Results 131 to 140 of about 1,037,362 (313)

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

open access: yesAdvanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong   +11 more
wiley   +1 more source

Efficacy of combined treatment based on acceptance and commitment in treatment of women with generalized anxiety disorder

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2017
Background and Objective: General anxiety disorder is one of the chronic disorders in the general population and population with clinical symptoms. This study was conducted to evaluate the efficacy of combined treatment based on acceptance and commitment
Majid Mahmoud Alilou   +2 more
doaj  

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

open access: yesAdvanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li   +13 more
wiley   +1 more source

Neuroenhancement of Exposure Therapy in Anxiety Disorders

open access: gold, 2015
Stefan G. Hofmann   +2 more
openalex   +1 more source

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li   +11 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei   +4 more
wiley   +1 more source

Perceived Parenting Styles of Patients with Generalized Anxiety Disorder

open access: yesJournal of Health Science and Medical Research (JHSMR), 2015
In psychiatry, generalized anxiety disorder is a chronic and common disorder. The etiologies of generalized anxiety disorder can be divided into biological factors (neurotransmitter abnormality) and psychological factors or parenting style.
Aimorn Jiraphan, Jarurin Pitanupong
doaj  

What is the effect of homework engagement in group cognitive behavioral therapy for anxiety disorders and depression? [PDF]

open access: gold
Oliver Rumle Hovmand   +9 more
openalex   +1 more source

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