Results 31 to 40 of about 58,847 (249)

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

Determination of the Normal Position of the Anus in Taiwanese Infants

open access: yesPediatrics and Neonatology, 2009
Anterior displacement of the anus has been reported to be a cause of chronic constipation amongst young children. However, the normal position of the anus has not been studied in Taiwan.
Wai-Tao Chan   +4 more
doaj   +1 more source

The effect of Covid-19 phobia on work stress and psychological resilience of nurses exposed to surgical smoke in the operating room

open access: yesMedicine Science, 2022
The purpose of the study is to determine the effect of Covid-19 Phobia on the work stress and psychological resilience of nurses exposed to surgical smoke in the operating room emergency surgical interventions.
Gurkan Kapikiran   +2 more
doaj   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Stereoselective Construction of Tertiary Homoallyl Alcohols and Ethers by Nucleophilic Substitution at Quaternary Carbon Stereocenters

open access: yesAngewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023
A highly efficient stereoinvertive nucleophilic substitution at the quaternary carbon stereocenter of cyclopropyl carbinol derivatives using water, alcohols and phenols as nucleophiles is reported. A variety of highly sterically hindered tertiary alkyl ethers and alcohols with adjacent tertiary carbon stereocenters are obtained in good yields with ...
Xu Chen, Kaushalendra Patel, Ilan Marek
wiley   +1 more source

Human papillomavirus infection in multiple sites

open access: yesDST, 2022
Introduction: Studies concerning human papillomavirus natural history have been focused on cervical infection and disease, but have scarcely described anal infections, especially in clinically health population.
Silvia Maria Baeta Cavalcanti   +3 more
doaj  

Establishment and biological characterization of radioresistant colorectal cancer cell lines

open access: yesFEBS Open Bio, EarlyView.
Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu   +10 more
wiley   +1 more source

Is screening for anal squamous intraepithelial lesions in women with genital human papillomavirus intraepithelial lesions necessary?

open access: yesDST, 2022
Introduction: There seems to be a fairly close relationship between genital and anal lesions associated with human papillomavirus (HPV) and with the pathogenesis of malignancies in such sites.
Francisco Eugênio de Vasconcelos Filho   +4 more
doaj  

Posterior Sagittal Anorectoplasty for Acquired Imperforate Anus Complicated by Anorectal Necrosis: A Case Report

open access: yesChildren, 2022
Anorectal necrosis is an uncommon lethal disease in children, characterized by necrosis of the mucosa of the anus and rectum. The difference between anorectal necrosis and Fournier’s gangrene is that anorectal necrosis does not affect the genital organs.
Yea-Ling Chen   +5 more
doaj   +1 more source

Geometric and dosimetric evaluation of a commercial AI auto‐contouring tool on multiple anatomical sites in CT scans

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Current radiotherapy practices rely on manual contouring of CT scans, which is time‐consuming, prone to variability, and requires highly trained experts. There is a need for more efficient and consistent contouring methods. This study evaluated the performance of the Varian Ethos AI auto‐contouring tool to assess its potential integration into
Robert N. Finnegan   +6 more
wiley   +1 more source

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