Results 61 to 70 of about 3,291 (290)

The Antonym Construction: A Comparison between English and Mandarin [PDF]

open access: yes
All languages have antonym pairs but may differ in the ways of using them. The use of antonymy in the form of antonym co-occurrence has been examined and compared between English and Mandarin with the conclusion that antonym pairs could co-occur on ...
Chen, Lixin
core   +2 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

The Comparative Effect of Antonym in-Text Glosses and Description in-Text Glosses on EFL Learners' Reading Comprehensio [PDF]

open access: yesJournal of English Language Pedagogy and Practice, 2019
The present study was carried out to investigate the comparative effect of antonym in-text glosses and description in-text glosses on a group of Iranian EFL learners' reading comprehension.
Hanieh Ghasemi, Mona Khabiri
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Asymmetric inference towards the antonym: Experiments into the polarity and morphology of negated adjectives

open access: yesGlossa, 2017
In this paper, we investigate the interpretation of negated antonyms. A sentence such as Peter is not tall can be understood as meaning either that Peter is not tall tout court or that Peter is rather short (inference towards the antonym; ITA).
Benjamin Spector   +2 more
doaj   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Using corpora to investigate antonym acquisition

open access: yes, 2005
In this study, a purpose-built corpus, containing both child-produced and child-directed speech, is used to conduct a longitudinal examination of antonym use among children from the age of two to five years old.
M. Lynne Murphy (4460917)   +3 more
core   +1 more source

SYNONYMS AND ANTONYMS

open access: yesNotes and Queries
This article explores the importance of synonyms and antonyms in English language learning. It emphasizes how these elements enhance students’ vocabulary, comprehension, and expressive abilities. The article also discusses modern teaching approaches, digital tools, and assessment methods used in language education.
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

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