Results 51 to 60 of about 3,291 (290)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

TO THE PROBLEM OF OVERCOMING LEXICAL INTERFERENCE AT THE LESSONS OF A FOREIGN (LEVEL OF SECONDARY EDUCATION) [PDF]

Актуальные проблемы филологии и педагогической лингвистики, 2017
The article is devoted to investigation of the peculiarities of lexical interference issue in teaching foreign languages, and an attempt to design a complex of special activities in order to overcome this problem.
Koroleva Natalia M.
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Antonym canonicity: Temporal and contextual manipulations

, 2014
in UndeterminedPrevious research on antonyms has shown that some pairings form more felicitous couplings than others. Following up on that research, we conducted two semantic categorization experiments using Event Related Potentials to establish whether ...
Lindgren, Magnus, Paradis, Carita, van de Weijer, Joost, Willners, Caroline, Paradis, Carita,, Willners, Caroline,, van de Weijer, Joost,, Lund University., Lindgren, Magnus,   +8 more
core   +1 more source

Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization

NeuroImage: Clinical, 2015
Background and purpose: Functional magnetic resonance imaging (fMRI) is a non-invasive pre-surgical tool used to assess localization and lateralization of language function in brain tumor and vascular lesion patients in order to guide neurosurgeons as ...
Tanvi N. Nadkarni, Matthew J. Andreoli, Veena A. Nair, Peng Yin, Brittany M. Young, Bornali Kundu, Joshua Pankratz, Andrew Radtke, Ryan Holdsworth, John S. Kuo, Aaron S. Field, Mustafa K. Baskaya, Chad H. Moritz, M. Elizabeth Meyerand, Vivek Prabhakaran   +14 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Negated Adjectives and Antonyms in Distributional Semantics: not similar?

IJCoL, 2019
We investigate the relation between negated adjectives and antonyms pairs in English (e.g., not cold vs. hot - cold) using Distributional Semantics. We build vector representations of a set of antonyms and their negations on the basis of their contexts ...
Laura Aina, Raffaella Bernardi, Raquel Fernández   +2 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Electrophysiological Responses to Expectancy Violations in Semantic and Gambling Tasks: A Comparison of Different EEG Reference Approaches

Frontiers in Neuroscience, 2018
Dynamically evaluating the outcomes of our actions and thoughts is a fundamental cognitive ability. Given its excellent temporal resolution, the event-related potential (ERP) technology has been used to address this issue. The feedback-related negativity
Ya Li, Yongchun Wang, Baoqiang Zhang, Yonghui Wang, Xiaolin Zhou, Xiaolin Zhou, Xiaolin Zhou, Xiaolin Zhou   +7 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source