Results 1 to 10 of about 6,902 (163)

Construction of anti-HER2 affibody-directed CAR-NK and its synergistic effects with doxorubicin-loaded nanodrug against HER2-positive breast cancer [PDF]

Frontiers in Immunology
IntroductionChimeric antigen receptor (CAR)-engineered T or natural killer (NK) cells are a promising approach for cancer immunotherapy. The leading region of the CAR structure is generally a single-chain antibody (scFv) fragment specific for a tumor ...
Xuesong He, Xuesong He, Zhaoyuan Liang, Qing Liu, Xiaofei Zhang, Hao Liang, Runqing Jia, Wang Sheng   +7 more
doaj   +2 more sources

The Tomato Transcription Factor RAV Affects the Systemic Infection of TYLCV by Interacting With V2. [PDF]

Mol Plant Pathol
This study investigated the interaction between TYLCV V2 and tomato transcription factor SlRAV2: SlRAV2 enhances the RSS activity of V2 by strengthening its binding to 21‐nt ds‐siRNA, V2 enhances SlRAV2's SlPR1 promoter regulation and their interaction inhibits systemic spread of the virus from infiltrated leaves to systemic leaves.
Zhang C, Jia X, Fan G, Ren X, Han X, Jiao X, Cheng Y, Cheng Y, Liu Z, Yuan Z, Chen Y.   +10 more
europepmc   +2 more sources

Improving the Transduction Efficiency and Antitumor Effect of Conditionally Replicative Adenovirus by Application of 6-cyclohexyl Methyl-β-D-maltoside

Molecules, 2023
As a tumor-targeting oncolytic adenovirus (Ad), conditionally replicating adenovirus (CRAd) can access the cell interior by binding to coxsackievirus-Ad receptors (CARs) and specifically replicate and destroy cancer cells without lethal effects on normal
Wenjing Lu, Yaping Fang, Xue Meng, Xiaoli Wang, Wenbo Liu, Mengdong Liu, Ping Zhang   +6 more
doaj   +1 more source

Association analysis of BclI with benign lymphoepithelial lesions of the lacrimal gland and glucocorticoids resistance [PDF]

International Journal of Ophthalmology, 2023
AIM: To evaluate the relationship between gene polymorphism (BclI, ER22/23EK, N363S) and the occurrence, progression and sensitivity to glucocorticoid of lacrimal gland benign lymphoepithelial lesion (LGBLEL).
Xu-Juan Zhang, Peng-Xiang Zhao, Ming-Shen Ma, Hao Wu, Rui Liu, Hui Wang, Meng-Yu Liu, Fei Xie, Xue-Mei Ma   +8 more
doaj   +1 more source

Coordinated modulation of long non-coding RNA ASBEL and curcumin co-delivery through multicomponent nanocomplexes for synchronous triple-negative breast cancer theranostics

Journal of Nanobiotechnology, 2023
Background Abnormally regulated long non-coding RNAs (lncRNAs) functions in cancer emphasize their potential to serve as potential targets for cancer therapeutic intervention.
Xuesong He, Fengjuan Lin, Runqing Jia, Yang Xia, Zhaoyuan Liang, Xiangqian Xiao, Qin Hu, Xiongwei Deng, Qun Li, Wang Sheng   +9 more
doaj   +1 more source

Missing link between tissue specific expressing pattern of ERβ and the clinical manifestations in LGBLEL

Frontiers in Medicine, 2023
PurposeLacrimal gland benign lymphoepithelial lesion (LGBLEL) is an IgG4-related disease of unknown etiology with a risk for malignant transformation.
Xujuan Zhang, Xujuan Zhang, Xujuan Zhang, Pengxiang Zhao, Pengxiang Zhao, Pengxiang Zhao, Mingshen Ma, Hao Wu, Hao Wu, Hao Wu, Rui Liu, Ziyi Liu, Ziyi Liu, Ziyi Liu, Zisong Cai, Zisong Cai, Zisong Cai, Mengyu Liu, Mengyu Liu, Mengyu Liu, Fei Xie, Fei Xie, Fei Xie, Xuemei Ma, Xuemei Ma, Xuemei Ma   +25 more
doaj   +1 more source

RNA binding protein SAMD4: current knowledge and future perspectives

Cell & Bioscience, 2023
SAMD4 protein family is a class of novel RNA-binding proteins that can mediate post-transcriptional regulation and translation repression in eukaryotes, which are highly conserved from yeast to humans during evolution.
Xin-Ya Wang, Li-Na Zhang
doaj   +1 more source

Adaptive secure malware efficient machine learning algorithm for healthcare data

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract Malware software now encrypts the data of Internet of Things (IoT) enabled fog nodes, preventing the victim from accessing it unless they pay a ransom to the attacker. The ransom injunction is constantly accompanied by a deadline. These days, ransomware attacks are too common on IoT healthcare devices.
Mazin Abed Mohammed, Abdullah Lakhan, Dilovan Asaad Zebari, Karrar Hameed Abdulkareem, Jan Nedoma, Radek Martinek, Usman Tariq, Majed Alhaisoni, Prayag Tiwari   +8 more
wiley   +1 more source

HPV18 E6 inhibits α‐ketoglutarate‐induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway

FEBS Open Bio, 2023
Oncogene E6 plays a critical role in the development and progression of esophageal cancer caused by human papillomavirus (HPV) infection. Alpha‐ketoglutarate (AKG) is a key metabolite in the tricarboxylic acid cycle and has been widely used as a dietary ...
Duo Tang, Yuchen Zheng, Guozhen Wang, Chao Sheng, Zijia Liu, Biqi Wang, Qi Zong, Yuchen Zhang, Xiaonan Hou, Mengfei Yao, Zhixiang Zhou   +10 more
doaj   +1 more source

PROFIL PENGGUNAAN OBAT ANTIVIRUS COVID-19 DI RSUD dr. MURJANI-SAMPIT

JIIS: Jurnal Ilmiah Ibnu Sina, 2022
Coronavirus Disease 2019 (Covid-19) merupakan penyakit menular yang ditimbulkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2).  World Health Organization (WHO) sampai dengan saat ini masih menetapkan Covid-19 sebagai pandemi global ...
Etik Suryanti, Abdul Rahem, Anita Purnamayanti   +2 more
doaj   +3 more sources