Results 321 to 330 of about 10,450,245 (405)

Rubrolides A, D, P, T, U: Total Syntheses and Antibacterial Evaluation of Highly Brominated Marine Natural Products

ChemistryEurope, EarlyView.
Following the Danube Flow. The first total syntheses of highly brominated rubrolides T, U, and U‐analog, together with the efficient and divergent syntheses of rubrolides A, D, and P. The dibrominated key intermediate, obtained via a Suzuki‐Miyaura cross‐coupling reaction, is the centerpiece of the synthesis.
Jasmin Janneschütz, Paul G. Schebek, Alexander Meyer, Celina Haller, Sophia Khom, Wolfgang R. Streit, Ifey Alio, Nina Schützenmeister   +7 more
wiley   +1 more source

ACE2-Decoy-Conjugated PLGA-PEG Nanoparticles Loaded with Nafamostat for Potent Antiviral Activity. [PDF]

Viruses
Hou S, Zhang Y, Zheng X, Li R, Zhao T, Qiao H, Zhang X, Liu Z.   +7 more
europepmc   +1 more source

NH‐Sulfilimine Synthesis Catalyzed by Nonheme Iron(II) Complex

ChemistryEurope, EarlyView.
Sulfilimines are emerging as valuable functional group in modern medicinal chemistry. Yet, their catalytic preparation is underexplored compared to sulfoximines. Here, the iron‐catalyzed synthesis of 14 examples of unprotected sulfilimines in good yields, under aerobic atmosphere and at room temperature, is described.
Léa Tesson, Jean‐Pierre Mahy, Frédéric Avenier   +2 more
wiley   +1 more source

A Pyrido-Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus. [PDF]

J Med Virol
Plicanti E, Deiana A, Nottoli S, Lottini G, Ibba R, Piras S, Di Marzo C, Vegni S, Lai M, Pistello M, Carta A, Freer G.   +11 more
europepmc   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Correction: In vitro dual (anticancer and antiviral) activity of the carotenoids produced by haloalkaliphilic archaeon Natrialba sp. M6. [PDF]

Sci Rep
Hegazy GE, Abu-Serie MM, Abo-Elela GM, Ghozlan H, Sabry SA, Soliman NA, Abdel-Fattah YR.   +6 more
europepmc   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, EarlyView.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source

Antiviral activity of nitazoxanide against pseudorabies virus infection <i>in vitro</i>. [PDF]

Front Vet Sci
Tan L, Zhu P, Getu Z, Yang X, Zheng S, Duan Y, Wang J, Zhou Y, Hu Y, Wang Y, Yang Y, Zuo M, Yao J.   +12 more
europepmc   +1 more source

Dual Ligand‐Enabled Nondirected C─H Olefination of (Hetero)Arenes for the Synthesis of Clickable Derivatives

Chemistry – A European Journal, EarlyView.
We report an efficient method for late‐stage installation of “clickable” alkyne groups into diverse (hetero)arenes. Using a dual‐ligand palladium catalyst that combines an NASA ligand with an N‐heterocycle, an acrylate unit bearing a terminal alkyne can be introduced via nondirected C─H activation.
Tommaso Braga, Maria Hergert, Manuel van Gemmeren   +2 more
wiley   +1 more source