Results 111 to 120 of about 1,049,911 (342)

Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 192, Issue 1-2, Page 3-12, January-March 2023., 2023
Abstract Ubiquitous associations have been detected between different types of childhood psychopathology and polygenic risk scores based on adult psychiatric disorders and related adult outcomes, indicating that genetic factors partly explain the association between childhood psychopathology and adult outcomes. However, these analyses in general do not
Wonuola A. Akingbuwa   +12 more
wiley   +1 more source

Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts

open access: yesAdvanced Science, EarlyView.
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang   +11 more
wiley   +1 more source

Ultrasound‐Assisted H2 Transmitter Enables Hydrogen‐Gene Therapy to Prevent Anesthesia/Surgery‐Induced Cognitive Impairment

open access: yesAdvanced Science, EarlyView.
Postoperative cognitive dysfunction (POCD) remains a challenge with no effective treatments. This study introduces a novel hydrogen‐gene therapy strategy, combining focused ultrasound and siRNA delivery via hydrogen emitters, to repair neuroinflammation in a precise and controlled manner.
Ruonan Zhan   +11 more
wiley   +1 more source

Measuring Anxiety Levels with Head Motion Patterns in Severe Depression Population [PDF]

open access: yesarXiv
Depression and anxiety are prevalent mental health disorders that frequently cooccur, with anxiety significantly influencing both the manifestation and treatment of depression. An accurate assessment of anxiety levels in individuals with depression is crucial to develop effective and personalized treatment plans.
arxiv  

Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3‐Deficient Rats

open access: yesAdvanced Science, EarlyView.
This study examines the effects of Shank3 mutation on the mesoaccumbens pathway using a Shank3‐deficient rat model. The findings reveal altered social reward processing in these rats, accompanied by changes in dopaminergic and GABAergic neural activity within the ventral tegmental area (VTA) and dopamine release in the nucleus accumbense (NAc ...
Marie Barbier   +4 more
wiley   +1 more source

Detecting a Proxy for Potential Comorbid ADHD in People Reporting Anxiety Symptoms from Social Media Data [PDF]

open access: yesProceedings of the 9th Workshop on Computational Linguistics and Clinical Psychology (CLPsych 2024)
We present a novel task that can elucidate the connection between anxiety and ADHD; use Transformers to make progress toward solving a task that is not solvable by keyword-based classifiers; and discuss a method for visualization of our classifier illuminating the connection between anxiety and ADHD presentations.
arxiv  

EFFECTS OF ANXIETY AND MORPHINE ON DISCRIMINATION OF INTENSITIES OF PAINFUL STIMULI [PDF]

open access: bronze, 1952
Harris E. Hill   +3 more
openalex   +1 more source

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