Spanish multiple sclerosis cohort: in vivo antiviral activity and clinical response [PDF]

, 2023
María Inmaculada Domínguez‐Mozo, Inés González‐Suarez, Luisa María Villar, Lucienne Costa‐Frossard, Noelia Villarrubia, Yolanda Aladro, Belén Pilo, Xavier Montalbán, Manuel Comabella, Ignacio Casanova‐Peño, María Luisa Martínez‐Ginés, José Manuel García‐Domínguez, Maria Ángel García‐Martínez, Rafael Arroyo, Roberto Álvarez‐Lafuente   +14 more
openalex   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Corrigendum: Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2

, 2023
Mark Thursz, Fouzia Sadiq, Julia A. Tree, Peter Karayiannis, David W. C. Beasley, Wanwissa Dejnirattisai, Juthathip Mongkolsapaya, Gavin Screaton, Matthew E. Wand, Michael J. Elmore, Miles W. Carroll, Ian Matthews, Howard Thomas   +12 more
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

IFN-λ4 Exhibits Differential Induction and Antiviral Activity in RSV and HMPV Infections. [PDF]

Viruses
Martínez-Espinoza I, Babawale PI, Guerrero-Plata A.   +2 more
europepmc   +1 more source

Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities

, 2020
Xu‐Hua Nong, Zhengchao Tu, Shu‐Hua Qi   +2 more
openalex   +1 more source

Antiviral activity of the combination of interferon and ribavirin against chikungunya virus: are the results conclusive? [PDF]

, 2016
Carolina Scagnolari, Beniamino Caputo, Giovanni Rezza, Guido Antonelli   +3 more
openalex   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Antiviral Activity of Glucosyl Hesperidin Against Feline Calicivirus. [PDF]

Microorganisms
Choi SS, Lee SH, Lee KA.
europepmc   +1 more source