Results 121 to 130 of about 170,905 (253)

A host-centric morphological profiling approach to identify repurposed antiviral drugs. [PDF]

iScience
Asp E, Rietdijk J, Tampere M, Axelsson H, Njenda D, Potdar S, Kalman A, Georgieva P, Lapins M, Ballante F, Soler A, de Kort M, Aittokallio T, Zaliani A, Kuzikov M, Gribbon P, Lo D, Carreras-Puigvert J, Seashore-Ludlow B, Spjuth O, Östling P.   +20 more
europepmc   +1 more source

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence‐Associated Factor pMGF300‐2R

Advanced Science, EarlyView.
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Rui Luo, Jing Zhang, Ruojia Huang, Xianfeng Zhang, Lian‐Feng Li, Jing Lan, Zhanhao Lu, Yuan Sun, Tao Wang, Hua‐Ji Qiu   +9 more
wiley   +1 more source

An ATP‐Driven N Protein–DDX21 Molecular Switch Dynamically Controls SARS‐CoV‐2 RNA G‐Quadruplex Heterogeneity

Advanced Science, EarlyView.
An ATP‐driven molecular switch, comprising viral nucleocapsid (N) protein and host helicase DDX21, dynamically modulates SARS‐CoV‐2 RNA G‐quadruplex (G4) heterogeneity. These viral G4s feature non‐canonical ion‐dependence and act as energy‐sensitive structural checkpoints.
Ya‐Ting Zheng, Li‐Yan Zhai, Jie Jin, Qiu‐Ying Chen, Hang Fu, Xue‐Qian Sun, Ying Lu, Hui Li, Xi‐Miao Hou   +8 more
wiley   +1 more source

Emerging antiviral drugs and immunotherapy for chronic hepatitis B and associated liver disease. [PDF]

Front Immunol
Zhu C, Yang J, Sheng Y, Fang M.
europepmc   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Evaluation of the efficacy and mechanisms of azvudine in elderly patients with malignant tumors complicated by COVID-19

Acta Pharmaceutica Sinica B
Ranran Sun, Yihang Song, Zhe Li, Daming Wang, Zujiang Yu   +4 more
doaj   +1 more source

On topological co-index polynomials for predictive modeling of the physicochemical properties of antiviral drugs. [PDF]

Sci Rep
Meharban S, Ullah A, Zaman S, Abd-Elmonem A, Ali P, Alhubieshi N, Belay MB.   +6 more
europepmc   +1 more source

Unlocking Li/Mg‐Based Photochemical Nitration Platforms for Anticancer Drug Discovery

Advanced Science, EarlyView.
Two low‐toxicity light main‐group metal photochemical systems based on lithium and magnesium are constructed for selective C(sp2)‐H (di)nitration of anilines. The obtained dinitrated products exhibit anti‐HCC (hepatocellular carcinoma) and anti‐KYSE30 cell activities, holding promise as novel antitumor candidates.
Qian Wan, Jiali Zhu, Shanshuo Liu, Luchuan Ou, Huizhen Wang, Yu Lan, Zhou Dong, Yihang Bai, Wei Yang, Shihan Liu, Yan Qiao, Shi‐Jun Li, Zhigang Ren, Linbin Niu   +13 more
wiley   +1 more source

Repurposing antiviral drugs targeting RNA viruses: A focus on the fusion protein of human metapneumovirus. [PDF]

North Clin Istanb
Aras M, Yayintas OT.
europepmc   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source