Results 141 to 150 of about 2,352,773 (321)

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

open access: yesAdvanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang   +13 more
wiley   +1 more source

Graphical models for marked point processes based on local independence

open access: yes, 2007
A new class of graphical models capturing the dependence structure of events that occur in time is proposed. The graphs represent so-called local independences, meaning that the intensities of certain types of events are independent of some (but not ...
Aalen   +41 more
core   +5 more sources

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

open access: yesAdvanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang   +17 more
wiley   +1 more source

Maternal separation induces long-term oxidative stress alterations and increases anxiety-like behavior of male Balb/cJ mice

open access: yesExperimental Brain Research, 2020
L. M. Malcon   +8 more
semanticscholar   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

open access: yesAdvanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang   +5 more
wiley   +1 more source

Microglial Membranes Wrapped Ultrasmall Medium‐Entropy Ru Single‐Atom Nanozyme: Enhanced Catalysis for Accelerating Inflammation/Redox Microenvironment Regulation in Intracerebral Hemorrhage

open access: yesAdvanced Science, EarlyView.
PtRhIr/Ru SAN@M nanozymes cross the blood–brain barrier and selectively accumulate in hemorrhagic brain regions. By mimicking multiple enzyme activities, they attenuate oxidative stress, modulate microglial polarization toward an anti‐inflammatory phenotype, inhibit ferroptosis, and promote neuronal repair.
Jiebo Li   +17 more
wiley   +1 more source

The effectiveness of Modular Cognitive-Behavioral Therapy (MCBT) on reducing the symptoms of separation anxiety in 6 and 7 year old children

open access: yesروانشناسی بالینی و شخصیت, 2016
Introduction: Separation Anxiety in children is a disorder that has a negative impact on social adjustment and peer relations which predicting psychiatric disorders in adolescence. If separation anxiety is not treated in childhood, the person will face a
Zohreh Abbasi   +2 more
doaj  

Associations between left-behind children’s characteristics and psychological symptoms: a cross-sectional study from China

open access: yesBMC Psychiatry
Background Parent-child separation poses a significant challenge for left-behind children (LBC). However, limited empirical evidence exists regarding the correlation between left-behind characteristics and the psychological symptoms of LBC.
Cong Liu   +6 more
doaj   +1 more source

Infant Day Care and the Working Mother: A Proposal for Reducing Maternal Anxiety [PDF]

open access: yes, 1969
My interest in the day care of children of working mothers was stimulated by my recent involvement in a study of the need for day care facilities in Kitchener-Waterloo.
Adams, David W.
core   +1 more source

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