Results 51 to 60 of about 14,942 (219)

Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin. [PDF]

, 2018
While mutations in the fragile X mental retardation-1 (FMR1) gene are associated with varying reproductive outcomes in females, the effects of a complete lack of FMR1 expression are not known.
Ascano, M, Mok-Lin, E, Rosenwaks, Z, Serganov, A, Tuschl, T, Williams, Z   +5 more
core   +2 more sources

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome. [PDF]

, 2019
Context:In women with polycystic ovary syndrome (PCOS), 17-hydroxyprogesterone (17-OHP) responses to gonadotropin stimulation vary from increased to indistinguishable compared with normal controls.
Chang, R Jeffrey, Duleba, Antoni J, Garzo, Gabriel, Homer, Michael V, Lawson, Mark A, Toloubeydokhti, Tannaz   +5 more
core   +1 more source

Computer-Generated Ovaries to Assist Follicle Counting Experiments [PDF]

, 2015
Precise estimation of the number of follicles in ovaries is of key importance in the field of reproductive biology, both from a developmental point of view, where follicle numbers are determined at specific time points, as well as from a therapeutic ...
A Gougeon, A Gougeon, AE Falender, Angelos Skodras, C Sforza, DC Sterio, GI Perez, Gianluca Marcelli, HJ Adèr, HJ Gundersen, J Canning, JB Kerr, JE Coxworth, JS Charleston, M Myers, Norbert Gleicher, P Da Silva-Buttkus, PB Hoyer, VC Howard   +18 more
core   +3 more sources

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Improving inter-observer variability in the evaluation of ultrasonographic features of polycystic ovaries [PDF]

, 2008
Background We recently reported poor inter-observer agreement in identifying and quantifying individual ultrasonographic features of polycystic ovaries. Our objective was to determine the effect of a training workshop on reducing inter-observer variation
Marla E Lujan, Donna R Chizen, Andrew K Peppin, Stefan Kriegler, David A Leswick, Terri G Bloski, Roger A Pierson, Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group., R Azziz, A Balen, JK Zawadzki Dunaif, A., J Adams, DW Polson, WM Hague, RN Clayton, CM Farquhar, E Carmina, K Michelmore, E Cela, J Cresswell, AH Balen, S Jonard, D Dewailly, SA Amer, ME Lujan Peppin AK,, D Ferriman, HF Escobar-Morreale, LG Nardo, GP Adams R.A. Piers, LI Lin, JR Landis, SE Widmalm, J Ludbrook, AR Baerwald, GJ Scheffer, K Jayaprakasan, E Diamanti-Kandarakis, RV Higgins, IY Jarvela, NJ Raine-Fenning, LT Merce, S Jonard, AR Baerwald   +42 more
core   +2 more sources

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Comparison of Automated Anti-Müllerian Hormone Assays and Antral Follicle Count in Predicting Ovarian Response During Ovarian Stimulation

Fertility & Reproduction, 2019
Objective: Various parameters had been used to predict ovarian response. Among them, Anti-Müllerian Hormone (AMH) and antral follicle count (AFC) demonstrate the most favourable analytical and performance characteristics.
Eek Chaw Tan, Pallavi Chincholkar, Su Ling Yu, Serene Liqing Lim, Rajkumaralal Renuka, Tze Tein Yong, Chin Pin Yeo, Hemashree Rajesh   +7 more
doaj   +1 more source

Species-specific differences in follicular antral sizes result from diffusion-based limitations on the thickness of the granulosa cell layer

, 2013
The size of mature oocytes is similar across mammalian species, yet the size of ovarian follicles increases with species size, with some ovarian follicles reaching diameters more than 1000-fold the size of the enclosed oocyte.
Bächler, M., De Geyter, Ch., Iber, D., Menshykau, D.   +3 more
core   +1 more source

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis [PDF]

, 2017
Laparoscopic ovarian drilling (LOD) has been widely used as an effective treatment of anovulatory women with polycystic ovarian syndrome (PCOS). However, there has been a growing concern over a possible damaging effect of this procedure on ovarian ...
Ahmed A Mohamed, Ali H Yosef, Api, Cathryn James, Farquhar, Farzadi, Giampaolino, Hull, Lambert-Messerlian, Mohamed, Raffi, Rezk, Robertson, Saad A Amer, Seyam, Sunj, Sunj, Tarek T El Shamy, Weenen   +18 more
core   +2 more sources