Results 31 to 40 of about 21,419 (297)

Tratamento conservador do carcinoma do canal anal

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Relatar os resultados do tratamento conservador do carcinoma de canal anal com radioterapia e quimioterapia do Centro de Tratamento e Pesquisa Hospital do Câncer A.C. Camargo.
Ricardo Akiyoshi Nakamura, Robson Ferrigno, João Victor Salvajoli, Inês Nobuko Nishimoto, Waldec Jorge David Filho, Ademar Lopes   +5 more
doaj   +1 more source

Anal cancer: an essay on etiology, risk conditions, vulnerability, and care of carriers

DST, 2022
 Introduction: The incidence of anal cancer is influenced by individual factors and socially determined conditions of vulnerability. In Brazil, it has increased in recent decades.
William Pereira Santos, Nathália Barbosa do Espírito Santo Mendes, Alcindo Antônio Ferla   +2 more
doaj   +1 more source

A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine. [PDF]

, 2018
Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has yet to be ...
A Purkayastha, A Umar, AA Wright, Alizee Lebeau, Aurelie Poncin, Benjamin Koopmansch, BJ Kocjan, C Martel de, C Mund, Charles M Quick, Christiane Mougin, Christopher P Crum, CS Karapetis, D Leonard, D Meulendijks, David Guenat, Diane Bruyere, DJ Jonker, DK Chan, E Serup-Hansen, EC Pirog, EJ Yang, Elodie Hendrick, F Coppede, Franck Monnien, Frederic Lambert, GJ Chang, H Wang, J Berlin, J Couzin-Frankel, J Mirkovic, JB Carpenter, Jean-Luc Prétet, JM Xu, Karin Segers, Laurence de Leval, Lucine Vuitton, M Basik, M Durst, M Ferrer Marquez, M Herfs, M Herfs, M Herfs, M Herfs, M Herfs, M Lisovsky, M Matsunaga, M Papagikos, M Yamauchi, ME Abel, Michael Herfs, Nathalie Piazzon, O Buhard, O Buhard, Olivier Peulen, P Hubert, Pascale Hubert, Patrick Roncarati, Philippe Delvenne, RD James, S Anwar, S Nagao, S Rajendra, S Valmary-Degano, SE Matlung, Severine Valmary-Degano, T Goto, T Sakamoto, V Heinemann, V Karantza, Vincent Bours, William Penny, Y Belkacemi   +72 more
core   +1 more source

Anorectal Malignant Melanoma Post- Hemorrhoidectomy

Acta Médica Portuguesa
Anorectal malignant melanoma, a rare and aggressive tumor, lacks specific symptoms and frequently presents diagnostic challenges due to its similarity to benign anorectal conditions.
Ramazan Kozan, Ozkan Akpinar, Meral Toker   +2 more
doaj   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Delayed diagnosis of Townes‑Brocks syndrome with multicystic kidneys and renal failure caused by a novel SALL1 nonsense mutation: A case report [PDF]

, 2016
Townes‑Brocks syndrome (TBS) is a rare autosomal dominant congenital anomaly syndrome characterized by the triad of anorectal, hand and external ear malformations. Kidney involvement is less common and may progress to end‑stage renal failure (ESRF) early
Bian, F, Gale, D, Jiang, GR, Lin, FJ, Lu, W, Yao, Y, Zou, R   +6 more
core   +1 more source

A importância da anuscopia de alta resolução para o diagnóstico do papilomavírus humano anorretal na forma subclínica, das lesões anais intraepiteliais e do carcinoma "in situ"anal

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: A doença causada pelo Papilomavírus Humano (HPV) tem alta incidência na população e é considerada pré-neoplásica. O objetivo deste trabalho é estudar um método que detecte o HPV anorretal na sua forma subclínica e suas alterações neoplásicas, a
João Carlos Magi, Marcos Ricardo da Silva Rodrigues, Wladimyr Dias Moreno, João Baptista de Paula Fraga, Anderson da Costa Lino Costa, Galdino José Sitônio Formiga   +5 more
doaj   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

The excess burden of cancer in men in the UK [PDF]

, 2009
In general men are at significantly greater risk than women from nearly all of the common cancers that occur in both sexes (with the exception of breast cancer) (White 2009, Wilkins 2006, DH 2007).
FORMAN, D, THOMPSON, C, WHITE, A
core  

Circulating vascular endothelial growth factor and cancer risk: A bidirectional mendelian randomization

Frontiers in Genetics, 2022
In observational studies, circulating vascular endothelial growth factor (VEGF) has been reported to be associated with certain types of cancer. The purpose of this study was to verify whether there is a causal relationship between circulating VEGF and ...
Hong Wu, Tianjun Ma, Dongli Li, Mei He, Hui Wang, Ying Cui   +5 more
doaj   +1 more source