Results 221 to 230 of about 4,144,524 (396)

Correlation between the predicted and the observed biological activity of the symmetric and nonsymmetric cyclic urea derivatives used as HIV‐1 protease inhibitors. A 3D‐QSAR‐CoMFA method for new antiviral drug design [PDF]

, 2003
Speranța Avram, I. Svab, Cristian Bologa, Maria‐Luiza Flonta   +3 more
openalex   +1 more source

Engineering Metal‐Organic‐Framework‐Based STING Nanoagonists for PROTAC‐Enhanced Cancer Chemo‐Metalloimmunotherapy

Advanced Science, EarlyView.
Schematic overview of PROTAC‐enhanced chemo‐metalloimmunotherapy, integrating senescence induction, multi‐modal STING pathway activation, PD‐L1 blockade, and immune amplification via coordinated PROTACs, metal ions, and chemotherapy to elicit robust antitumor immunity and circumvent immune evasion.
Zhenzhen Chen, Zhe Feng, Siyuan Wang, Jingjing Zhang   +3 more
wiley   +1 more source

Does a SPR-Based Cell-Based Assay Provide Reliable Results on the Toxicity and Efficacy of Antiviral Drugs? [PDF]

Sensors (Basel)
Genova-Kalou P, Hikova E, Kereziev T, Kolev P, Mankov V, Veselinov P, Valkov T, Dyankov G.   +7 more
europepmc   +1 more source

Antiviral drug developments [PDF]

, 2003
Lutz Gissmann
openalex   +1 more source

Antiviral drug resistance [PDF]

BMJ, 1996
D, Pillay, A M, Geddes
openaire   +2 more sources

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, EarlyView.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

High‐Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15‐Specific Protease mUSP18

Angewandte Chemie, EarlyView.
Deubiquitinases (DUBs) and Ub‐like proteases are attractive but challenging drug targets. We developed a high‐throughput synthesis method and prepared a 7536‐member cyanimide DUB‐targeted compound library in 1536‐well plates, using Echo acoustic dispensing. Screening yielded a selective, 35 nM inhibitor of mUSP18, the main ISG15 protease.
Raymond Kooij, Vito Pol, Jin Gan, Bjorn R. van Doodewaerd, Aysegul Sapmaz, Marta Campos Alonso, Günter Fritz, Klaus‐Peter Knobeloch, Paul P. Geurink   +8 more
wiley   +2 more sources

Chronic infection with hepatitis B viruses and antiviral drug evaluation in uPA mice after liver repopulation with tupaia hepatocytes [PDF]

, 2004
Maura Dandri, Martin R. Burda, David M. Zuckerman, Karsten Wursthorn, Urte Matschl, Joerg M. Pollok, Xavier Rogiers, Andreas Gocht, Josef Köck, Hubert E. Blum, Fritz von Weizsäcker, Joerg Petersen   +11 more
openalex   +1 more source

Mechanistic Insights in Surface Engineering of Micro‐/Nanocomposite Phase Change Materials for Thermal Energy Storage: A Review

Advanced Energy and Sustainability Research, EarlyView.
This review examines surface‐engineered phase change material composites as vital solutions for escalating thermal energy storage demands driven by urbanization. It elucidates their enhanced performance through chemical mechanisms, diverse compositions, and preparation strategies, emphasizing the role of carbon‐based additives in improving thermal ...
Laxman Singh, Saravanakumar Balakrishnan, Joseph Johnson William, Sheikdawood Parveen, Ponnachiyur Aruchamy Periasamy, Rajeev Kumar, Anshuman Srivastava, Sunil Kumar, Amit Kumar Shringi, Dimple Kumari, Ambrish Singh, Fei Yan   +11 more
wiley   +1 more source

A paradigmatic approach to the molecular descriptor computation for some antiviral drugs. [PDF]

Heliyon, 2023
Ghani MU, Imran M, Sampathkumar S, Tchier F, Pattabiraman K, Jan AZ.   +5 more
europepmc   +1 more source