Results 41 to 50 of about 21,652 (281)
Delayed diagnosis of Townes‑Brocks syndrome with multicystic kidneys and renal failure caused by a novel SALL1 nonsense mutation: A case report [PDF]
, 2016 Townes‑Brocks syndrome (TBS) is a rare autosomal dominant congenital anomaly syndrome characterized by the triad of anorectal, hand and external ear malformations. Kidney involvement is less common and may progress to end‑stage renal failure (ESRF) early
Bian, F +6 more
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A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
Advanced Science, EarlyView.A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Background Robot‐assisted rectal surgery (RAS) offers improved dexterity and visualization; however, the high cost of equipment and consumables remains a major challenge for hospital management. At our institution, we have adopted a combined approach using transanal total mesorectal excision (TaTME) for lower rectal cancers, aiming to shorten ...
Takeru Matsuda +9 more
wiley +1 more source
Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors [PDF]
, 2018 Background. Neuroendocrine tumors (NETs) are characterized by having behavior and prognosis that depend upon tumor histology, primary site, staging, and proliferative index.
Baldelli, Roberto +8 more
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Annals of Gastroenterological Surgery, EarlyView.This study evaluated the impact of distal resection margin (DRM) length on recurrence in 208 patients undergoing surgery for rectal neuroendocrine tumors (NETs). Our findings demonstrate that while oncological safety must unquestionably remain the top priority, a short pathological DRM (< 10 mm) does not increase recurrence risk when R0 resection is ...
Kentaro Sato +8 more
wiley +1 more source
Câncer anal e doenças sexualmente transmissíveis: qual a correlação?
Revista do Colégio Brasileiro de CirurgiõesOBJETIVO: O Câncer Anal é um tumor raro, cuja incidência é influenciada pelo comportamento sexual. O objetivo do trabalho é verificar a correlação entre o Câncer Anal e as Doenças Sexualmente Transmissíveis, como HPV, HIV, Infecção Gonocócica, Infecção ...
Leonardo de Castro Durães +1 more
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.In advanced colorectal cancer, tumors with mature tertiary lymphoid structures (TLS) exhibited abundant infiltration of CD3‐ and CD8‐positive lymphocytes in both primary and metastatic sites, indicating an activated immune response. The presence of mature TLS was also associated with favorable chemotherapy sensitivity and improved prognosis.
Nobuhiro Hosoi +9 more
wiley +1 more source
Psychosocial Challenges After Treatment for Colorectal and Anal Cancer: A Descriptive Study
Medicine AdvancesReceiving a diagnosis of cancer can profoundly impact an individual's perception of life. It can significantly affect their daily functioning because of changes in work ability, treatment‐related sequelae, and psychological distress.
Birthe Thing Oggesen, Jacob Rosenberg
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Annals of Gastroenterological Surgery, EarlyView.The present study aimed to investigate the relationship between changes in body weight and composition during chemoradiotherapy, such as the psoas muscle mass index, visceral fat index, and subcutaneous fat index obtained from computed tomography images, and long‐term outcomes in rectal cancer patients.
Shinya Abe +9 more
wiley +1 more source
A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine. [PDF]
, 2018 Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has yet to be ...
A Purkayastha +72 more
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