Results 181 to 190 of about 4,144,524 (396)

Additive Effect of Neutralizing Antibody and Antiviral Drug Treatment in Preventing Virus Escape and Persistence [PDF]

, 2000
Peter Seiler, Beatrice M. Senn, Paul Klenerman, Ulrich Kalinke, Hans Hengartner, Rolf M. Zinkernagel   +5 more
openalex   +1 more source

Research on the bio-distribution of interferon gamma-containing pharmacocytes [PDF]

, 2014
Viral hepatitis B and C- is a widespread infectious disease of the liver and is a potential threat to human life. Treatment of HCV and HBV requires prolonged (parenteral or oral) administration of antiviral and immune-stimulating agents, which often ...
Askarova, Sholpan, Ibrasheva, D., Idrissova, D., Masoud, A., Umbayev, B.   +4 more
core  

Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1

Advanced Science, EarlyView.
TREX1 antagonizes DNA sensor cGAS by degrading cytosolic DNA. This work identifies gigaxonin as a molecular switch that coordinates DNA sensing and clearance pathways to amplify antiviral responses. Under the steady state, gigaxonin maintains cellular homeostasis by mediating TREX1 ubiquitination and proteasomal degradation. During DNA virus infection,
Ben‐Zhe Ji, Jie Wang, Yi Tu, Shan Zhang, Yong‐Sheng Wei, Yan He, Bin Zhang, Qing‐Qing Zhao, Hao‐Min Hu, Yu Liu   +9 more
wiley   +1 more source

Targeting HDAC and PARP Enhances STING‐Dependent Antitumor Immunity in STING‐Deficient Tumor

Advanced Science, EarlyView.
Dual HDAC and PARP inhibition restores STING signaling, enhances interferon response, and boosts antitumor immunity in STING‐deficient tumors. . Abstract The stimulator of interferon genes (STING)‐mediated innate immune pathway plays an important role in tumor immunosurveillance.
Chengzhou Mao, Weiwen Fan, Jiaqi Liu, Fangzhou Yang, Wenkai Li, Lulu Li, Zhichao Shi, Qinyuan Li, Zigao Yuan, Yuyang Jiang, Bizhu Chu   +10 more
wiley   +1 more source

Researches on Chemotherapeutic Drugs against Viruses. XXVI. Syntheses and Antiviral Activity of N, N-Dimethyl-2-(p-alkylbenzhydrylthio) ethylamine and N, N-Dimethyl-2-(p-alkylthiobenzhydrylthio) ethylamine.

, 1960
Kiyoshi Takahashi, Keiko Ohki, Toyoharu Mizuma, Shigeshi Toyoshima   +3 more
openalex   +2 more sources

Reaction of cis- and trans-Dichlorotetra(Dimethylsulfoxide)Ruthenium(II) With the Antiviral Drug Acyclovir [PDF]

, 2000
A. Koutsodimou, Giovanni Natile
openalex   +1 more source

Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis

Cell Communication and Signaling
Background Malaria remains a global health burden, and the emergence and increasing spread of drug resistance to current antimalarials poses a major challenge to malaria control.
Peng Gao, Jianyou Wang, Huan Tang, Huanhuan Pang, Jiemei Liu, Chen Wang, Fei Xia, Honglin Chen, Liting Xu, Junzhe Zhang, Lixia Yuan, Guang Han, Jigang Wang, Gang Liu   +13 more
doaj   +1 more source

Use of Drug Effect Interaction Modeling with Monte Carlo Simulation To Examine the Impact of Dosing Interval on the Projected Antiviral Activity of the Combination of Abacavir and Amprenavir [PDF]

, 2000
George L. Drusano, David Z. D’Argenio, Sandra L. Preston, Carlo Barone, William Symonds, Stephen W. LaFon, M. Brooke Rogers, William Prince, Alan Bye, John A. Bilello   +9 more
openalex   +1 more source

The Advent Of Cytomegalovirus Infection In HIV Infected Patients: A review [PDF]

, 2004
Cytomegalovirus is considered as one among the long list of latent infections in humans that although normally controlled by the cellular immune response, gets activated after HIV infection takes its role on infecting the T4 lymphocytes. Clinical disease
Kirubakaran Isaac, Dr Sundar
core   +1 more source

Use of antiviral drugs to reduce COVID-19 transmission

Lancet Global Health, 2020
O. Mitjà, B. Clotet
semanticscholar   +1 more source