Results 361 to 370 of about 10,450,245 (405)
Some of the next articles are maybe not open access.
Nucleoside analogs with antiviral activity
Biochemical Pharmacology, 1976Effects of chemical agents on viruses are discussed with regard to inhibition of virus adsorption, inhibition of virus penetration and uncoating, and inhibition of an intracellular event. The following nucleosides are discussed with regard to desirable features, toxicity, solubility, and mutagenic and carcinogenic properties: 5-iodo-2'-deoxycytidine, 5-
W H, Prusoff, D C, Ward
openaire +2 more sources
Antiviral Activity of Tenuazonic Acid
Nature, 1963TENUAZONIC acid (I) was first isolated by Rosett et al.1 from culture filtrates of various strains of Alternaria tenuis. The recent report2 of antitumour activity of tenuazonic acid prompts us to report our results with this mould metabolite. During an antiviral screening programme culture filtrates of an Aspergillus were found to inhibit the ...
F A, MILLER +6 more
openaire +2 more sources
The antiviral activity of dideoxycytidine
Journal of Antimicrobial Chemotherapy, 19892',3'-Dideoxycytidine (ddc) is a 2',3'-dideoxypyrimidine nucleotide which has been shown to be active against human immunodeficiency virus type 1 (HIV-1) in cell cultures. This article reviews some of the laboratory studies with this antiviral compound, and available pharmacokinetic and toxicity data from phase 1 studies of ddc alone and in alternation
openaire +2 more sources
The Antiviral Activities of Tetherin
2013Tetherin (BST2/CD317) has emerged as a key host cell defense molecule, inhibiting the release and spread of diverse enveloped virions from infected cells. In this chapter, I review the molecular and cellular basis for tetherin's antiviral activities and the function of virally encoded countermeasures that disrupt its function. I further describe recent
openaire +3 more sources
The antiviral activity of Isoprinosine
Canadian Journal of Microbiology, 1972A hypothesis predicting that increase in the rate of synthesis of host messenger RNA would be associated with antiviral activity was examined. Biochemically, Isoprinosine or NPT-10381 (methisoprinol) increased the rate of rapid labeling of polyribosomal RNA and protein in uninfected monkey kidney cells in tissue culture.
P, Gordon, E R, Brown
openaire +2 more sources
Antiviral Activity of L-Asparaginase
Nature New Biology, 1971L-ASPARAGINASE has anti-leukaemic and immunosuppressive activities1 and following the observation that L-asparaginase inhibits plaque formation in L mouse fibroblast cultures by herpes simplex virus2, we report studies of the activity of the enzyme on the multiplication of several human and animal viruses in cell cultures. A preparation of L-asparagine-
R, Maral, G H, Werner
openaire +2 more sources
1998
Development of new antiviral drugs is needed and challenging. Antiviral drug discovery has focused on viral inhibition strategies principally directed at viral penetration and uncoating or viral genome replication, and the era of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) has helped regenerate interest in
openaire +1 more source
Development of new antiviral drugs is needed and challenging. Antiviral drug discovery has focused on viral inhibition strategies principally directed at viral penetration and uncoating or viral genome replication, and the era of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) has helped regenerate interest in
openaire +1 more source
Laboratory Markers of Antiviral Activity
Antiviral Therapy, 1998Quantitative assays for viral nucleic acids have been instrumental in monitoring the response of patients to various antiviral therapies. The level of viraemia is predictive of clinical outcome in that a reduced risk of progression to AIDS or death was observed with lower plasma human immunodeficiency virus (HIV) RNA levels.
C, Christopherson, S D, Lu, S, Kwok
openaire +2 more sources
Antiviral activity of cyclopentenone prostanoids
Trends in Microbiology, 1997Cyclopentenone prostanoids inhibit virus replication by turning on an intracellular defence response that involves the induction of cytoprotective heat-shock proteins, the modification of viral glycoprotein maturation and the control of NF-kappa B activation.
openaire +2 more sources
ANTIVIRAL ACTIVITY OF SELECTED BENZIMIDAZOLES.
Bollettino dell'Istituto sieroterapico milanese, 1963Sarà€ inserito alla riapertura delle ...
Fara GM, Cochrane KW
openaire +2 more sources